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Biomolecules, Volume 13, Issue 11
November 2023 - 116 articles
Cover Story: Narcolepsy type 1 (NT1) is a sleep disease distinguished by sudden muscle weakness known as cataplexy. The study examined serum samples obtained from 16 patients with NT1 and 11 healthy individuals. By using hydrophilic interaction liquid chromatography (HILIC) and LC-MS/MS techniques to quantify certain glycopeptide structures, 28 distinct N-glycopeptides showed notable alternations when comparing the two cohorts. These findings highlight the molecular pathways associated with NT1 and the pathophysiological effects of specific glycopeptides. The results provide valuable insights into the functional significance of glycoproteins in the context of NT1, thus potentially contributing to future advancements of diagnostic and therapeutic approaches. View this paper
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Biomolecules - ISSN 2218-273X