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Acute Myocardial Infarction: Pharmacological and Interventional Treatment
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Acute Myocardial Infarction: Pharmacological and Interventional Treatment

A special issue of Journal of Cardiovascular Development and Disease (ISSN 2308-3425).

Deadline for manuscript submissions: 30 June 2025 | Viewed by 1087

Special Issue Editors

Dr. Antonino Nicosia

E-Mail Website
Guest Editor
Cardiology Department, Cardio-Neuro-Vascular Institute, Giovanni Paolo II Hospital, ASP 7 Ragusa, 97100 Ragusa, Italy
Interests: complex and high-risk indicated procedures; acute coronary syndromes; peripheral interventions; artificial intelligence in medicine; calcific lesions
Dr. Giuseppe Giacchi

E-Mail Website
Guest Editor Assistant
Cardiology Department, Cardio-Neuro-Vascular Institute, Giovanni Paolo II Hospital, ASP 7 Ragusa, 97100 Ragusa, Italy
Interests: complex and high-risk indicated procedures; acute coronary syndromes; structural interventions; mechanical circulatory support; calcific lesions

Special Issue Information

Dear Colleagues,

Acute myocardial infarction remains a major concern for the cardiologists and the modern societies, primarily due to its higher periprocedural mortality and the increased risk of long-term complications, such as congestive heart failure. Despite the advancements in treating acute coronary syndromes with improved drugs and innovative percutaneous devices, it continues to be the leading cause of death and disability in Western countries. This underscores the need for a comprehensive, integrated approach that combines pharmacological therapies with advanced technical interventions, in order to improve both short-term outcomes and long-term clinical results.

The aim of this Special Issue is to provide a modern and detailed overview of current trends in the treatment of acute coronary syndromes. It offers a comprehensive review of interventional options and available pharmacological therapies. By addressing both clinical and technical perspectives, this issue aims to offer up-to-date knowledge and practical insights for enhancing patient care.

Through this Special Issue, readers will gain a deeper understanding of the evolving strategies in the treatment of acute myocardial infarction, allowing them to better address the challenges posed by this life-threatening condition and ultimately improve patient outcomes.

Dr. Antonino Nicosia
Guest Editor

Dr. Giuseppe Giacchi
Guest Editor Assistant

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Cardiovascular Development and Disease is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • acute coronary syndromes (ACS)
  • ST-segment elevation myocardial infarction (STEMI)
  • thrombotic coronary lesions
  • antithrombotic therapy
  • antiplatelet therapy
  • thrombus aspiration
  • mechanical thrombus aspiration
  • rheolytic thrombectomy

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Further information on MDPI's Special Issue policies can be found here.

Published Papers (2 papers)

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10 pages, 560 KiB  
Article
Impact of Revascularization on Major Adverse Cardiovascular Events in Patients Without ST-Elevation Myocardial Infarction in the Arabian Gulf
by Ibrahim Al-Zakwani, Fahad AlKindi, Wael Almahmeed and Mohammad Zubaid
J. Cardiovasc. Dev. Dis. 2025, 12(4), 117; https://doi.org/10.3390/jcdd12040117 - 27 Mar 2025
Viewed by 252
Abstract
Objectives: The study evaluated the impact of revascularization procedures, including percutaneous coronary intervention (PCI) and coronary artery bypass graft (CABG), during the index hospitalization on major adverse cardiovascular events (MACE) in patients with non-ST-elevation myocardial infarction (NSTEMI) in the Arabian Gulf. Methods [...] Read more.
Objectives: The study evaluated the impact of revascularization procedures, including percutaneous coronary intervention (PCI) and coronary artery bypass graft (CABG), during the index hospitalization on major adverse cardiovascular events (MACE) in patients with non-ST-elevation myocardial infarction (NSTEMI) in the Arabian Gulf. Methods: Data were analyzed from 1820 consecutive patients diagnosed with NSTEMI, admitted to 29 hospitals in four Arabian Gulf countries from January 2012 to January 2013, and who were discharged alive. Results: Of the patients, 29.1% (n = 529) underwent either PCI (89.8%; n = 475) or CABG (10.2%; n = 54). The matching method (288 PCI/CABG patients were matched with 762 controls that did not undergo PCI/CABG) revealed significant reductions in MACE events among patients who had undergone PCI/CABG (25% vs. 43%; p < 0.001). This decrease was consistent across individual MACE components, including stroke/transient ischemic attack (TIA) (2.4% vs. 7.0%; p = 0.005), all-cause mortality (4.5% vs. 7.0%; p < 0.001) and cardiac-related readmissions (20% vs. 31%; p = 0.001) but not reinfarction (1.7% vs. 1.4%; p = 0.73). Conclusions: The revascularization procedures, PCI/CABG, were associated with significant reductions in annual MACE event rates, specifically lower stroke/TIA, all-cause mortality and cardiac-related readmissions. Full article
(This article belongs to the Special Issue Acute Myocardial Infarction: Pharmacological and Interventional Treatment)
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11 pages, 4248 KiB  
Case Report
Safety and Effectiveness of a Peripheral Rheolytic Thrombectomy Catheter in ST-Segment Elevation Myocardial Infarction: A Case Series
by Giuseppe Giacchi, Agnese Bentivegna, Ida Logatto and Antonino Nicosia
J. Cardiovasc. Dev. Dis. 2025, 12(2), 72; https://doi.org/10.3390/jcdd12020072 - 14 Feb 2025
Viewed by 530
Abstract
Percutaneous treatment of highly thrombotic coronary lesions is demanding, due to worse acute and long-term clinical outcomes. In this report, we describe a case series of six patients with ST-segment elevation myocardial infarction and high-thrombus-burden coronary lesions. All patients were treated with the [...] Read more.
Percutaneous treatment of highly thrombotic coronary lesions is demanding, due to worse acute and long-term clinical outcomes. In this report, we describe a case series of six patients with ST-segment elevation myocardial infarction and high-thrombus-burden coronary lesions. All patients were treated with the AngioJet Solent® Dista catheter, a rheolytic thrombectomy device designed for peripheral use. The catheter effectively reduced the thrombus burden in all cases, achieving satisfactory final angiographic results. One case of no-reflow was observed following lesion dilatation prior to thrombectomy, but no other major in-hospital adverse events occurred. At mid-term follow-up, all patients remained free from angina. These preliminary findings suggest that this approach could represent a promising option for managing highly thrombotic coronary lesions, but further studies with larger populations and long-term follow-up are needed to confirm these results. Full article
(This article belongs to the Special Issue Acute Myocardial Infarction: Pharmacological and Interventional Treatment)
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