Dear Colleagues,

We are pleased to invite you to submit a review or research article to the Special Issue entitled “Advances in Plasma Bioscience and Medicine”, which we are organizing in collaboration with Biomolecules (IF 6.064; https://www.mdpi.com/journal/biomolecules), an open access journal published by MDPI, Switzerland.

Plasma medicine, i.e., the biomedical application of non-thermal atmospheric pressure plasma (NTP), is gaining increasing interest, with applications in sterilization of microorganisms (i.e., bacteria, fungi and viruses), food decontamination, wound healing and even cancer treatment.

It is widely accepted that the biological and medical effects of NTP are related to reactive oxygen and nitrogen species (RONS). While high doses of NTP-generated RONS are undeniably "harmful" to any cell/organism, delivery of low doses of specific RONS may be beneficial in the aforementioned therapies.

The argument follows that RONS regulate key biochemical pathways within intra- and intercellular environments, inducing chemical and physical modifications in cellular components, oxidizing or breaking them into fragments. Studies have already shown that the treatment of living cells with NTP induces changes in intracellular signaling, which is important in the treatment of diseases. However, it is still unclear how plasma-generated RONS regulate intracellular processes. If these processes are better understood, it will allow the development of more targeted and effective medical plasma therapy.

In this Special Issue of Biomolecules, we aim to offer a platform for high-quality publications focused on the fundamental understanding of the impact of NTP-generated RONS on biomolecules or the implications of these interactions in the context of plasma medicine.

Research areas may include (but are not limited to) the following:

• Plasma medicine
• Plasma oncology
• Plasma disinfection
• Plasma wound healing
• Plasma immunotherapy
• Plasma-activated liquid

We look forward to receiving your contributions.

Dr. Maksudbek Yusupov
Dr. Jamoliddin Razzokov
Dr. Pankaj Attri
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomolecules is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2300 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

• non-thermal (cold) atmospheric pressure plasma
• reactive oxygen and nitrogen species (RONS)
• plasma–biomolecule interaction
• plasma cancer treatment
• plasma immunomodulation
• plasma inactivation of viruses, fungi and bacteria
• plasma–liquid interaction
• computer simulations

Title: Cold Atmospheric Plasma's Chemical Modifications on Molecules and Their Biological Effects.
Authors: Dayun Yan, Li Lin, Marisa Lazarus, Ruby Limanowski, Alex Horkowitz, William Murphy, Michael Keidar.
Affiliation: George Washington University, Department of Mechanical and Aerospace Engineering, Department of Biomedical Engineering, Department of Physics.