Atrial Fibrillation Ablation Beyond Pulmonary Vein Isolation: From Mechanisms to Advanced Mapping, Navigation and Robotics

A Special Issue of Journal of Cardiovascular Development and Disease (ISSN 2308-3425) belonging to the section "Electrophysiology and Cardiovascular Physiology".

Deadline for manuscript submissions: 15 May 2027 | Viewed by 52

Editors


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Guest Editor
Department of Internal Medicine, Cardiology Centre, University of Szeged, Szeged, Hungary
Interests: robotic magnetic navigation; advanced cardiac mapping; dipole charge density mapping; source mapping; catheter ablation; atrial fibrillation; ventricular arrhythmias; non-contact mapping technologies

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Guest Editor Assistant
Department of Cardiology, Clinical Rehabilitation Hospital, Cluj-Napoca, Romania
Interests: atrial fibrillation; atrial remodeling; advanced cardiac mapping; catheter ablation; ventricular arrhythmias; robotic magnetic navigation; dipole charge density mapping

Special Issue Information

Dear Colleagues,

Cardiac arrhythmias remain a major cause of morbidity and mortality worldwide and continue to represent a significant clinical and socioeconomic burden. Catheter ablation has become a cornerstone therapy for the management of cardiac arrhythmias, offering effective rhythm control and improved quality of life for patients with both supraventricular and ventricular arrhythmias. Rapid advances in mapping technologies, imaging integration, energy delivery systems, and artificial intelligence–assisted approaches continue to expand the safety, efficacy, and clinical applicability of ablation procedures.

This Special Issue aims to provide an updated overview of current advances, emerging technologies, and future perspectives in the field of catheter-based arrhythmia management. The topic is closely aligned with the scope of JCDD by addressing translational and clinical aspects of cardiovascular disease, electrophysiology, and innovative therapeutic strategies.

In this Special Issue, original research articles, reviews, systematic reviews, meta-analyses, and clinical studies are welcome. Research areas may include, but are not limited to, the following:

  • Atrial fibrillation ablation;
  • Ventricular tachycardia ablation;
  • Supraventricular tachycardia ablation;
  • Pulsed field ablation;
  • Electroanatomical mapping technologies;
  • Intracardiac and multimodality imaging;
  • Substrate characterization and modification;
  • Artificial intelligence and computational modeling in electrophysiology;
  • Complications and safety of catheter ablation;
  • Long-term outcomes and rhythm monitoring;
  • Personalized approaches in arrhythmia management;
  • Novel energy sources and future directions in ablation therapy.

We look forward to receiving your contributions.

Prof. Dr. Tamás Szili-Török
Guest Editor

Dr. Ioan Alexandru Minciună
Guest Editor Assistant

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Keywords

  • catheter ablation
  • cardiac arrhythmias
  • atrial fibrillation
  • ventricular tachycardia
  • electrophysiology
  • pulsed-field ablation
  • electroanatomical mapping
  • supraventricular tachycardia
  • robotic magnetic navigation
  • atrial remodeling

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Published Papers (1 paper)

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Review

21 pages, 1484 KB  
Review
Hybrid Ablation for Patients with Persistent and Long-Standing Persistent Atrial Fibrillation
by Ji-Cheng Hsieh, James K. Gabriels, Kristie Coleman, Stuart Beldner, Frank Manetta and Stavros E. Mountantonakis
J. Cardiovasc. Dev. Dis. 2026, 13(10), 505; https://doi.org/10.3390/jcdd13100505 - 8 Oct 2026
Abstract
Atrial fibrillation (AF) is the most commonly encountered arrhythmia, with a rapidly growing prevalence and significant cost to the global healthcare system. Left untreated, AF progresses over time from paroxysmal AF to persistent AF (perAF) and long-standing persistent AF (LS-perAF). AF is associated [...] Read more.
Atrial fibrillation (AF) is the most commonly encountered arrhythmia, with a rapidly growing prevalence and significant cost to the global healthcare system. Left untreated, AF progresses over time from paroxysmal AF to persistent AF (perAF) and long-standing persistent AF (LS-perAF). AF is associated with significant mortality and morbidity by increasing the risk of developing cardiomyopathy, heart failure, dementia, stroke and systemic embolization. Endocardial catheter ablation (CA) targeting pulmonary vein isolation (PVI) alone is the most commonly employed treatment strategy for patients undergoing invasive treatment for all forms of AF. Despite technological improvements such as pulsed field ablation (PFA), procedural success rates in preventing AF recurrences in patients with perAF and LS-perAF remain suboptimal. A lack of lesion transmurality gives rise to epicardial–endocardial dissociation, which may contribute to AF recurrences. Hybrid ablation (HA) combines epicardial surgical ablation with endocardial CA. HA leads to greater freedom from AF in advanced AF compared to CA, and while existing data support the safety of HA, HA inherently is more invasive, requires a multidisciplinary approach, and has a 5–7.8% risk of major adverse events. HA is reasonable in patients with symptomatic, drug-refractory perAF or LS-perAF. Future directions include evaluating the role of novel operative technologies in HA. Full article
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