Journal of Fungi, Volume 8, Issue 9
September 2022 - 94 articles
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Cover Story: The precise transmission of chromosomes during eukaryotic cell division depends on a several-mega-dalton-big molecular machine named the kinetochore. This structure connects chromosomes to spindle microtubules and in yeasts comprises more than 60 proteins organized in subcomplexes such as the CCAN. This paper uncovers inositol pyrophosphates (IPPs) as regulators for the kinetochore association of CCAN members. IPPs are highly energetic signaling molecules affecting numerous cellular processes. Specific IPPs generated by the Schizosaccharomyces pombe PPIP5K enzyme member modulate kinetochore association of CCAN proteins such as Mal2CENP-O in an inversely correlated manner. Thus, IPPs can alter kinetochore architecture which might impact chromosome transmission fidelity. View this paper