Topic Editors

School of Medicine, Shanghai University, Shanghai 200444, China
Department of Orthopaedic Surgery, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA

Bone-Related Diseases: From Molecular Mechanisms to Therapy Development—2nd Edition

Abstract submission deadline
31 October 2026
Manuscript submission deadline
31 December 2026
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734

Topic Information

Dear Colleagues,

The prevalence and incidence of bone-related diseases (fractures, osteoarthritis, osteoporosis, bone tumors, etc.) are increasing with the current developments in society, especially in the aging population. These diseases often result in pain and disability and incapacitate people in their daily life, which imposes a considerable global socioeconomic burden. Therefore, it is imperative to explore the biomarkers and molecular mechanisms for early diagnosis and targeted treatment of bone-related diseases. With the rise in systematic biology and bioinformatics, more analytical techniques, including single-cell sequencing (scSeq), cytometry by time-of-flight (CyTOF), and bulk RNA-Seq, have been applied to achieve a deeper understanding of the mechanisms of these diseases, such as their genomics, proteomics, metabolomics, and transcriptomics. Particularly, molecular mechanisms of bone-related diseases could be identified from the analysis of genes, proteins, metabolites, etc. In this Topic, we welcome original research or review articles relating to new insights into pathogenesis, potential biomarkers, and recent advances in the study of bone-related diseases. The submission of original articles, reviews, mini-reviews, and commentaries is welcomed. Topics of interest include but are not limited to the following:

  • Mechanism of action research, including molecular and cellular mechanisms and key signaling pathways in bone-related diseases.
  • Novel therapeutic strategies in the treatment of bone-related diseases.
  • Biomarker studies in bone tumors and other bone-related diseases.
  • Drug development, including PD, PK, toxicity, and efficacy evaluation, for osteoarthritis, osteoporosis, and other bone-related diseases.
  • Clinical trials, including on osteoarthritis, osteoporosis, and bone tumors.

Dr. Xin Dong
Dr. Xiao Wang
Topic Editors

Keywords

  • bone-related diseases
  • osteoporosis
  • osteoarthritis
  • multi-omics analysis
  • biomarkers
  • early diagnosis
  • molecular mechanisms
  • clinical trials

Participating Journals

Journal Name Impact Factor CiteScore Launched Year First Decision (median) APC
Biomolecules
biomolecules
4.8 9.2 2011 19.4 Days CHF 2700 Submit
International Journal of Molecular Sciences
ijms
4.9 9.0 2000 20.5 Days CHF 2900 Submit
Journal of Clinical Medicine
jcm
2.9 5.2 2012 17.7 Days CHF 2600 Submit
Biomedicines
biomedicines
3.9 6.8 2013 17 Days CHF 2600 Submit
Osteology
osteology
- - 2021 22.3 Days CHF 1000 Submit
Cells
cells
5.2 10.5 2012 16 Days CHF 2700 Submit

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Published Papers (1 paper)

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17 pages, 1174 KB  
Brief Report
Novel SNP Combination for Predictive Osteoporotic Diagnosis
by Julia V. Sopova, Olga A. Krasnova, Polina I. Semenova, Julia D. Kryukova, Giomar V. Vasileva, Anna S. Zhuk, Olga M. Lesnyak, Vitaliy V. Karelkin and Irina E. Neganova
Int. J. Mol. Sci. 2025, 26(22), 11117; https://doi.org/10.3390/ijms262211117 - 17 Nov 2025
Viewed by 432
Abstract
Osteoporosis is a multifactorial disease, the pathogenesis of which is caused by a complex interaction of genetic, hormonal, and metabolic factors. The challenges of early diagnosis highlight the need to identify genetic predictors to prevent bone mineral density (BMD) loss. Given the critical [...] Read more.
Osteoporosis is a multifactorial disease, the pathogenesis of which is caused by a complex interaction of genetic, hormonal, and metabolic factors. The challenges of early diagnosis highlight the need to identify genetic predictors to prevent bone mineral density (BMD) loss. Given the critical role of G-protein-coupled receptors (GPCRs) in bone development and remodeling, we investigated osteoporosis-associated single-nucleotide polymorphisms (SNPs) within GPCR genes using next-generation sequencing of patient cohorts. Subsequent screening via Sanger sequencing identified three SNPs for further analysis: rs1991517 in the thyroid-stimulating hormone receptor gene (TSHR), rs6166 in the follicle-stimulating hormone receptor gene (FSHR), and rs1042713 in the β2-adrenergic receptor gene (ADRB2). Our results reveal a significant association between osteoporosis and a specific homozygous genotype combination (TSHR rs1991517 CC, FSHR rs6166 AA, and ADRB2 rs1042713 AA). The functional impairment in osteodifferentiation was further validated in patient-derived cell lines harboring this triple-SNP combination. Thus, this study is the first to identify a specific combination of GPCR gene polymorphisms that may serve as a predictive biomarker for osteoporosis in early genetic screening. Full article
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