Histone Modifications in Health and Diseases
A special issue of Biomolecules (ISSN 2218-273X). This special issue belongs to the section "Biomacromolecules: Proteins".
Deadline for manuscript submissions: closed (30 June 2024) | Viewed by 12101
Special Issue Editors
Interests: epigenetics; histone modifications; vascular biology; gastroenterological disorders; metabolic diseases
Interests: SMYD proteins; structure and function relationships; data science
Special Issues, Collections and Topics in MDPI journals
Interests: epigenetics; cancer biology; gastroenterological disorders; animal disease models
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Histones undergo a variety of post-translational modifications (PTMs), the covalent modifications on certain residues of histone proteins, including acetylation, methylation, phosphorylation, ubiquitylation, sumoylation, glycosylation, and ADP-ribosylation, among others. These PTMs can impact gene expression by altering chromatin structure and function, regulating transcription and other nuclear processes, recruiting reader/binding proteins, etc.
Histone PTMs are dynamically regulated by specific modifying enzymes whose activities require metabolites that either serve as co-substrates or act as activators/inhibitors. Aberrant histone modifications are linked to the pathogenesis and progression of a multitude of human diseases such as cancers, cardiovascular diseases, autoimmune diseases, as well as other inflammatory and metabolic disorders. Thus, elucidating the molecular mechanisms underlying histone modifications in health and disease conditions is critical to understanding disease pathogenesis and the development of novel therapeutics.
This Special Issue on “Histone Modifications in Health and Diseases” aims to provide new insights into the mechanisms and dysregulation of various histone modifications in human health and diseases. Authors are invited to submit original research and review articles related to these subjects. The topics of interest include (but are not limited to) novel aspects and mechanisms of histone modifications, role of histone posttranslational modifications in disease development, crosstalk between different histone modifications and its role in health and disease, application of activators/inhibitors of histone-modifying enzymes in disease control, etc.
Dr. Chunying Li
Dr. Zhe Yang
Dr. Yuning Hou
Guest Editors
Manuscript Submission Information
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Keywords
- histone modifications
- lysine methylation
- lysine acetylation
- histone phosphorylation
- histone ubiquitylation
- histone sumoylation
- human diseases
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