Functional Foods and Diabetes II

A special issue of Metabolites (ISSN 2218-1989). This special issue belongs to the section "Food Metabolomics".

Deadline for manuscript submissions: closed (31 August 2023) | Viewed by 9112

Special Issue Editors


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Guest Editor
Department of Food Science, National Taiwan Ocean University, Keelung 202, Taiwan
Interests: lipid metabolism; nutrition; endocrinology and microbiology
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
National Taiwan Ocean University, Keelung, Taiwan
Interests: nutrition; endocrinology and microbiology
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Diabetes mellitus is known to be a common chronic metabolic disease, mainly manifested by hyperglycemia and often accompanied by the dysregulation of blood lipid metabolism. Growing evidence has shown that a high-carbohydrate diet does not provide any advantage in levels of blood glucose and plasma lipid compared to a high-fat diet for both type 1 and type 2 diabetic patients. A high-carbohydrate/high-fiber diet has been suggested to improve blood glucose control and suppress plasma cholesterol concentrations in diabetic patients compared with a low-carbohydrate/low-fiber diet. It has been suggested that water-soluble fiber is better for regulating glucose and lipid metabolism in humans. Moreover, is a ketogenic diet suitable for diabetic patients? Dietary intake is an important issue for glucose and lipid metabolism in diabetic patients.

Compared with that of basic nutrition, the consumption of functional foods promotes optimal health and reduces the risk of chronic diseases. In recent decades, bioactive components of functional foods have been greatly considered to control or even improve dysregulation of glucose and lipid metabolism. In this Special Issue, researchers are encouraged to submit manuscripts (both in the form of original research and review articles) focusing on properties of functional foods or dietary intake in control of various aspects of glucose and lipid metabolism in diabetes.

Prof. Dr. Meng-Tsan Chiang
Dr. Chung-Hsiung Huang
Guest Editors

Manuscript Submission Information

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Keywords

  • diabetes
  • functional foods
  • dietary intake
  • bioactive components
  • glucose metabolism
  • lipid metabolism

Published Papers (1 paper)

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Research

12 pages, 4504 KiB  
Article
Resveratrol Alleviates Advanced Glycation End-Products-Related Renal Dysfunction in D-Galactose-Induced Aging Mice
by Kuo-Cheng Lan, Pei-Jin Peng, Ting-Yu Chang and Shing-Hwa Liu
Metabolites 2023, 13(5), 655; https://doi.org/10.3390/metabo13050655 - 13 May 2023
Cited by 4 | Viewed by 8297
Abstract
The elderly have higher concentrations of advanced glycation end-products (AGEs). AGEs are considered risk factors that accelerate aging and cause diabetic nephropathy. The effects of AGEs on renal function in the elderly remain to be clarified. This study aimed to explore the role [...] Read more.
The elderly have higher concentrations of advanced glycation end-products (AGEs). AGEs are considered risk factors that accelerate aging and cause diabetic nephropathy. The effects of AGEs on renal function in the elderly remain to be clarified. This study aimed to explore the role of AGEs in renal function decline in the elderly and the protective effect of resveratrol, a stilbenoid polyphenol, comparing it with aminoguanidine (an AGEs inhibitor). A D-galactose-induced aging mouse model was used to explore the role of AGEs in the process of renal aging. The mice were administered D-galactose subcutaneously for eight weeks in the presence or absence of orally administered aminoguanidine or resveratrol. The results showed that the serum levels of AGEs and renal function markers BUN, creatinine, and cystatin C in the mice significantly increased after the administration of D-galactose, and this outcome could be significantly reversed by treatment with aminoguanidine or resveratrol. The protein expression levels for apoptosis, fibrosis, and aging-related indicators in the kidneys were significantly increased, which could also be reversed by treatment with aminoguanidine or resveratrol. These findings suggest that resveratrol could alleviate AGEs-related renal dysfunction through the improvement of renal cellular senescence, apoptosis, and fibrosis in D-galactose-induced aging in mice. Full article
(This article belongs to the Special Issue Functional Foods and Diabetes II)
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