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Biomolecules, Volume 13, Issue 7

2023 July - 144 articles

Cover Story: In this article, we provide a comprehensive analysis of heme-binding motifs (HBMs) in mammalian proteins, which can help in deciphering the recognition mechanisms for the initial association of heme to target proteins and the constitution of the resulting complexes. The pivotal role of Cys-Pro dipeptide motifs is highlighted together with a comparative insight into the sequences and structural anomalies observed in all types of HBMs. A general consensus sequence depending on the coordination site Cys, His, or Tyr, which can be used to predict HBMs more accurately using machine learning algorithms, can be established. To further fortify the studies involving structural pattern recognition, the availability and quality of protein 3D structures is paramount, despite the usefulness of AlphaFold. View this paper
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Biomolecules - ISSN 2218-273X
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