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Bioactive Compounds with Application Potentials in Nutraceuticals and Nutricosmetics: Focus...
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Department of Food Science and Technology, Korea National University of Transportation, Jeungpyeong-gun, Chungbuk, Republic of Korea
Food Science and Technology Center, National University of Singapore Suzhou Research Institute, Suzhou 215123, China
School of Chemistry, Chemical Engineering and Biotechnology, Nanyang Technological University, Singapore 637459, Singapore
Dr. Pujie Shi
Center for Engineered Therapeutics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA
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Bioactive Compounds with Application Potentials in Nutraceuticals and Nutricosmetics: Focus on Mechanism of Action and Application Science—2nd Edition

Abstract submission deadline
31 October 2026
Manuscript submission deadline
31 December 2026
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565

Topic Information

Dear Colleagues,

As biological compounds isolated from natural plants, nutraceuticals offer numerous benefits such as preventing chronic disease, delaying aging, extending lifespan, improving health, and supporting body structures and functions. As nutricosmetics can be used as nutritional supplements to provide adequate nutrients for nails, hair, and skin, as well as work from within the body to add beauty, future trends in the health and beauty industry will revolve around nutraceuticals and nutricosmetics. Bio-active compounds are key factors for the development of nutraceuticals or nutricosmetics, as well as some functional foods. This Special Issue invotes recent studies covering, but not limited to, the following sub-topics:

(1) The bioactivities of compounds from edible natural products including ethnopharmacology and folk medicine with long histories of ingestion;
(2) Functional mechanism studies of nutraceutical and nutricosmetic via biochemical analysis in vitro/vivo/silico or evidence-based clinical trials;
(3) The process of biosynthesis and the formulation of nutraceuticals, nutricosmetics, or biocompatible cosmetic materials;
(4) Advanced technologies for improving the stability and functionality of bioactive products for application.

Prof. Dr. Hyun-Gyun Yuk
Prof. Dr. Caili Fu
Dr. Lin Chen
Dr. Pujie Shi
Topic Editors

Keywords

  • nutraceuticals
  • nutricosmetic
  • biocompatible
  • stability
  • extending lifespan
  • chronic disease
  • skin health
  • antioxidant

Participating Journals

Journal Name Impact Factor CiteScore Launched Year First Decision (median) APC
Foods
foods 		4.7 7.4 2012 14.5 Days CHF 2900 Submit
International Journal of Molecular Sciences
ijms 		4.9 8.1 2000 16.8 Days CHF 2900 Submit
Nutrients
nutrients 		4.8 9.2 2009 13.5 Days CHF 2900 Submit
Biomolecules
biomolecules 		4.8 9.4 2011 18.4 Days CHF 2700 Submit
BioChem
biochem 		- - 2021 21.7 Days CHF 1000 Submit
Molecules
molecules 		4.2 7.4 1996 15.1 Days CHF 2700 Submit

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Published Papers (1 paper)

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Article
Long-Term Supplementation of GABA Regulates Growth, Food Intake, Locomotion, and Lipid Metabolism by Increasing Ghrelin and Growth Hormone in Adolescent Mice
by Rafael Begazo-Jimenez, Amelia Yu, Robert Gros and Wei-Yang Lu
Nutrients 2025, 17(10), 1634; https://doi.org/10.3390/nu17101634 - 10 May 2025
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Abstract
Background/Objectives: The amino acid γ-aminobutyric acid (GABA) is the primary neurotransmitter in the central nervous system (CNS) and acts as an autocrine and/or paracrine signaling molecule in various types of non-neuronal cells. On the other hand, GABA is a nutrient found in [...] Read more.
Background/Objectives: The amino acid γ-aminobutyric acid (GABA) is the primary neurotransmitter in the central nervous system (CNS) and acts as an autocrine and/or paracrine signaling molecule in various types of non-neuronal cells. On the other hand, GABA is a nutrient found in a variety of foods and is marketed as a health supplement based on a growing number of studies reporting health benefits in humans and recuperations in animal models of diseases. The present study sought to examine whether supplementation of GABA to young mice regulates their growth as well as glucose and lipid metabolism during physiological adolescence. Methods: Mice were supplemented with GABA over a 16-week period with subsequent anthropometric, metabolic, and endocrine measurements. Results: Results showed that 16-week oral supplementation of GABA increased food consumption and body length while attenuating weight gain in male mice but not females. In addition, GABA treatment lowered the index of body fat (Lee index) and increased the expression of lipolytic enzymes in adipose and liver tissues of male mice without affecting blood glucose levels. Remarkably, supplementation of GABA significantly increased the protein expression of growth hormone (GH) in the pituitary gland of both male and female mice. However, it only substantially increased GH levels in the sera of male mice but not females. Moreover, GABA significantly increased the expression of the GH secretagogue peptide ghrelin in the stomachs of male mice only. Conclusions: Together these novel findings suggest that long-term GABA supplementation fundamentally influences the growth and lipid metabolism of males during adolescent development by stimulating ghrelin–GH production and secretion. The mechanisms of GABA-induced sex-dependent upregulations of ghrelin and GH, as well as lipid metabolism in adolescence, await further studies. Full article
(This article belongs to the Topic Bioactive Compounds with Application Potentials in Nutraceuticals and Nutricosmetics: Focus on Mechanism of Action and Application Science—2nd Edition)
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