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Macromol, Volume 6, Issue 4

2026 December - 28 articles

Cover Story: Traditionally regarded as a structural component of the extracellular matrix, hyaluronan is emerging as an active regulator of tissue biology. This review explores how ultra-high-molecular-weight hyaluronan (UHMW-HA), through its exceptional chain length, hydration, and viscoelastic properties, can organize the pericellular matrix and influence cell signaling, immune homeostasis, and responses to injury and aging. Drawing on evidence from the naked mole-rat and advances in biomaterials engineering, we introduce UHMW-HA as a “living hydrogel” and discuss its potential to inspire adaptive regenerative materials for tissue repair and healthy aging. View this paper
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Articles (28)

  • Article
  • Open Access

10 November 2026

Taro (Colocasia esculenta L. Schott) starch is a promising biopolymer for film applications; however, the effects of extraction protocols on the composition and functionality of recovered starch-rich fractions and the properties of starch-based films...

  • Article
  • Open Access
34 Views
15 Pages

Effect of Initiator Concentration on the Bulk Free-Radical Copolymerization of N-Vinylcaprolactam and N-Vinylimidazole

  • Alesya V. Vorozheykina,
  • Ekaterina D. Denisova,
  • Mikhail M. Il’in,
  • Mikhail K. Glagolev and ,
  • Pavel V. Komarov,
  • Alexander S. Peregudov,
  • Anna I. Barabanova and
  • Alexey R. Khokhlov
  • + 3 authors+ 0 author

6 November 2026

The bulk radical copolymerization of N-vinylcaprolactam (VCL) and N-vinylimidazole (VI) initiated by 2,2′-azobisisobutyronitrile (AIBN) was investigated. The composition of the resulting amphiphilic copolymers is always enriched in VI units and...

  • Article
  • Open Access
122 Views
24 Pages

Relationships Between Composition, Microstructure, Rheology, and Functional Performance in Carbopol-Based Emulgels and Bigels

  • Sonya Tsibranska-Gyoreva,
  • Petya Peneva,
  • Yana Gvozdeva,
  • Nadya Politova-Brinkova and ,
  • Margarita Kassarova and
  • Slavka Tcholakova
  • + 1 author+ 0 author

31 October 2026

This study investigates composition-microstructure-rheology-performance relationships in Carbopol-based emulgels and bigels containing different oils. Optical microscopy revealed polydisperse droplets in liquid paraffin, isopropyl myristate, and almo...

  • Article
  • Open Access
111 Views
19 Pages

Ficin-Modified Chitosan Hydrogels: In Vitro Hemocompatibility and Hemostatic Performance

  • Maria S. Lavlinskaya,
  • Andrey V. Sorokin,
  • Yulia A. Redko,
  • Anastasia N. Dubovitskaya and ,
  • Victoria A. Koroleva,
  • Svetlana S. Goncharova,
  • Svetlana M. Pankova,
  • Elena V. Belousova,
  • Marina G. Holyavka and
  • Valeriy G. Artyukhov
  • + 5 authors+ 0 author

30 October 2026

Bleeding remains a leading cause of death in trauma and surgery, which drives the search for effective local hemostatic materials. Chitosan is a promising candidate because of its biocompatibility, biodegradability, and intrinsic hemostatic activity,...

(This article belongs to the Special Issue Recent Trends in Carbohydrate-Based Therapeutics)
  • Review
  • Open Access
134 Views
33 Pages

Aquaculture Wastewater as a Feedstock for Functional Seaweed Polysaccharides: Linking Nutrient Recovery, Macromolecular Architecture and Agricultural Valorization

  • Maria Nancy Herrera-Moreno,
  • Prabhaharan Renganathan,
  • Edgar Omar Rueda-Puente,
  • Luis Daniel García-Rodríguez and ,
  • Magnolia Montoya-Mejía and
  • Juan Carlos Sainz-Hernandez
  • + 1 author+ 0 author

29 October 2026

Aquaculture wastewater supplies nutrients for seaweed cultivation, but its suitability for producing functional polysaccharides remains uncertain. This critical review examines the evidence connecting wastewater composition, nutrient assimilation, po...

  • Perspective
  • Open Access
226 Views
28 Pages

28 October 2026

The field of polymer upcycling through depolymerization is rapidly advancing, offering innovative strategies to convert waste plastics into valuable small molecules, specialty chemicals, and new polymers. This Perspective highlights key depolymerizat...

  • Article
  • Open Access
164 Views
27 Pages

Active Chitosan/Gelatin Composite Films Incorporated with Biosynthesized AgNP-Loaded Nanoliposomes: Characteristics, Bioactivities, Release Rate and Application for Shelf-Life Extension of Mussel Meat

  • Varsha Likhar,
  • Krisana Nilsuwan,
  • Thummanoon Prodpran,
  • Yu Fu and ,
  • Tao Yin,
  • Yadong Zhao,
  • Bin Zhang and
  • Soottawat Benjakul
  • + 3 authors+ 0 author

27 October 2026

Functional biopolymer-based packaging systems incorporating nanostructured active components have gained increasing attention for improving food stability and extending shelf-life. Chitosan/gelatin (CS/GE) composite films containing biosynthesized si...

  • Article
  • Open Access
240 Views
27 Pages

Encapsulation of Equisetum hyemale Extract in Immunomodulatory Collagen–Polyurethane–Dextran Semi-Interpenetrating Network Hydrogels Attenuates Cytotoxicity and Accelerates Diabetic Wound Healing

  • Hilda Aguayo-Morales,
  • Jesús A. Claudio-Rizo,
  • Crystel A. Sierra-Rivera,
  • Sonia Y. Silva-Belmares and ,
  • Adán Herrera-Guerrero,
  • Álvaro Jovanny Tovar-Cuevas and
  • Luis E. Cobos-Puc
  • + 2 authors+ 0 author

22 October 2026

Equisetum hyemale extract promotes wound healing in diabetic rats, but its cytotoxicity limits its use. This study aimed to encapsulate the extract in collagen–polyurethane–dextran semi-interpenetrating network hydrogels containing 20&nda...

  • Review
  • Open Access
302 Views
69 Pages

19 October 2026

Biomacromolecules have emerged as versatile building blocks for advanced drug delivery systems owing to their biocompatibility, biodegradability, chemical functionality, molecular recognition, and capacity for hierarchical organization. However, thei...

  • Article
  • Open Access
447 Views
20 Pages

Impact of Ethanol Precipitation Gradient on the Molecular Weight Fractionation and Rheological Behavior of Ganoderma lucidum Polysaccharides

  • Maurício Kodgi Ivano Filho,
  • Hellen Abreu,
  • Ana Carolina Vaz de Almeida,
  • Alex Leandro dos Santos de Sá and ,
  • Dib Mady Diniz Gomes,
  • Lucimara M. C. Cordeiro,
  • Fernanda Fogagnoli Simas and
  • Fhernanda Ribeiro Smiderle
  • + 3 authors+ 0 author

13 October 2026

This study investigated the impact of a sequential ethanol precipitation gradient on the molecular weight distribution, chemical composition, and macromolecular architecture of Ganoderma lucidum polysaccharides. Fractions obtained via serial precipit...

  • Review
  • Open Access
250 Views
27 Pages

13 October 2026

Hyaluronan (HA) has traditionally been viewed as a structural component of the extracellular matrix, valued primarily for its viscoelastic, lubricating, and hydrating properties. However, accumulating evidence suggests that ultra-high-molecular-weigh...

(This article belongs to the Special Issue Recent Trends in Carbohydrate-Based Therapeutics)
  • Review
  • Open Access
221 Views
29 Pages

10 October 2026

Many studies have been carried out on pure polylactic acid (PLA) material to provide good roadmaps to additively manufacture this material when using Fused Filament Fabrication (FFF), which is considered one of the most used additive manufacturing (A...

(This article belongs to the Topic Recent Advances in Composite Biomaterials)
  • Review
  • Open Access
271 Views
49 Pages

Amino Acid-Derived Carbon Dots Exhibiting Chiroptical Properties: Recent Advances and Structure–Property Relationships

  • Eleonora Sofia Cama,
  • Benedetta Maria Squeo,
  • Francesco Galeotti,
  • Umberto Giovanella and
  • Mariacecilia Pasini

10 October 2026

Amino acid-derived chiral carbon dots (c-CDs) combine the optical properties of CDs with molecular chirality, offering broad potential in sensing, catalysis, biomedicine, and photonic technologies. This review summarizes recent advances in c-CDs prep...

  • Article
  • Open Access
224 Views
27 Pages

8 October 2026

In recent years, bioplastics have been developed as a biodegradable alternative to conventional plastics. Commonly used for single-use packaging, it is expected that bioplastics will follow a similar trajectory and enter the aquatic environment, yet...

  • Article
  • Open Access
419 Views
14 Pages

Spray-Dried Whey Protein Microcapsules for the Stabilization of Mexican Firecracker (Hamelia patens)-Derived Phytochemicals: Antioxidant and Antimicrobial Efficacy

  • María del Carmen Gutiérrez-Sánchez,
  • Mariela R. Michel,
  • Antonio Julián-Flores,
  • Mayra Aguilar-Zárate and ,
  • Romeo Rojas,
  • Guillermo Cristian G. Martínez-Ávila,
  • María Luisa Carrillo-Inungaray and
  • Pedro Aguilar-Zárate
  • + 3 authors+ 0 author

4 October 2026

This study evaluated spray-dried microcapsules as a strategy for preserving the antioxidant and antimicrobial activities of purified phytochemicals from Hamelia patens. Maltodextrin, whey protein, and pectin were screened as wall materials, and whey...

  • Article
  • Open Access
216 Views
18 Pages

3 October 2026

Spatholobi caulis is considered an important medicinal plant in traditional Chinese medicine, which has the functions of promoting blood circulation, replenishing blood, enhancing immunity, and stimulating hematopoiesis, but its bioactive polysacchar...

(This article belongs to the Special Issue Recent Trends in Carbohydrate-Based Therapeutics)
  • Article
  • Open Access
336 Views
25 Pages

Amino-Functionalized Cobalt Ferrite/PLA Nanocomposites for FDM-Printed Magnetic Scaffolds

  • Danyelle Garcia Guedes,
  • José Adeilton de Carvalho Filho,
  • Abner Pinheiro Carvalho,
  • Helder de Lucena Pereira and ,
  • Meirilany Rozeno Costa,
  • Adriano Lima da Silva,
  • Edcleide Maria Araújo,
  • Ana Cristina Figueiredo de Melo Costa and
  • Carlos Bruno Barreto Luna
  • + 4 authors+ 0 author

3 October 2026

Incorporating magnetic nanoparticles into poly(lactic acid) (PLA) for fused deposition modeling (FDM) poses a processability challenge: poor nanoparticle–matrix interfacial compatibility disrupts melt homogeneity. Cobalt ferrite nanoparticles (...

(This article belongs to the Topic Advances in Sustainable Composite Materials)
  • Review
  • Open Access
237 Views
36 Pages

3 October 2026

Marine collagen peptides have emerged as promising natural cryoprotective agents due to their ability to regulate ice crystal growth and reduce freeze-induced quality deterioration in frozen foods. This review examines the current understanding of co...

  • Article
  • Open Access
279 Views
16 Pages

Gelatin–Curcumin Nanoparticles Produced by Uniaxial Electrospraying: Rheological Behavior of Precursor Gelatin Solutions and Physicochemical Characterization of Nanoparticles

  • Ana Victoria Tapia-Gastélum,
  • Carlos Gregorio Barreras-Urbina,
  • José Agustín Tapia-Hernández,
  • Francisco Rodríguez-Félix and ,
  • Tomás Jesús Madera-Santana,
  • Lorena Armenta-Villegas,
  • Abril Zoraida Graciano-Verdugo,
  • Itzel Yanira López-Peña,
  • Betzabe Ebenhezer López-Corona and
  • Idania Emedith Quintero-Reyes
  • + 6 authors+ 1 author

3 October 2026

Electrospraying has emerged as a promising technique for producing biopolymeric structures containing bioactive compounds. In this study, gelatin and gelatin–curcumin nanoparticles were produced by uniaxial electrospraying, and the effects of g...

  • Article
  • Open Access
326 Views
12 Pages

Effect of Ultrasound on the Physicochemical and Microbiological Performance Characteristics of Ampicillin-Loaded Chitosan-Phytic Acid Nanoparticles

  • Luis Carlos Durango-Urbano,
  • Sharon Jiney Valencia-Ojeda,
  • Constain H. Salamanca,
  • John Rojas and ,
  • José Oñate-Garzón and
  • Yhors Ciro
  • + 1 author+ 0 author

3 October 2026

The increasing prevalence of antimicrobial resistance has driven the development of nanocarrier-based antibiotic delivery systems. In this study, ampicillin-loaded chitosan nanoparticles crosslinked with phytic acid were synthesized by ultrasound-ass...

(This article belongs to the Special Issue Chitosan-Based Materials for Biomedical Applications: Derivatives and Composites)
  • Review
  • Open Access
311 Views
38 Pages

2 October 2026

Peptide and oligonucleotide therapeutics are dependent on sequence-defining chemical synthesis, but product complexity additionally arises from structural modifications, formulation and delivery. In this context, their quality cannot be assessed only...

  • Review
  • Open Access
264 Views
21 Pages

2 October 2026

Pineapple crown waste is a cellulose-rich residue generated along fresh-fruit and processing chains and is increasingly investigated as a feedstock for higher-value cellulosic materials. This review critically examines conversion of pineapple crown a...

(This article belongs to the Special Issue Advances in Starch and Lignocellulosic-Based Materials)
  • Review
  • Open Access
982 Views
52 Pages

Engineering Next-Generation Taxane Nanomedicines for Clinical Translation

  • Diksha Nagpal,
  • Shakti Nagpal,
  • Himanshu Kathuria,
  • Murali Monohar Pandey and ,
  • Vineet Mittal and
  • Deepak Kaushik
  • + 1 author+ 0 author

30 September 2026

Background: Taxanes have been a cornerstone in the management of a wide range of cancers, including ovarian, breast, and lung cancer, owing to their microtubule-stabilizing mechanism. Despite their clinical success, their therapeutic utility remains...

  • Article
  • Open Access
406 Views
37 Pages

Cassava Starch–Beeswax Edible Coatings Enriched with Pomegranate Peel Extract Improve the Microbiological Stability and Quality of Coalho Cheese

  • Bárbara Camila Firmino Freire,
  • Renata Cristina Borges da Silva Macedo,
  • Nícolas Oliveira de Araújo,
  • Bárbara Jéssica Pinto Costa and ,
  • Tallyson Nogueira Barbosa,
  • Flamênia Shirley Ribeiro Silva,
  • Heithor Syro Anacleto de Almeida,
  • José Lucas Girão Rabelo,
  • Gabrielle Cavalcante Barbosa Lopes and
  • Karoline Mikaelle de Paiva Soares
  • + 13 authors+ 8 authors

30 September 2026

Coalho cheese is a highly consumed fresh dairy product in northeastern Brazil; however, its high moisture content and susceptibility to microbial contamination limit shelf life and compromise product safety. In this context, active edible coatings ha...

(This article belongs to the Special Issue Advances in Starch and Lignocellulosic-Based Materials)
  • Communication
  • Open Access
268 Views
10 Pages

28 September 2026

Diabetes mellitus affects nearly half a billion people worldwide and is primarily caused by the loss of insulin-producing cells, which are essential for maintaining normal blood glucose levels. In this study, we optimized a CRISPR activation (CRISPRa...

(This article belongs to the Special Issue Chitosan-Based Materials for Biomedical Applications: Derivatives and Composites)
  • Article
  • Open Access
330 Views
20 Pages

Interfacial Structuring and Functional Enhancement in Pectin-Sodium Caseinate Films Loaded with Deverra tortuosa Essential Oil Nanoemulsions

  • Tahani Zorgui,
  • Denis Rodrigue,
  • Emilie Dumas,
  • Géraldine Agusti and ,
  • Mehrez Romdhane and
  • Adem Gharsallaoui
  • + 1 author+ 0 author

25 September 2026

This study aimed to develop bioactive pectin-based films incorporating Deverra tortuosa (D. tortuosa) essential oil (EO) nanoemulsions stabilized by sodium caseinate for potential active food packaging applications. EO nanoemulsions were incorporated...

  • Article
  • Open Access
299 Views
24 Pages

Ultrasound-Assisted Formation and Investigation of Sodium Alginate-Stabilized Clove Essential Oil Nanoemulsions with Enhanced Antimicrobial Activity

  • Malek Toumi,
  • Faten Debbabi,
  • Neji Ladhari,
  • Mohamed Ali Lassoued and ,
  • Ibrahim Jlassi and
  • Maha Mastouri
  • + 1 author+ 0 author

25 September 2026

Ultrasound-assisted emulsification is an effective approach for producing stable nanoemulsions containing bioactive essential oils. In this study, sodium alginate-stabilized clove essential oil (CEO) nanoemulsions were prepared by varying the ultraso...

  • Article
  • Open Access
339 Views
22 Pages

24 September 2026

Gold nanoparticles (AuNPs) are versatile nanomaterial scaffolds for imaging and multifunctional platform development; however, biologically addressable multicomponent coatings often require multistep chemistry that can limit accessibility and reprodu...

(This article belongs to the Topic Future Trends in Polymer Science: Materials, Design, and Advanced Applications)
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Macromol - ISSN 2673-6209