- 4.8Impact Factor
- 9.2CiteScore
- 20 daysTime to First Decision
Biomolecules, Volume 14, Issue 1
January 2024 - 138 articles
Cover Story: Piezo1 is a mechanosensitive ion channel required for various biological processes, but its regulation remains poorly understood. Here, we used erythrocytes to address this question since they display Piezo1 clusters, a strong and dynamic cytoskeleton and three types of submicrometric lipid domains, respectively, enriched in cholesterol, GM1 ganglioside/cholesterol and sphingomyelin/cholesterol. We revealed that Piezo1 was differentially controlled by lipid domains and the cytoskeleton and was favored by the stomatocyte–discocyte–echinocyte transformation. Our study opens the way to elucidate the deregulation of Piezo1–cytoskeleton–lipid domain interplay in patients with hereditary xerocytosis and in Piezo1-related diseases such as beta-thalassemia and sickle cell disease. View this paper
- Issues are regarded as officially published after their release is announced to the table of contents alert mailing list .
- You may sign up for email alerts to receive table of contents of newly released issues.
- PDF is the official format for papers published in both, html and pdf forms. To view the papers in pdf format, click on the "PDF Full-text" link, and use the free Adobe Reader to open them.
Articles
There are no articles in this issue yet.
Get Alerted
Add your email address to receive forthcoming issues of this journal.
Biomolecules - ISSN 2218-273X