Table of Contents
Plants, Volume 8, Issue 5 (May 2019)
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Cover Story (view full-size image) In plants, the downregulation of genes mediated by microRNAs (miRNAs) is mainly achieved through [...] Read more. In plants, the downregulation of genes mediated by microRNAs (miRNAs) is mainly achieved through the cleavage and degradation of their target transcripts. However, some miRNA-targeting events do not lead to mRNA degradation, but instead act as the trigger to a process known as transitivity, where the target transcript serves as template for the production of secondary small interfering RNAs (siRNAs). The existence of this process has important consequences, adding interesting new features to the gene regulation mediated by miRNAs. In this review, these features, the mechanisms leading to miRNA-triggered production of secondary siRNAs, and methods to downregulate genes using this silencing mechanism will be discussed. View this paper.