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Tropical Medicine and Infectious Disease, Volume 10, Issue 3

2025 March - 25 articles

Cover Story: In their paper entitled “Sex-Specific Immune Responses Mediate Host Specificity in Hookworm Infections”, Langeland et al. explore sex-specific differences in how immune mechanisms influence hookworm infections. Using the immunodeficient Stat6 knockout mouse model, the researchers demonstrate that female mice support robust Ancylostoma ceylanicum infections, while males are less susceptible, suggesting a role of sex-dependent immune responses. This study also shows that A. caninum does not rely on host immune factors for establishment, indicating fundamental differences in hookworm species adaptation. These findings provide new insights into the role of sex-specific aspects of innate immunity in hookworm infections that could inform targeted therapeutic strategies. View this paper
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Articles (25)

  • Article
  • Open Access
1 Citations
1,411 Views
12 Pages

Clinical Characteristics of Nontuberculous Mycobacterial Positivity Occurring During Multidrug-Resistant Tuberculosis Treatment: A Retrospective Study

  • Min Wang,
  • Muhammad Tahir Khan,
  • Zilong Yang,
  • Zhiyu Feng,
  • Hong Zhang,
  • Yuan Yuan,
  • Di Wu,
  • Zeying Chen,
  • Haobin Kuang and
  • Shouyong Tan

The clinical characteristics of multidrug-resistant tuberculosis (MDR-TB) patients with concurrent nontuberculous mycobacterial (NTM) infection present significant challenges to treatment. This study investigated the clinical characteristics of MDR-T...

  • Review
  • Open Access
4 Citations
2,403 Views
14 Pages

Antimicrobial Resistance and Its Impact on Food Safety Determinants Along the Beef Value Chain in Sub-Saharan Africa—A Scoping Review

  • Godfrey Musuka,
  • Jairus Machakwa,
  • Oscar Mano,
  • Patrick Gad Iradukunda,
  • Pierre Gashema,
  • Enos Moyo,
  • Amon Nsengimana,
  • Shepherd Manhokwe,
  • Tapiwa Dhliwayo and
  • Tafadzwa Dzinamarira

Antimicrobial resistance (AMR) poses a significant threat to human, animal, and public health, particularly in Sub-Saharan Africa (SSA), where the beef sector is vital to food security and livelihoods. We conducted a scoping review to explore the det...

  • Review
  • Open Access
2 Citations
3,867 Views
21 Pages

Alterations and Dynamics of Major Meningitis Etiological Agents During and Post-COVID-19 Pandemic: A Systematic Review

  • Luís Arthur Brasil Gadelha Farias,
  • Larissa Santos Weyne,
  • Lenifer Siqueira Landim,
  • Pablo Eliack Linhares de Holanda,
  • Aliniana da Silva Santos,
  • Luciano Pamplona de Góes Cavalcanti,
  • Lourrany Borges Costa,
  • Antonio Gutierry Neves Dantas de Melo,
  • Melissa Soares Medeiros and
  • Lauro Vieira Perdigão Neto
  • + 2 authors

The transmission dynamics of many pathogens were altered during the coronavirus disease 2019 (COVID-19) pandemic. Several factors, including control measures and social distancing, have influenced the circulation and epidemiology of major etiological...

  • Article
  • Open Access
1 Citations
2,131 Views
11 Pages

A High Burden of Infectious Tuberculosis Cases Among Older Children and Young Adolescents of the Female Gender in Ethiopia

  • Zewdu Dememew,
  • Atakilt Deribew,
  • Amtatachew Zegeye,
  • Taye Janfa,
  • Teshager Kegne,
  • Yohannes Alemayehu,
  • Asfawosen Gebreyohannes,
  • Sidhartha Deka,
  • Pedro Suarez and
  • Dan Schwarz
  • + 1 author

The study was conducted in all regions of Ethiopia, except Tigray. It describes types of Tuberculosis (TB) based on gender, age, region, HIV status, and geographic setting in Ethiopia. It is a cross-sectional study that utilized the Ministry of Healt...

  • Review
  • Open Access
5 Citations
5,574 Views
16 Pages

Treatment Adherence and Outcomes in Patients with Tuberculosis Treated with Telemedicine: A Scoping Review

  • Kikelomo Sabainah Olowoyo,
  • Deborah Tolulope Esan,
  • Paul Olowoyo,
  • Babatunji Emmanuel Oyinloye,
  • Israel Opeyemi Fawole,
  • Segun Aderibigbe,
  • Mary Opeyemi Adigun,
  • David Bamidele Olawade,
  • Theophilus Olaide Esan and
  • Benedict Tolulope Adeyanju

Patient non-adherence to drug usage is a major barrier to treating tuberculosis (TB). Telemedicine has shown promise in treatment monitoring and evaluation. This paper aims to explore scientific evidence of telemedicine application in TB treatment to...

  • Article
  • Open Access
3 Citations
2,607 Views
13 Pages

Dog-Mediated Rabies Surveillance in Nigeria (2014–2023): Investigating Seasonality and Spatial Clustering

  • Rebecca D. Williams,
  • Mahbod Entezami,
  • Ruth Alafiatayo,
  • Olaniran Alabi,
  • Daniel L. Horton,
  • Emma Taylor,
  • Rachel Tidman,
  • Columba T. Vakuru,
  • Taiwo Olasoju and
  • Joaquin M. Prada
  • + 1 author

Rabies is an important zoonotic disease responsible for 59,000 human deaths worldwide each year. More than a third of these deaths occur in Africa. The first step in controlling rabies is establishing the burden of disease through data analysis and i...

  • Review
  • Open Access
3 Citations
2,227 Views
11 Pages

Generalized Treatment as Prevention Plus Focused Pre-Exposure Prophylaxis Is the Key to Controlling HIV/AIDS

  • Julio S. G. Montaner,
  • Viviane D. Lima,
  • Kate A. Salters,
  • Junine Toy,
  • Jeffrey B. Joy,
  • Silvia Guillemi and
  • Rolando Barrios

Treatment as Prevention (TasP) and Pre-Exposure Prophylaxis (PrEP) are both widely recognized as essential biomedical tools to control HIV/AIDS. TasP calls for the immediate initiation of fully subsidized and supported antiretroviral therapy (ART) fo...

  • Review
  • Open Access
3 Citations
2,651 Views
37 Pages

Do Statins Affect Viral Infections Encountered by International Travelers?

  • Chinmay T. Jani,
  • Christian Mouchati,
  • Nour Abdallah,
  • Ruchi Jani,
  • Loukas Kakoullis and
  • Lin H. Chen

Statins are among the most frequently prescribed medications. In addition to their well-established effectiveness in lowering total cholesterol, LDL, and triglycerides, statins have been described to have immunomodulatory and anti-inflammatory proper...

  • Brief Report
  • Open Access
1,683 Views
6 Pages

Streamlining Preparedness: A Practical Pathway to Special Pathogens Management

  • Sarah Irene Brown,
  • Priya Dhagat,
  • Aishani V. Aatresh,
  • Saoirse Bodnar and
  • Syra Madad

Managing special pathogens cases, also known as high consequence infectious diseases, presents unique challenges for healthcare systems. It requires thorough planning and comprehensive operational protocols, as well as an appreciation of how human an...

  • Systematic Review
  • Open Access
1,704 Views
16 Pages

The Utility of Infectious Disease Prevalence Studies to Inform Public Health Decision-Making in the Samoan Islands: A Systematic Review

  • Beatris Mario Martin,
  • Alison Brown,
  • Filipina Amosa-Lei Sam,
  • Aifili Tufa,
  • Luis Furuya-Kanamori and
  • Colleen L. Lau

We conducted a systematic review of infectious disease (ID) prevalence studies in the Samoan Islands from 2000 to 2024 and aimed to synthesise the prevalence of IDs, the purpose of the studies, and the potential utility of survey results for informin...

  • Systematic Review
  • Open Access
2 Citations
1,364 Views
16 Pages

Sensitivity of Immunodiagnostic Tests in Localized Versus Disseminated Tuberculosis—A Systematic Review of Individual Patient Data

  • Michael Eisenhut,
  • Shagun Shah,
  • Ozge Kaba,
  • Manolya Kara,
  • Murat Sütçü,
  • Kyoung-Ho Song,
  • Hong Bin Kim and
  • Maoshui Wang

Our objective was to perform a systematic review of individual patient data comparing immunodiagnostic test sensitivity in patients with localized versus disseminated tuberculosis who are from high- and less-than-high-income countries. In a systemati...

  • Article
  • Open Access
2 Citations
1,110 Views
9 Pages

Melioidosis is an endemic tropical disease caused by Burkholderia pseudomallei. It typically causes pulmonary disease and bacteraemia but can disseminate to cause multi-organ disease. 18-F FDG PET/CT has an evolving role in diagnosing other infectiou...

  • Article
  • Open Access
4 Citations
2,555 Views
16 Pages

Process Evaluation of Pragmatic Cluster-Randomized Trials of Digital Adherence Technologies for Tuberculosis Treatment Support: A Mixed-Method Study in Five Countries

  • Norma Madden,
  • Amare W. Tadesse,
  • Chung Lam Leung,
  • Bianca Gonçalves Tasca,
  • Jason Alacapa,
  • Natasha Deyanova,
  • Nontobeko Ndlovu,
  • Nontobeko Mokone,
  • Baraka Onjare and
  • Katherine Fielding
  • + 3 authors

Digital adherence technologies (DATs) could improve the person-centeredness of tuberculosis (TB) treatment. DATs are found to be acceptable, though evidence of their effectiveness is varied. Our objective was to understand the fidelity of DAT interve...

  • Article
  • Open Access
2,853 Views
14 Pages

Syndemic Factors Associated with Zika Virus Infection Prevalence and Risk Factors in a Cohort of Women Living in Endemic Areas for Arboviruses in Northeast Brazil

  • Ligia Kerr,
  • Carlos Sanhueza-Sanzana,
  • Marto Leal,
  • Italo Aguiar,
  • Kasim Allel,
  • Moisés H. Sandoval,
  • Cristiane Cunha Frota,
  • Marco Túlio Aguiar,
  • Adriano Ferreira Martins and
  • Carl Kendall
  • + 17 authors

Background: We sought to explain the seroprevalence of Zika Virus (ZIKV) as a syndemic of socioeconomic, environmental, and health factors in a cohort of women living in Brazil. Methods: This is a cohort study comprising 1498 women between 15 and 39...

  • Article
  • Open Access
4 Citations
3,045 Views
14 Pages

Estimating Dengue Outbreak Thresholds in West Africa: A Comprehensive Analysis of Climatic Influences in Burkina Faso, 2018–2024

  • John Otokoye Otshudiema,
  • Watton R. Diao,
  • Sonia Marie Wend-Kuuni Ouedraogo,
  • Alain Ngoy Kapete,
  • Laurent Moyenga,
  • Emmanuel Chanda,
  • Tieble Traore,
  • Otim Patrick Ramadan and
  • Alimuddin Zumla

Background: Dengue, transmitted by Aedes spp. mosquitoes, poses significant public health challenges in Burkina Faso. This study investigated outbreak thresholds, utilizing historical data since 2018 to explore the climatic impacts on dengue transmis...

  • Article
  • Open Access
2 Citations
2,798 Views
11 Pages

The Association Between Syphilis Infection and HIV Acquisition and HIV Disease Progression in Sub-Saharan Africa

  • Sindhuri Gandla,
  • Raja Nakka,
  • Ruhul Ali Khan,
  • Fatemeh Salboukh and
  • Musie Ghebremichael

Syphilis and other sexually transmitted infections (STIs) are highly prevalent in most regions experiencing severe human immunodeficiency virus (HIV) epidemics. In sub-Saharan Africa, the region most heavily affected by HIV, the prevalence of syphili...

  • Article
  • Open Access
2 Citations
2,309 Views
12 Pages

The Etiology and Antimicrobial Susceptibility of Community-Onset Urinary Tract Infections in a Low-Resource/High-Resistance Area of Latin America

  • Maria Micieli,
  • Selene Rebecca Boncompagni,
  • Tiziana Di Maggio,
  • Yenny Bertha Mamani Ramos,
  • Antonia Mantella,
  • Ana Liz Villagrán,
  • Carmen Angélica Revollo Yelma,
  • Evelin Esther Fortún Fernández,
  • Michele Spinicci and
  • Alessandro Bartoloni
  • + 3 authors

Urinary tract infections (UTIs) are common and are typically treated empirically, based on local antimicrobial resistance (AMR) data, which are often scarce in low- and middle-income countries. This study examines the AMR patterns of pathogens causin...

  • Article
  • Open Access
1 Citations
2,319 Views
14 Pages

The Comparative Performance of Klypson 500WG and 2GARD-WP Sprayed on Different Wall Surfaces Against Anopheles gambiae s.l. in Lower Moshi, Northern Tanzania

  • Maua J. Mohamed,
  • Deokary J. Matiya,
  • Fred D. Chibwana,
  • Winfrida Kidima,
  • Aneth M. Mahande and
  • Eliningaya J. Kweka

The emergence of insecticide resistance among malaria vector populations poses a significant threat to existing malaria vector control tools. This phenomenon necessitates an increased pace of developing and deploying new effective compounds in insect...

  • Article
  • Open Access
3 Citations
1,552 Views
11 Pages

Genetic Characterization and Zoonotic Potential of Leptospira interrogans Identified in Small Non-Flying Mammals from Southeastern Atlantic Forest, Brazil

  • Maria Isabel Nogueira Di Azevedo,
  • Ana Clara dos Reis Soares,
  • Camila Ezepha,
  • Filipe Anibal Carvalho-Costa,
  • Anahi Souto Vieira and
  • Walter Lilenbaum

Leptospirosis is a zoonotic disease of global public health importance caused by bacteria of the genus Leptospira. Small non-flying mammals are important reservoirs of the pathogen. The Brazilian Atlantic Forest is a biodiversity hotspot located in a...

  • Article
  • Open Access
1 Citations
1,958 Views
9 Pages

The aim of this study was to investigate the distribution of human papillomavirus (HPV) genotypes among cervical cancer cases in Moroccan women living in the Souss-Massa region. A total of 155 formalin-fixed, paraffin-embedded cervical tissue samples...

  • Article
  • Open Access
1,796 Views
12 Pages

Sex-Specific Immune Responses Mediate Host Specificity in Hookworm Infections

  • Andrea Langeland,
  • Catherine A. Jackson,
  • Elise L. McKean,
  • Hajar Errahmani,
  • Damien M. O’Halloran and
  • John M. Hawdon

Hookworm infections affect 500–700 million people worldwide and can lead to chronic conditions, such as malnutrition and anemia. The challenge of managing these infections is heightened by the absence of effective vaccines and the potential for...

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Trop. Med. Infect. Dis. - ISSN 2414-6366