Bioengineering Platforms for Drug Delivery

A special issue of Bioengineering (ISSN 2306-5354). This special issue belongs to the section "Nanobiotechnology and Biofabrication".

Deadline for manuscript submissions: 20 February 2026 | Viewed by 2066

Special Issue Editor


E-Mail Website
Guest Editor
Centre for Pharmaceutical Innovation, Clinical and Health Sciences, University of South Australia, Adelaide 5000, Australia
Interests: drug delivery; nanomedicine; lipid nanoparticles; inorganic nanoparticles; antimicrobial resistance (AMR); biofilms; microbiology assays; hydrogels; wound infections

Special Issue Information

Dear Colleagues,

Drug delivery is a progressive field in contemporary medicine that has improved clinical relevance and brought new hope for the treatment of intractable diseases. As therapeutic strategies evolve toward precision medicine, integrated delivery systems are urgently needed to achieve controlled and precise drug delivery. However, drug delivery still faces multiple challenges, including insufficient bioavailability and targeting accuracy, rapid degradation of therapeutic drugs, and potential side effects. More significantly, they also need to overcome physiological barriers such as the blood–brain barrier, combat multidrug resistance of microorganisms and cancer cells, and ensure a stable and effective delivery mechanism. Conventional methods have their own limitations, especially cytotoxicity, which may reduce therapeutic efficacy and endanger patient safety. Considering these challenges, the fields of nanotechnology and bioengineering are being explored to develop sophisticated, adaptable, and effective drug delivery platforms to achieve precision medicine and personalized treatment. Recent advances in nanotechnology and bioengineering are dedicated to overcoming current limitations, such as key challenges of systemic toxicity and physiological barriers, providing the ability to precisely target, regulate drug release, and achieve synergistic drug co-loading. These improvements are essential to improve biocompatibility and optimize cellular uptake, thereby addressing multifaceted challenges in medical interventions.

Anam Ahsan
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Bioengineering is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • biomaterials
  • drug delivery
  • nanotechnology
  • nanobiotechnology
  • bioengineering platforms
  • targeted drug delivery
  • chemotherapy
  • bioconjugation
  • disease management
  • therapeutic agents

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • Reprint: MDPI Books provides the opportunity to republish successful Special Issues in book format, both online and in print.

Further information on MDPI's Special Issue policies can be found here.

Published Papers (2 papers)

Order results
Result details
Select all
Export citation of selected articles as:

Research

Jump to: Review

31 pages, 7625 KB  
Article
Phytogenic Silver Nanoparticles Derived from Ricinus communis and Aloe barbadensis: Synthesis, Characterization, and Evaluation of Biomedical Potential
by Anam Ahsan, George F. Gao and Wen-Xia Tian
Bioengineering 2025, 12(11), 1273; https://doi.org/10.3390/bioengineering12111273 - 19 Nov 2025
Viewed by 873
Abstract
The green synthesis of silver nanoparticles (SNPs) using medicinal plants provides a sustainable and eco-friendly approach to nanoparticle production with promising biomedical potential. In this study, Ricinus communis and Aloe barbadensis aqueous leaf extracts were employed as reducing and stabilizing agents to synthesize [...] Read more.
The green synthesis of silver nanoparticles (SNPs) using medicinal plants provides a sustainable and eco-friendly approach to nanoparticle production with promising biomedical potential. In this study, Ricinus communis and Aloe barbadensis aqueous leaf extracts were employed as reducing and stabilizing agents to synthesize R. communis SNPs (RcSNPs) and A. barbadensis SNPs (AbSNPs). The nanoparticles were characterized using ultraviolet–visible spectroscopy, dynamic light scattering, Fourier-transform infrared spectroscopy, scanning electron microscopy, transmission electron microscopy, thermogravimetric analysis, and differential scanning calorimetry to evaluate their physicochemical and thermal properties. RcSNPs and AbSNPs were predominantly spherical, with average sizes of 15–20 nm and 23–28 nm, respectively, and exhibited stability up to ~90 °C. Biological evaluations demonstrated potent antimicrobial, antioxidant, anti-inflammatory, anti-tyrosinase, and cytotoxic activities. Notably, RcSNPs and AbSNPs induced apoptosis through mitochondrial pathway modulation and showed superior cytotoxicity compared to crude plant extracts and several previously reported SNPs. These findings indicate that phytochemical-mediated SNPs not only provide a green route of synthesis but also exhibit multifunctional bioactivities, which may support their potential applications as antimicrobial, antioxidant, depigmenting, and anticancer agents in biomedical and pharmaceutical fields. Full article
(This article belongs to the Special Issue Bioengineering Platforms for Drug Delivery)
Show Figures

Graphical abstract

Review

Jump to: Research

25 pages, 359 KB  
Review
The Gastrointestinal Tract: A Unique Battlefield for Bioengineering Delivery Platforms
by Teng Ma and Siyu Sun
Bioengineering 2025, 12(12), 1347; https://doi.org/10.3390/bioengineering12121347 - 10 Dec 2025
Viewed by 291
Abstract
Traditional drug delivery methods for gastrointestinal diseases, including oral and systemic administration, often suffer from degradation, inadequate mucosal absorption, and off-target toxicity. Consequently, these methods result in low bioavailability and suboptimal therapeutic outcomes for localized conditions such as inflammation and early-stage cancer. This [...] Read more.
Traditional drug delivery methods for gastrointestinal diseases, including oral and systemic administration, often suffer from degradation, inadequate mucosal absorption, and off-target toxicity. Consequently, these methods result in low bioavailability and suboptimal therapeutic outcomes for localized conditions such as inflammation and early-stage cancer. This review examines the innovative integration of advanced bioengineering platforms with therapeutic gastrointestinal endoscopy to address these delivery challenges. We concentrate on three principal bioengineered platforms: (1) nanoparticle systems (e.g., lipid, polymeric, and inorganic nanoparticles) designed for localized chemotherapy and theranostics; (2) in situ-forming hydrogels that serve as intelligent wound management materials and sustained drug depots; and (3) drug-eluting and biodegradable stents that convert passive luminal scaffolds into active, long-term drug-releasing devices. An analysis of these platforms demonstrates that their synergy with endoscopy facilitates precise, minimally invasive, and sustained local therapy, potentially transforming the treatment landscape for gastrointestinal diseases such as cancer and inflammatory bowel disease. Additionally, we investigate advanced strategies, including active targeting and stimulus-responsive release mechanisms, to enhance spatial precision. Despite promising preclinical advancements, clinical translation encounters challenges related to long-term biocompatibility, scalable manufacturing, regulatory pathways for drug-device combinations, and cost-effectiveness. Ultimately, the convergence of bioengineering and endoscopy presents significant potential to usher in a new era of precise, localized, and sustained micro-invasive treatments in gastroenterology. Full article
(This article belongs to the Special Issue Bioengineering Platforms for Drug Delivery)
Show Figures

Graphical abstract

Back to TopTop