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Metabolites, Volume 13, Issue 5

May 2023 - 96 articles

Cover Story: Bipolar disorder (BD) causes changes in a person's mood, energy, and ability to function, with a prevalence of 60 million people worldwide. Significant deficiency to understand and diagnose BD is based on the complexity of this disease, including diverse genetic, environmental, and biochemical factors, and establishing a diagnosis based on subjective recognition of symptoms without any clinical test of biomarker identification. An 1H-NMR-based metabolomic study applying chemometrics of serum samples of Serbian patients with BD was conducted, providing the identification of 22 metabolites for this disease. The same established nine metabolites in three different ethnic and geographic origins (Serbia, Brazil, and China) might have a crucial role in the realization of a universal set of NMR biomarkers for BD. View this paper
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Articles (96)

  • Article
  • Open Access
19 Citations
3,964 Views
24 Pages

Eight gene clusters responsible for synthesizing bioactive metabolites associated with plant growth promotion were identified in the Bacillus cereus strain D1 (BcD1) genome using the de novo whole-genome assembly method. The two largest gene clusters...

  • Review
  • Open Access
39 Citations
10,178 Views
46 Pages

The present study aims to provide a narrative review of the molecular mechanisms of Western diet-induced obesity and obesity-related carcinogenesis. A literature search of the Cochrane Library, Embase and Pubmed databases, Google Scholar and the grey...

  • Review
  • Open Access
26 Citations
5,835 Views
22 Pages

Trillions of diverse microbes reside in the gut and are deeply interwoven with the human physiological process, from food digestion, immune system maturation, and fighting invading pathogens, to drug metabolism. Microbial drug metabolism has a profou...

  • Article
  • Open Access
6 Citations
2,378 Views
15 Pages

Oregano (Origanum vulgare and O. onites) is one of the most frequently counterfeited herbs in the world and is diluted with the leaves of a wide variety of plants. In addition to olive leaves, marjoram (O. majorana) is often used for this purpose in...

  • Article
  • Open Access
1 Citations
2,185 Views
12 Pages

Clofazimine-Mediated, Age-Related Changes in Skeletal Muscle Mitochondrial Metabolites

  • Jennifer Diaz-Espinosa,
  • Kathleen A. Stringer and
  • Gus R. Rosania

Mitochondrial health declines with age, and older patients can demonstrate dysfunction in mitochondrial-rich tissues, such as cardiac and skeletal muscle. Aged mitochondria may make older adults more susceptible to adverse drug reactions (ADRs). We a...

  • Article
  • Open Access
3 Citations
2,539 Views
15 Pages

Plant species are sensitive to stresses, especially at the seedling stage, and they respond to these conditions by making metabolic changes to counteract the negative effects of this. The objectives of this study were to determine carbohydrate profil...

  • Article
  • Open Access
1 Citations
2,279 Views
11 Pages

Non-Targeted Metabolic Profiling of Cerebellum in Spina Bifida Fetal Rats

  • Evan Thielen,
  • Marc Oria,
  • Miki Watanabe-Chailland,
  • Kristin Lampe,
  • Lindsey Romick-Rosendale and
  • Jose L. Peiro

Spina bifida, known more commonly as myelomeningocele, is a neural tube defect that results in herniation of the cerebellum through the foramen magnum into the central canal as part of the Chiari II malformation. Effects stemming from the herniated c...

  • Article
  • Open Access
3 Citations
3,002 Views
16 Pages

Enhancement of Ambient Mass Spectrometry Imaging Data by Image Restoration

  • Yuchen Xiang,
  • Martin Metodiev,
  • Meiqi Wang,
  • Boxuan Cao,
  • Josephine Bunch and
  • Zoltan Takats

Mass spectrometry imaging (MSI) has been a key driver of groundbreaking discoveries in a number of fields since its inception more than 50 years ago. Recently, MSI development trends have shifted towards ambient MSI (AMSI) as the removal of sample-pr...

  • Article
  • Open Access
7 Citations
2,694 Views
20 Pages

Changes in the Secretion of Melatonin and Selected Adipokines during the Progression of Parkinson’s Disease—Preliminary Studies

  • Jan Milanowski,
  • Kamil Kozerawski,
  • Weronika Falęcka,
  • Dominik Dudek,
  • Beata Lisewska,
  • Paweł Lisewski,
  • Jarosław Nuszkiewicz,
  • Roland Wesołowski,
  • Jakub Wojtasik and
  • Celestyna Mila-Kierzenkowska
  • + 1 author

Parkinson’s disease (PD) is one of the most common neurodegenerative diseases affecting elderly people. Considering the gap in the literature on melatonin and adipokine levels in PD patients at various stages of the disease, we conducted a stud...

  • Article
  • Open Access
8 Citations
5,025 Views
16 Pages

Shades of Fine Dark Chocolate Colors: Polyphenol Metabolomics and Molecular Networking to Enlighten the Brown from the Black

  • Aecio Luís de Sousa Dias,
  • Julie-Anne Fenger,
  • Emmanuelle Meudec,
  • Arnaud Verbaere,
  • Pierre Costet,
  • Clotilde Hue,
  • Florent Coste,
  • Sophie Lair,
  • Véronique Cheynier and
  • Jean-Claude Boulet
  • + 1 author

High-quality dark chocolates (70% cocoa content) can have shades from light to dark brown color. This work aimed at revealing compounds that discriminate black and brown chocolates. From 37 fine chocolate samples from years 2019 and 2020 provided by...

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Metabolites - ISSN 2218-1989