Biomolecules, Volume 16, Issue 8
2026 August - 147 articles
Cover Story: The cardiovascular consequences of surgery may begin long before the patient enters the operating room. Chronic stress may be an overlooked cardiovascular risk factor in patients undergoing noncardiac surgery. This review integrates mechanistic, epidemiological, and emerging clinical evidence showing that chronic stress can dysregulate the HPA axis and promote glucocorticoid resistance, sympathetic activation, systemic inflammation, endothelial dysfunction, autonomic imbalance, and hypercoagulability—pathways that converge with postoperative myocardial injury, arrhythmias, and thromboembolic events. A critical unanswered question is whether identifying and reducing preoperative chronic stress can improve postoperative cardiovascular outcomes—an area requiring prospective studies and randomized trials. View this paper
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Biomolecules - ISSN 2218-273X