2026 December - 68 articles
Background and Clinical Significance: Gynecomastia is not considered as an expected adverse event in patients treated by asciminib. We provide the first detailed description of this occurrence. Case presentation: Two elderly patients treated with asc...
Background/Objectives: Bullous pemphigoid (BP) in children is a rare autoimmune subepidermal blistering condition that shows significant clinical variability depending on age. This narrative review summarizes the available literature on the epidemiol...
Background/Objectives: Feedforward—viewing a self-representation performing at a level not yet achieved—is increasingly delivered through virtual reality, avatars and generative artificial intelligence. This critical review synthesizes th...
Background and Clinical Significance: Listeria monocytogenes meningitis is an uncommon cause of bacterial meningitis, with a mortality rate close to 15%, particularly in immunocompromised patients. A concurrent presentation with neuropsychiatric...
Objectives: To critically evaluate the clinical evidence on patient-, tooth-, biology-, and treatment-related risk factors for endodontic flare-ups and postoperative pain after nonsurgical root canal therapy. Particular emphasis was placed on the iss...
Background and Clinical Significance: Adult T-cell leukemia/lymphoma (ATLL) is an aggressive mature T-cell malignancy associated with human T-lymphotropic virus type 1 (HTLV-1) and generally has poor outcomes in its acute form. Case Presentation: A 3...
Background and Clinical Significance: Popliteal artery aneurysmal involvement is an uncommon arterial manifestation of Behçet disease, and bilateral disease with thrombotic complications is particularly rare. Management is challenging because...
Background/Objectives: The superior gluteal artery (SGA) is usually the largest branch of the internal iliac artery. It lies close to the ventral rami of the sacral plexus and to the internal iliac vein (IIV). The purpose of the present study was to...
Background and Clinical Significance: Sarcoidosis and lymphoma may precede, follow or accompany each other, and lymphoma can also induce a sarcoid-like granulomatous reaction. Case Presentation: We describe a 62-year-old woman with exertional dyspnea...
Skin disorders are one of the commonest causes of children’s referral to the emergency department and include changes in skin structure and appearance due to allergic reaction, infection, trauma or systemic disease. Skin infection can also be a...
Background and Clinical Significance: B-vitamin deficiencies can lead to widespread diseases including cardiac, neurologic, hematologic, dermatologic, and oral pathologies. The often-multi-organ effects of B-vitamin deficiencies occur secondary to th...
Blunt cardiac trauma is rare but potentially fatal, especially when associated with cardiac chamber rupture. We report a case of a 53-year-old female who sustained right atrial rupture and pericardial tear following a motor vehicle collision. The pat...
Background and Clinical Significance: Autoimmune gastritis (AIG) can cause iron-deficiency anemia (IDA) before vitamin B12 deficiency develops. Although AIG-associated IDA is more common in younger individuals, it can also occur in older adults. Type...
Background and Clinical Significance: CNGA3 variants have been implicated in congenital retinal photoreceptor disorders, especially those affecting cone photoreceptor cells and therefore color discrimination. This report details the diagnosis an...
Background and Clinical Significance: Pulmonary cement embolism (PCE) is a recognized complication of vertebral augmentation, with presentations ranging from incidental radiological findings to severe cardiopulmonary compromise. This case series illu...
Background and Clinical Significance: Azacitidine (AZA) is a hypomethylating agent used in the treatment of several hematologic malignancies. Although its hematologic and gastrointestinal toxicities are well described, cardiovascular adverse events r...
Background: Within gynecological oncology, vulvar metastases represent an exceptionally rare clinical entity, accounting for 5% to 8% of all observed vulvar lesions. Secondary vulvar tumors usually reflect advanced metastatic disease and are associat...
Background and Clinical Significance: Acute generalized exanthematous pustulosis (AGEP) is a rare, usually drug-induced severe cutaneous reaction characterized by the sudden appearance of numerous sterile non-follicular pustules on erythematous skin....
Background and Clinical Significance: Seminal vesicle abscess (SVA) is a rare genitourinary condition with a nonspecific presentation that may delay diagnosis. Treatment includes antimicrobial therapy and, when necessary, drainage. Managing large col...
Urinary bladder catheterization in swine can be technically challenging, particularly when experimental preparation also requires femoral vascular access. We illustrate a preperitoneal approach combining femoral vessel catheterization and cystostomy...
Oral and maxillofacial diseases include a variety of developmental abnormalities, inflammatory and immune-mediated conditions, salivary gland disorders, periodontal diseases, benign and malignant tumors, and complications related to dental treatment...
Background: Effective management of peri-implant disease relies primarily on mechanical removal of the bacterial biofilm. However, achieving adequate surface decontamination can be challenging due to complex implant-surface morphology and restricted...
Background: Chikungunya virus (CHIKV) has circulated in the Philippines for more than six decades. We systematically reviewed the epidemiology of CHIKV in the Philippines, integrating evidence on transmission, seroprevalence, diagnostics and molecula...
Background and Clinical Significance: Uterine artery embolization (UAE) is a well-established treatment for symptomatic leiomyomas; however, treatment failure may occur owing to collateral arterial supply from extra-uterine sources. While ovarian art...
Background and Clinical Significance: Herpes zoster (HZ) results from reactivation of latent varicella-zoster virus and disproportionately affects older adults. Antiviral therapy and systemic analgesia are well established, but local wound care of th...
Background and Clinical Significance: Posterior epidural migration of a sequestered disc fragment is a very rare entity that may present significant diagnostic challenges, due to radiological characteristics that may mimic other lesions; Case Present...
Background/Objectives: Chronic constipation in patients with autism spectrum disorder (ASD) may be undetected during routine care and can exacerbate ASD symptoms such as irritability and hyperactivity. This retrospective study evaluated the prevalenc...
Background and Clinical Significance: Tricuspid transcatheter edge-to-edge repair (T-TEER) is an established therapy for severe tricuspid regurgitation (TR) in selected patients. Single-leaflet device attachment (SLDA) is the commonest device-related...
Background and Clinical Significance: Epiretinal membranes (ERMs) are uncommon in young patients, and spontaneous anatomical resolution is rare. We report spontaneous disappearance of a unilateral ERM after marked worsening in an 18-year-old woman wi...
Background and Clinical Significance: Inflammatory linear verrucous epidermal nevus (ILVEN) is a non-melanocytic skin lesion, typically present in early childhood, that is characterized by a linear verrucous appearance distributed along Blaschko&rsqu...
Background and Clinical Significance: The nutritional management of onco-geriatric patients after a total gastrectomy remains a challenge, especially in the context of postoperative complications, such as stenosis of the esophagojejunal anastomosis,...
Background and Clinical Significance: Kawasaki disease (KD) lacks specific diagnostic tests and requires early diagnosis and treatment to prevent coronary artery lesions. Concurrent infections may produce KD-like presentations; however, practical man...
Background and Clinical Significance: Removable partial dentures still present a relevant treatment option in an aging population. With the exception of clasps, the vast majority of attachment systems available for anchoring these restorations on nat...
Background and Clinical Significance: Thoracic endovascular aortic repair (TEVAR) involving zone 2 of the aortic arch frequently necessitates left subclavian artery (LSA) revascularization to reduce the risk of neurologic and ischemic complications....
Background and Clinical Significance: Longstanding human immunodeficiency virus (HIV) may remain clinically unrecognized until adolescence. Growth failure, delayed puberty, and recurrent or atypical infections may represent manifestations of underlyi...
Background and Clinical Significance: Refractory below-knee amputation (BKA) stump wounds can delay prosthetic rehabilitation. This report describes wound healing during multimodal care that included autologous platelet-rich plasma (PRP) activated wi...
Background and Clinical Significance: Bow Hunter’s syndrome is an uncommon cause of vertebrobasilar insufficiency caused by dynamic vertebral artery narrowing during head rotation or extension. It is classically described at the atlantoaxial le...
Background and Clinical Significance: Cryptococcal meningitis remains a life-threatening complication of advanced HIV infection. Its recognition can be challenging when neurological manifestations are nonspecific or cerebrospinal fluid inflammation i...
Background/Objectives: World Health Organization (WHO) Grade 2–3 meningiomas have high recurrence rates despite postoperative radiotherapy. This study aimed to characterize patterns of failure and clinical outcomes after postoperative external...
Background and Clinical Significance: Frontal sinus disease remains one of the most challenging conditions in rhinology due to its complex and variable anatomy and high tendency toward postoperative stenosis. Paranasal sinus mucoceles are uncommon, d...
Background and Clinical Significance: Thyroid metastasis from clear cell renal cell carcinoma (ccRCC) is uncommon and may occur after radical nephrectomy despite no evidence of residual or metastatic disease at that time. Diagnosis can be challenging...
Background and Clinical Significance: Meckel’s diverticulum is a remnant of the omphalomesenteric duct, arising from an incomplete obliteration of the embryonic vitelline duct, which connects the fetal gut to the yolk sac, typically regressing...
Background and Clinical Significance: Longitudinal observations that combine major postoperative weight loss with limb-specific gait assessment after total knee arthroplasty (TKA) are uncommon. This case report describes three single-trial instrument...
Background and Clinical Significance: Tympanostomy tubes (TTs) are normally extruded into the external auditory canal within 6–18 months, whereas medial migration into the middle ear is a rare complication. Medialized tubes have been associated...
Background and Clinical Significance: Before effective viral inactivation of plasma-derived factor concentrates, many patients with hemophilia acquired hepatitis C virus infection and later developed cirrhosis or hepatocellular carcinoma. Liver trans...
A 69-year-old man with a history of heavy alcohol consumption and poor nutrition presented with disorientation and gait instability. The cognitive assessment was severely affected, with the Hasegawa Dementia Scale-Revised score was 4. Neurological ex...
Background and Clinical Significance: Hemorrhage from advanced oral cancer can threaten both circulation and airway patency. Case Presentation: A 60-year-old man with advanced left buccal mucosal squamous cell carcinoma (cT4bN2bM0, Stage IVB) was med...
Background and Clinical Significance: Idiopathic megacolon (IM) in adults is a rare disease with an unknown aetiology. The condition remains poorly understood, with ongoing debate over the specificity of its histopathology. Case Presentation: Case 1:...
Background and Clinical Significance: Multivessel coronary artery spasm (CAS) is an uncommon, high-risk form of vasospastic angina that can produce transient ST-segment elevation mimicking acute myocardial infarction. Evidence to guide management whe...
Background and Clinical Significance: A 4-year-old nonverbal boy with level 3 autism spectrum disorder and Duchenne muscular dystrophy (DMD) who was receiving chronic prednisone therapy presented to the emergency room with acute appendicitis. The dia...
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