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Metabolites, Volume 15, Issue 1

January 2025 - 66 articles

Cover Story: The invasive species Ailanthus altissima releases volatile organic compounds (VOCs) that significantly inhibit the germination rates of Bidens pilosa, a common weed, in a dose-dependent manner. This study reveals that VOCs disrupt key metabolic pathways in seeds, delaying starch breakdown and reducing energy availability. A metabolomic analysis showed alterations in the TCA cycle, glycolysis, and amino acid metabolism, which are essential for early seed development. This study not only shows how VOC-mediated allelopathy may contribute to A. altissima's ecological dominance but also sheds light on the ecological strategies of invasive species, offering new perspectives on managing plant invasions and promoting sustainable ecosystem balance. View this paper
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Articles (66)

  • Article
  • Open Access
2 Citations
2,473 Views
17 Pages

Osteopenia Metabolomic Biomarkers for Early Warning of Osteoporosis

  • Jie Wang,
  • Dandan Yan,
  • Suna Wang,
  • Aihua Zhao,
  • Xuhong Hou,
  • Xiaojiao Zheng,
  • Jingyi Guo,
  • Li Shen,
  • Yuqian Bao and
  • Wei Jia
  • + 3 authors

20 January 2025

Introduction: This study aimed to capture the early metabolic changes before osteoporosis occurs and identify metabolomic biomarkers at the osteopenia stage for the early prevention of osteoporosis. Materials and Methods: Metabolomic data were genera...

  • Article
  • Open Access
1,935 Views
20 Pages

20 January 2025

Background: Postoperative ileus (POI) is a common postoperative clinical complication that significantly affects postoperative rehabilitation and quality of life in patients and can even produce secondary complications, leading to serious consequence...

  • Article
  • Open Access
3 Citations
2,214 Views
13 Pages

20 January 2025

Background: Despite antihypertensive treatment, some high-risk hypertensive patients still experience major adverse cardiovascular events (MACEs). Current risk stratification tools may underestimate the presence of metabolites in hypertension and the...

  • Article
  • Open Access
2 Citations
1,850 Views
18 Pages

17 January 2025

The inherent deficiency of phospholipids in Artemia limits its nutritional value as live prey for marine fish larvae. In our previous study, we optimized a phospholipid enrichment method by incubating Artemia nauplii with 10 g of soybean lecithin per...

  • Article
  • Open Access
6 Citations
2,570 Views
21 Pages

LC-MS-Based Global Metabolic Profiles of Alternative Blood Specimens Collected by Microsampling

  • Marlene N. Thaitumu,
  • Daniel Marques De Sá e Silva,
  • Philippine Louail,
  • Johannes Rainer,
  • Glykeria Avgerinou,
  • Anatoli Petridou,
  • Vassilis Mougios,
  • Georgios Theodoridis and
  • Helen Gika

16 January 2025

Blood microsampling (BμS) has recently emerged as an interesting approach in the analysis of endogenous metabolites but also in metabolomics applications. Their non-invasive way of use and the simplified logistics that they offer renders these tec...

  • Article
  • Open Access
5 Citations
8,812 Views
15 Pages

A Randomized, Placebo-Controlled, Single-Center, Crossover Study to Evaluate the Effects of Pre-Meal Whey Protein Microgel on Post-Prandial Glucometabolic and Amino Acid Response in People with Type 2 Diabetes and Overweight or Obesity

  • Ian J Neeland,
  • Luiz H de Gregório,
  • Roberto Zagury,
  • Bo Ahrén,
  • Joel Neutel,
  • Christian Darimont,
  • John Corthesy,
  • Yohan Grzywinski,
  • Emilie Perrin and
  • Maximilian von Eynatten
  • + 1 author

16 January 2025

Purpose: Whey protein (WP) consumption prior to a meal curbs appetite and reduces postprandial glucose (PPG) through stimulating endogenous GLP-1 secretion and insulin. Methods: We assessed the metabolic effects of a concentrated WP, using a new mice...

  • Article
  • Open Access
1 Citations
1,574 Views
14 Pages

Comparative Study of Lipid Profile for Mice Treated with Cyclophosphamide by HPLC-HRMS and Bioinformatics

  • Ekaterina Demicheva,
  • Fernando Jonathan Polanco Espino,
  • Pavel Vedeneev,
  • Vadim Shevyrin,
  • Aleksey Buhler,
  • Elena Mukhlynina,
  • Olga Berdiugina,
  • Alicia del Carmen Mondragon,
  • Alberto Cepeda Sáez and
  • Aroa Lopez-Santamarina
  • + 5 authors

16 January 2025

Purpose: Immunodeficiency conditions, which are characterized by reduced immune activity that promotes the development of chronic diseases, are needed for efficient monitoring. A promising area of monitoring and early diagnosis of immunodeficiency di...

  • Article
  • Open Access
1 Citations
1,454 Views
22 Pages

The Positive Regulatory Effect of DBT on Lipid Metabolism in Postpartum Dairy Cows

  • Zheng Zhou,
  • Kang Yong,
  • Zhengzhong Luo,
  • Zhenlong Du,
  • Tao Zhou,
  • Xiaoping Li,
  • Xueping Yao,
  • Liuhong Shen,
  • Shumin Yu and
  • Yixin Huang
  • + 1 author

16 January 2025

Background/Objectives: The transition from a non-lactating to a lactating state is a critical period for lipid metabolism in dairy cows. Danggui Buxue Tang (DBT), stimulating energy metabolism, ameliorates diseases related to lipid metabolism disorde...

  • Review
  • Open Access
7 Citations
4,916 Views
21 Pages

16 January 2025

Background/Objectives: Sarcopenia, characterized by the progressive loss of muscle mass and strength, is linked to physical disability, metabolic dysfunction, and an increased risk of mortality. Exercise therapy is currently acknowledged as a viable...

  • Article
  • Open Access
7 Citations
1,285 Views
15 Pages

Colostrum-Derived Melatonin Plus PEG Microspheres Modulate the Oxidative Metabolism of Human Colostrum Phagocytes

  • Caroline G. Silva,
  • Viviane F. Luz,
  • Victor L. Nunes,
  • Ana B. M. Verzoto,
  • Aron C. de M. Cotrim,
  • Wagner B. dos Santos,
  • Eduardo L. França and
  • Adenilda C. Honorio-França

16 January 2025

Background/Objectives: Exogenous melatonin adsorbed onto PEG microspheres can modulate the functional activity of phagocytes in colostrum, but no data are available on the activity of melatonin found in colostrum. Therefore, the objective of this stu...

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Metabolites - ISSN 2218-1989