Novel Insights into Heart Failure with Preserved Ejection Fraction (HFpEF): From Pathophysiology to Precision Management

Dear Colleagues,

Heart Failure with Preserved Ejection Fraction (HFpEF) represents one of the most challenging and increasingly prevalent syndromes in contemporary cardiovascular medicine. Despite preserved left ventricular ejection fraction, patients experience significant morbidity, recurrent hospitalizations, impaired quality of life, and high mortality. The heterogeneity of HFpEF reflects the complex interplay between myocardial dysfunction, vascular abnormalities, systemic inflammation, metabolic disturbances, renal impairment, aging, obesity, and other comorbidities, making accurate diagnosis, risk stratification, and therapeutic decision-making particularly demanding.

This Special Issue, “Novel Insights into Heart Failure with Preserved Ejection Fraction (HFpEF): From Pathophysiology to Precision Management”, aims to highlight recent advances in the understanding, diagnosis, and management of HFpEF. We welcome original research, reviews, and translational studies focusing on disease mechanisms, phenotyping, biomarkers, imaging, exercise physiology, comorbidity-driven pathways, emerging pharmacological and non-pharmacological therapies, and personalized treatment strategies. Through this collection, we seek to promote a deeper understanding of HFpEF and support the development of more precise, patient-centered approaches to improve clinical outcomes.

Prof. Dr. Ioannis Paraskevaidis
Dr. Christos Kourek
Guest Editors

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