2026 October - 57 articles
Cardiomyopathies are genetically heterogeneous myocardial diseases that can lead to heart failure, arrhythmias, and sudden cardiac death. OBSCN encodes obscurin, a giant sarcomere-associated protein involved in sarcomere organization, cytoskeletal co...
Congenital heart disease (CHD) and neurodevelopmental disorders (NDDs) frequently co-occur, indicating that cardiac and neural phenotypes can arise from shared developmental disturbances rather than exclusively from the physiological consequences of...
Temporary mechanical circulatory support devices are increasingly used to stabilise haemodynamics in patients with compromised cardiac output. While devices vary regarding indications and haemodynamic effects, only left ventricular (LV) unloading by...
Background: Colchicine has demonstrated anti-inflammatory and cardiovascular benefits in patients with coronary heart disease. However, evidence regarding its effects on postoperative inflammation and early clinical outcomes following coronary artery...
Major surgery imposes physiological stress requiring coordinated adaptation of the cardiovascular, respiratory, hematological, and musculoskeletal systems. Conventional preoperative assessment remains essential but may underestimate heterogeneity in...
Background: Populations with the highest cardiovascular risk are often the least likely to take part in preventive care, a pattern described by the inverse care law. Delivering prevention in trusted community settings may improve reach. Methods: This...
Population-based studies of acute coronary syndrome (ACS) are often limited by the lack of structured left ventricular ejection fraction (LVEF) data in administrative registries. We developed a logistic regression model using ICD-10-CM diagnostic cod...
Background: As a rare disease, cardiac amyloidosis (CA) has seen a deepening of epidemiological understanding, driven by advances in imaging and genetic testing, alongside drug development. However, the identification of suspected patients in the ear...
Introduction: Transposition of the great arteries (TGA) is one of the most common cyanotic congenital heart diseases in the neonatal period, and arterial switch operation (ASO) is the standard surgical treatment. Postoperative low cardiac output synd...
Background: Detailed operative evidence comparing invasive anatomy and reconstruction between bicuspid aortic valve (BAV) and tricuspid aortic valve (TAV) cases of native-valve infective endocarditis is limited. We examined the association of BAV mor...
Background: Moderate-to-severe tricuspid regurgitation (TR) and renal dysfunction are each associated with adverse outcomes after transcatheter aortic valve replacement (TAVR). We investigated whether their coexistence identifies a clinically relevan...
Heart failure with preserved or mildly reduced ejection fraction (HFpEF/HFmrEF) accounts for approximately half of the global heart failure burden and remains a syndrome with limited device-based therapeutic options. It is often characterized by a di...
Background and Purpose: Abnormality in the motion of the inferior papillary muscle was found in an early study of mitral valve prolapse (MVP). We visually observed an abnormal movement not only in the inferior wall but also in the anterolateral and i...
Background: Atrial fibrillation (AF) is the most common sustained arrhythmia in hypertrophic cardiomyopathy (HCM), occurring in 20–25% of patients and associated with increased morbidity, stroke risk, and symptom burden. Despite this substantia...
Mitral valve prolapse (MVP) is a common congenital valve disorder that has been linked to defects in primary cilia during cardiac development, yet the mechanisms connecting ciliary regulation to valvulogenesis remain incompletely understood. As DZIP1...
Background: Pulsed electric field (PEF) has been investigated as a local ablation modality in various biomedical applications. Atherosclerotic plaques are composed of pathological cells, including macrophages, vascular smooth muscle cells (SMCs) and...
Aims: Accurate prediction of the clinical course in implantable cardioverter-defibrillator (ICD) and cardiac resynchronization therapy-defibrillator (CRT-D) patients is crucial, as their disease progression varies significantly due to comorbidities a...
Background: Restenosis and occlusion remain important after aortoiliac stenting, and device choice does not fully explain late patency loss. Lipoprotein(a) [Lp(a)] is implicated in atherosclerotic progression and residual vascular risk. Objective: To...
Myocardial strain imaging has become an established tool for detecting subtle abnormalities in cardiac mechanics, and reduced strain is frequently interpreted as evidence of subclinical myocardial dysfunction. However, myocardial deformation reflects...
Atrial fibrillation (AF) is increasingly understood as the electrical expression of a systemic and atrial cardiometabolic disease rather than an isolated disorder of pulmonary-vein triggers. Obesity, insulin resistance, hypertension, sleep-disordered...
Abdominal aortic aneurysm (AAA) is a spatially heterogeneous disease of the aortic wall for which no pharmacological treatment has reliably arrested enlargement. The term oxidative stress encompasses processes that differ in chemical form, anatomical...
Kounis syndrome is an acute coronary syndrome occurring in temporal association with an allergic or anaphylactic reaction. Recognition may be particularly challenging in patients with established coronary artery disease, in whom hypersensitivity-medi...
Objective: This study aimed to characterise thrombophilic variants in young patients (≤50 years) undergoing mechanical thrombectomy (MT) for acute ischaemic stroke and to determine their clinical relevance. In addition, outcomes in young patients...
Scimitar syndrome is a rare congenital form of partial anomalous pulmonary venous return characterized by right pulmonary venous drainage into the inferior vena cava, causing right-sided volume overload and increased risk of supraventricular arrhythm...
Background: Patients with systemic sclerosis (SSc) may be affected by pulmonary veno-occlusive disease (PVOD), a poorly characterized form of group I pulmonary arterial hypertension (PAH). This scoping review aimed to systematically map the literatur...
Atrial fibrillation (AF) is the most commonly encountered arrhythmia, with a rapidly growing prevalence and significant cost to the global healthcare system. Left untreated, AF progresses over time from paroxysmal AF to persistent AF (perAF) and long...
Background/objective: Cardiovascular disease (CVD) remains a major cause of death in Hungary and Iraq, which differ markedly in demographic structure, socioeconomic context, and health-system capacity. This study compared annual age-standardized card...
We describe a case of severe invasive infection caused by livestock-associated methicillin-resistant Staphylococcus aureus (LA-MRSA, ST398 lineage) in a patient with occupational exposure to pigs. The patient presented with confusion and clinical fin...
Background: This study aimed to investigate the relationship between partial aortic clamping (PAC) and single aortic clamping (SAC) techniques during isolated coronary artery bypass grafting (CABG) and their impact on clinical outcomes. Methods: Betw...
(1) Introduction and objectives: The most common practice after a complex ablation procedure (CAP) is next-day discharge (NDD) following an appropriate observation period. However, the use of same-day discharge (SDD) has increased substantially since...
Stress echocardiography has traditionally been used to identify inducible regional wall motion abnormalities caused by flow-limiting epicardial coronary artery disease. However, a substantial proportion of patients with angina or objective evidence o...
Background: Primary non-adherence (PNA)—failure to dispense a newly prescribed medication—is an early barrier to effective treatment. This study aimed to estimate PNA to oral anticoagulants in patients with atrial fibrillation (AF) in Ger...
(1) Background: The association between microaxial flow pump (mAFP) timing and outcomes in acute myocardial infarction-related cardiogenic shock (AMI-CS) remains uncertain. (2) Methods: We conducted a retrospective single-center study of patients wit...
Aortic valve disease (AVD), including bicuspid aortic valve (BAV) and aortic regurgitation (AR), presents a complex challenge in sports cardiology. Balancing the cardiovascular benefits of physical activity with the hemodynamic risks associated with...
Background: Because an uncovered arch scaffold does not provide a covered seal across an unresected arch tear, we evaluated a source-adjudicated sequential eligibility framework separating study-defined stop gates from residual-risk modifiers. Method...
Pleural adhesions can complicate access in robotic cardiac surgery, risking lung injury or conversion to sternotomy. The sliding test using thoracic ultrasound can predict thoracic adhesions and guide the surgeon during robotic set-up. We evaluated t...
Cardiovascular diseases remain the leading cause of mortality worldwide, with myocardial infarction (MI) representing one of the most severe manifestations. Oxidative stress, inflammation, and apoptosis are major contributors to myocardial injury. Py...
Elevated blood pressure (BP) and its variability are established stroke risk factors; however, whether long-term BP patterns are associated with stroke onset in patients with type 2 diabetes remains unclear. As a post hoc analysis, we conducted a nes...
Mitral valve prolapse (MVP) and mitral annular disjunction (MAD) are common comorbidities that can lead to serious cardiac arrhythmias and sudden cardiac death (SCD). Arrhythmic MVP is characterized by the presence of MVP with frequent (over 5% ventr...
Background/Objectives: Aortic aneurysm (AA) involves inflammatory recruitment and vascular smooth muscle cell (VSMC) remodeling, but the cellular contribution of candidate chemokine receptors remains unclear. We prioritized reproducible AA-associated...
Acute kidney injury (AKI) is common after cardiac surgery. We assessed the association between the preoperative advanced lung cancer inflammation index (ALI) and postoperative AKI. This retrospective cohort included adults undergoing cardiac surgery...
Heart failure with preserved ejection fraction (HFpEF) is a primary cause in patients with metabolic dysfunction and hypertension. A chronic high fat diet (HFD) creates metabolic dysfunction and dysregulation of epigenetic folate 1-carbon metabolism...
New-onset atrial fibrillation (NOAF) is a frequent complication among patients with non-ST-elevation myocardial infarction (NSTEMI) and is associated with adverse outcomes, making early identification of predictors essential for risk stratification a...
Background: The molecular basis of myocarditis is often associated with genetic cardiomyopathies and truncating or loss-of-function variants in the titin gene (TTNtv/lof). Here, we hypothesize that titin serum levels increase in patients with myocard...
Background: Aortic valve regurgitation is a common valvular heart disease. Transcatheter aortic valve replacement (TAVR) and surgical aortic valve replacement (SAVR) are the principal therapeutic modalities, while the comparative efficacy of these tw...
Background/Objectives: This prospective study evaluated the feasibility of a non-contrast 5T one-stop MRA protocol for simultaneous assessment of the thoracic aorta and coronary arteries and examined the effect of heart rate (HR) on image quality. Me...
As survival after left ventricular assist device (LVAD) implantation improves, an increasing number of patients require non-cardiac surgery (NCS) during follow-up. This study aimed to evaluate the clinical characteristics and perioperative management...
Background: Atrial fibrillation (AF) is associated with progressive remodeling of the left atrium (LA). Pulmonary vein isolation (PVI) is an established rhythm-control strategy; however, its long-term impact on LA mechanical and hemodynamic function...
Background: Females are at increased risk of patient–prosthesis mismatch (PPM) following surgical aortic valve replacement (AVR) due to anatomical complexities. Whilst sutureless valves can reduce risk in smaller annuli, the literature lacks se...
Large language models (LLMs), including ChatGPT, Gemini, and DeepSeek, are increasingly used in medicine; however, their performance across multiple clinically relevant domains remains incompletely understood. This cross-sectional comparative study e...
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