Special Issue "Recent Advances in Fundamental Research and Biotechnological Applications in Debaryomyces hansenii"

A special issue of Journal of Fungi (ISSN 2309-608X). This special issue belongs to the section "Fungal Genomics, Genetics and Molecular Biology".

Deadline for manuscript submissions: 31 July 2022.

Special Issue Editors

Prof. Dr. Jose Ramos
E-Mail Website
Guest Editor
Departament of Microbiology, E.T.S.I.A.M., University of Cordoba, E-14071 Cordoba, Spain
Interests: salt tolerance; ion homeostasis; food and D. hansenii interactions
Dr. José Luis Martinez
E-Mail Website
Guest Editor
Technical University of Denmark, Department of Biotechnology and Biomedicine, Søltofts Plads Building 223, 2800 Kgs. Lyngby, Denmark
Interests: fermentation technology; yeast cell factories; metabolic engineering; protein production; stress responses; HTS and automation
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Special Issue Information

Dear Colleagues,

Debaryomyces hansenii is a hemiascomycetous yeast of undoubted scientific relevance. Many peculiarities around this yeast are so attractive that basic and applied research is gaining momentum: it is a heterogeneous yeast species whose performance is improved in the presence of high salt, allowing it to survive extreme conditions such as low pH, higher temperatures, nutrient scarcity, and the presence of certain fermentation inhibitors derived from lignocellulosic biomass degradation.

D. hansenii has the highest coding capacity among yeast, with 6906 detected coding sequences, and the molecular characterization of this yeast is still far from being fully known. In fact, the number of well-characterized genes/proteins from D. hansenii is still very low and limited to a few families. D. hansenii belongs to the ambiguous CUG decoding group of yeasts, in which CUG codon can be ambiguously translated, mainly as serine but also as leucine, although in a small percentage. The difficulties when trying to advance in the study of D. hansenii’s metabolism have been mainly related to the limitations in the availability of highly efficient molecular tools. Additionally, several reports have described the misidentification of D. hansenii, which sets an additional level of difficulty in understanding the metabolic insights of this yeast’s peculiar behavior.

Although its biotechnological potential is still difficult to assess, due to the impossibility (to date) of implementing recombinant biosynthetic pathways allowing production of non-native products of interest at industrial scale, this yeast is currently very attractive in the food industry, where it is used in the ripening process of sausages and dry meat products. The use of D. hansenii as a biocontrol agent and to manufacture new meat products by decreasing the use of preservatives are examples of exploring research lines that will complement current knowledge and contribute to prepare new and more ecological products.

This aim of this Special Issue is to provide an interdisciplinary tool for sharing the most recent advances both in fundamental and applied research in relation to this particular yeast. As guest editors of this Special Issue, we invite you to submit original research articles, review articles, and short communications related to the isolation and screening of new D. hansenii strains, physiological characterization, -omics studies, the design of novel genome engineering methodologies, and/or bioprocess development related to the potential use of Debaryomyces for industrial  applications. 

Prof. Dr. Jose Ramos
Dr. José Luis Martinez
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Fungi is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • Debaryomyces hansenii
  • non-conventional yeast
  • stress responses
  • industrial biotechnology
  • yeast physiology

Published Papers

This special issue is now open for submission.
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