2026 September - 123 articles
Background and Clinical Significance: Older, frail patients with relapsed diffuse large B-cell lymphoma (DLBCL) face limited treatment options due to poor tolerance for standard cytotoxic chemotherapy. While novel chemotherapy-free regimens like pola...
Background and Clinical Significance: Malignant priapism is a rare manifestation of advanced malignancy caused by malignant infiltration of the corpora cavernosa. We report a case of persistent and refractory priapism associated with penile carcinoma...
Background: Oral potentially malignant disorders (OPMDs) comprise clinically and histologically heterogeneous lesions associated with an increased risk of oral squamous cell carcinoma (OSCC). Histopathological grading of oral epithelial dysplasia (OE...
Background and Clinical Significance: Intimal sarcoma is a rare, aggressive malignancy of the large arteries that grows within the vessel lumen and frequently mimics thromboembolic disease, leading to diagnostic delay. Flow restoration and tissue bio...
Background and Clinical Significance: Anticoagulation timing after atrial fibrillation (AF)-related ischemic stroke is uncertain when hemorrhagic transformation (HT) is progressive. Although early direct oral anticoagulant (DOAC) initiation is suppor...
Background and Clinical Significance: Collagenous gastritis (CG) is a rare disorder characterized by subepithelial collagen deposition, typically presenting in children with iron deficiency anemia (IDA) and abdominal pain. Its pathogenesis remains un...
Background and Clinical Significance: Lymphatic malformations (cystic lymphangiomas) are rare benign tumors in adults, with retroperitoneal and ischioanal involvement being exceptionally uncommon. These lesions often present significant surgical chal...
Background: Trauma surgeons face a challenge in the management of high-grade pancreatic injuries (HGPIs), as optimal strategies remain controversial. HGPIs are uncommon and difficult to manage due to dynamic trauma physiology and complications from t...
Background and Clinical Significance: Congenital tufting enteropathy (CTE), or autosomal recessive congenital diarrhea type 5 (DIAR5), is a rare intestinal epithelial disorder characterized by severe neonatal-onset watery diarrhea, failure to thrive,...
Background and Clinical Significance: Melanoma is predominantly a cutaneous malignancy, whereas metastatic involvement of the endometrium is exceptionally rare. Melanoma of unknown primary (MUP) accounts for a small portion of such cases. Patients ty...
Background and Clinical Significance: Epstein–Barr virus (EBV) is a common infection that rarely causes acute pancreatitis. EBV-associated acute pancreatitis is an uncommon but potentially serious complication that may result from direct viral...
Background and Clinical Significance: Cancer-associated retinopathy (CAR) is a rare paraneoplastic autoimmune retinopathy caused by antibodies targeting tumor antigens with cross-reactivity to retinal proteins. Paraneoplastic cerebellar degeneration...
Background and Clinical Significance: Hemoptysis caused by acute type B aortic dissection rupturing into the lung is rare but life-threatening; Case Presentation: An 81-year-old man receiving maintenance hemodialysis developed hemoptysis due to an ao...
Background and Clinical Significance: Congenital hyperinsulinism (CHI) is a disorder involving excessive insulin secretion due to mutations in the insulin regulation pathways. Patients are typically diagnosed during infancy following recurrent hypogl...
Background and Clinical Significance: In two-stage implant treatment the cover screw must be removed at second-stage surgery. Removal is occasionally prevented by cold welding or seizure. When the drive slot is damaged by escalating torque, no standa...
Background and Clinical Significance: Interstitial lung disease (ILD) is an uncommon but potentially serious complication of imatinib. Its histopathological characterization has so far relied on surgical biopsy or transbronchial forceps sampling, and...
Introduction and Clinical Significance: Descemet membrane detachment (DMD) is an uncommon but potentially vision-threatening complication of anterior segment surgery. Although immune-mediated graft rejection is a recognized cause of postoperative gra...
Background and Clinical Significance: Dystrophic calcinosis cutis involves calcium deposition in damaged or chronically inflamed tissues despite normal calcium and phosphate metabolism. Although typically associated with systemic sclerosis and dermat...
Background: Granular changes observed under band-limited epipharyngeal endoscopy are considered a characteristic finding of chronic epipharyngitis; however, their biological significance remains unclear. This study investigated whether granular chang...
We describe a rare case of LRV pseudo-fenestration in a 68-year-old female identified on contrast-enhanced multidetector computed tomography. Unlike true fenestration, in which a single vessel splits and reunites, this pseudo-fenestration resulted fr...
Background and Clinical Significance: Local recurrence of extremity leiomyosarcoma after multiple operations and radiotherapy presents a major therapeutic challenge. Adequate oncologic clearance must be balanced against preservation of skeletal stabi...
Background: Pemphigus is a rare group of autoimmune blistering diseases characterized by autoantibody-mediated loss of keratinocyte adhesion, resulting in intraepithelial blister formation involving the skin and mucous membranes. Pemphigus Vulgaris (...
Background: Oral cavity cancer is a clinically relevant subgroup of head and neck malignancies and is associated with substantial treatment burden and healthcare utilization. Hospital length of stay (LOS) is an important indicator of inpatient resour...
Background and Clinical Significance: Patent Blue V (PBV) is widely used for sentinel lymph node mapping but may rarely cause severe hypersensitivity reactions. These reactions can present atypically, with predominant cardiovascular collapse and mini...
Background and Clinical Significance: Adult intussusception is rare, accounting for approximately 5% of all intussusceptions and 1–5% of adult bowel obstructions, whereas the ileo–ileo–colic subtype is exceptionally uncommon. We rep...
Introduction and Clinical Significance: Skeletal dysplasias comprise a genetically heterogeneous group of disorders with substantial phenotypic overlap, often complicating diagnosis. Clinical exome sequencing (CES) can facilitate molecular diagnosis...
Background and Clinical Significance: Sodium–glucose cotransporter-2 (SGLT2) inhibitors cause persistent glucosuria, which has been hypothesized to facilitate urinary tract infection (UTI) when urinary stasis or anatomic variants coexist; causa...
Background and Clinical Significance: Heart failure with reduced ejection fraction (HFrEF) is highly prevalent among patients with end-stage kidney disease (ESKD) undergoing maintenance hemodialysis (MHD) and is associated with poor clinical outcomes...
Background and Clinical Significance: Wernicke encephalopathy (WE) is a potentially reversible neurological emergency caused by thiamine deficiency. Although classically associated with alcohol use, it may also occur after gastrointestinal surgery an...
Background and Clinical Significance: Horner’s syndrome is an uncommon but recognised complication of neuroaxial analgesia in obstetric procedures, with an incidence of 0.4–4%. Case Presentation: This case report describes a 28-year-old p...
Background and Clinical Significance: Implant impressions can present inaccuracies, affected by many factors, such as impression technique, impression material, and parallelism or lack thereof among the implants. The use of a verification index can a...
Background and Clinical Significance: Carbimazole is a widely used medication to treat Graves’ disease, although it can rarely cause acquired aplastic anemia, a complication that happens in less than 0.01% of people. Case Presentation: We repor...
Background and Clinical Significance: Meckel’s diverticulum is the most common congenital anomaly of the gastrointestinal tract and an uncommon cause of small bowel obstruction in adults, in which the diverticulum or a band arising from it typi...
Background and Clinical Significance: Pancreatic ductal adenocarcinoma (PDAC) is an aggressive malignancy with a poor prognosis, even in resectable disease. Molecular alterations in the four major driver genes (KRAS, SMAD4, CDKN2A, and TP53) have bee...
Background and Clinical Significance: People with HIV (PWH) experience an elevated risk of atherosclerotic cardiovascular disease (ASCVD), driven by chronic immune activation, metabolic toxicities of antiretroviral therapy (ART), and traditional risk...
Background and Clinical Significance: Diabetic ketoacidosis (DKA) is a common presentation of new-onset type 1 diabetes mellitus in children; however, severe DKA complicated by acute pancreatitis, dialysis-requiring acute kidney injury (AKI), severe...
Background and Clinical Significance: Facial aging is a multifactorial process involving the skin, subcutaneous tissues, facial fat compartments, muscles, ligaments, and skeletal structures. Integrated minimally invasive protocols are increasingly us...
Mucoceles are benign lesions caused by the accumulation of mucus such as saliva, and are common in children. Surgical intervention is effective but is not well tolerated by children because of its invasiveness, and alternative treatment methods are b...
Background: Head and neck cutaneous squamous cell carcinoma (HNcSCC) presents intersecting oncologic, functional, and reconstructive challenges. Although numerous clinicopathologic factors have been associated with recurrence, metastasis, and surviva...
Fractures of the lateral process of the talus are uncommon injuries. We present a direct force trauma-induced talus lateral process fracture sustained in a 60-year-old male. The fracture was eventually diagnosed with computed tomography (CT) imaging...
Background and Clinical Significance: Immediate implant placement in mandibular molars represents a clinical challenge due to lower trabecular bone density and anatomical limitations of the interradicular septum. Osseodensification has been proposed...
Background: Oral lichen planus (OLP) is a chronic inflammatory mucocutaneous disorder that is well documented in adults but remains relatively uncommon in the pediatric population. Due to its rarity, knowledge regarding its epidemiology, etiology, cl...
Background: Chronic nasopharyngeal inflammation (chronic epipharyngitis) is associated with various upper airway and systemic symptoms. However, the relationship between endoscopic inflammatory findings and functional respiratory abnormalities remain...
Background and Clinical Significance: Eczema herpeticum (EH), or Kaposi’s varicelliform eruption, is a dermatologic emergency characterized by the abrupt onset of painful monomorphic vesiculopustules with potential for rapid dissemination. Atop...
Background and Clinical Significance: Solitary fibrous tumor (SFT), historically termed hemangiopericytoma (HPC), is a rare fibroblastic mesenchymal neoplasm with variable biological behavior. Pulmonary involvement is uncommon and may represent eithe...
Background and Clinical Significance: Renal disease is the leading cause of secondary hypertension in children and adolescents. Among younger patients presenting with severe hypertension, renovascular and renal parenchymal disorders should be conside...
Background and Clinical Significance: Eosinophilic sialodochitis (ES), also known as sialodochitis fibrinosa, is a rare disorder characterized by recurrent salivary gland swelling caused by intraductal eosinophilic mucous plugs. Typical histopatholog...
Background and Clinical Significance: Proliferative fasciitis (PF) is an infrequent benign fibroblastic/myofibroblastic proliferation that may closely resemble a soft tissue sarcoma, creating a diagnostic dilemma out of proportion to its biological b...
Background and Clinical Significance: Peri-implantitis is an inflammatory condition associated, among other factors, with biofilm accumulation, affecting peri-implant soft and hard tissues and potentially leading to implant loss. Its treatment remain...
Background and Clinical Significance: Tooth surface loss is the irreversible loss of dental hard tissue caused by non-carious processes. Restoration of affected teeth can be challenging, especially on the palatal surfaces of maxillary anterior teeth...
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