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Scientia Pharmaceutica, Volume 85, Issue 1

March 2017 - 15 articles

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Articles (15)

  • Article
  • Open Access
4 Citations
7,497 Views
10 Pages

Stability Study and a 14-Day Oral Dose Toxicity in Rats of Plantain Leaf Extract (Plantago lanceolata L.) Syrup

  • Kenza Mansoor,
  • Fadi Qadan,
  • Mathias Schmidt,
  • Eyad Mallah,
  • Wael Abudayyih and
  • Khalid Matalka

Plants have been used since antiquity to treat and prevent diseases. Plantain (Plantago lanceolata L.) is traditionally used for the treatment of the common cold and associated symptoms such as cough. This study was designed to evaluate the oral toxi...

  • Article
  • Open Access
13 Citations
6,807 Views
7 Pages

Obesity is a major health problem in the US and globally. Obesity is associated with the risk of cardiovascular disease, type 2 diabetes, cancers, hyperlipidemia, and liver steatosis development. Dehydroepiandrosterone (DHEA) is a dietary supplement...

  • Article
  • Open Access
23 Citations
6,371 Views
9 Pages

Adverse drug reaction and resistance to antituberculosis drugs remain the causes of tuberculosis therapeutic failure. This research aimed to find the combination effect of standard antituberculosis drugs with Hibiscus sabdariffa L., Kaempferia galang...

  • Article
  • Open Access
30 Citations
8,221 Views
16 Pages

Alginate-based composite sponges were developed as carriers to prolong the gastric retention time and controlled release of curcumin-loaded self-microemulsifying drug delivery systems (Cur-SMEDDS). Liquid Cur-SMEDDS was incorporated into a solution m...

  • Article
  • Open Access
10 Citations
7,293 Views
12 Pages

n-Hexane Insoluble Fraction of Plantago lanceolata Exerts Anti-Inflammatory Activity in Mice by Inhibiting Cyclooxygenase-2 and Reducing Chemokines Levels

  • Nanang Fakhrudin,
  • Eny Dwi Astuti,
  • Rini Sulistyawati,
  • Djoko Santosa,
  • Ratna Susandarini,
  • Arief Nurrochmad and
  • Subagus Wahyuono

Inflammation is involved in the progression of many disorders, such as tumors, arthritis, gastritis, and atherosclerosis. Thus, the development of new agents targeting inflammation is still challenging. Medicinal plants have been used traditionally t...

  • Article
  • Open Access
15 Citations
4,288 Views
10 Pages

Serum Cystatin C as a Biomarker in Diffuse Large B-Cell Lymphoma

  • Nada E. Hammouda,
  • Manal A. Salah El-Din,
  • Mamdouh M. El-Shishtawy and
  • Amal M. El-Gayar

Elevated serum levels of cystatin C are found to be related to poor outcome and metastatic potential of some malignant disorders. To evaluate the clinical prominence of serum cystatin C in diffuse large B-cell lymphoma (DLBCL), blood samples were obt...

  • Article
  • Open Access
14 Citations
6,971 Views
10 Pages

Six-Month Chronic Toxicity Study of Tamarind Pulp (Tamarindus indica L.) Water Extract

  • Irene Iskandar,
  • Finna Setiawan,
  • Lucy D N Sasongko and
  • I Ketut Adnyana

Tamarind water extract has been shown to demonstrate an anti-obesity effect. In this research, long-term use of tamarind pulp water extract safety was evaluated. Tamarind pulp was extracted by reflux method, followed by freeze-drying to obtain dry ex...

  • Article
  • Open Access
40 Citations
10,206 Views
16 Pages

Anticancer Dose Adjustment for Patients with Renal and Hepatic Dysfunction: From Scientific Evidence to Clinical Application

  • Tomi Hendrayana,
  • André Wilmer,
  • Verena Kurth,
  • Ingo GH Schmidt-Wolf and
  • Ulrich Jaehde

27 February 2017

Most anticancer agents exhibit a narrow therapeutic index, i.e., a small change in plasma concentrations can lead to a less efficacious treatment or an unacceptable degree of toxicity. This study aimed at providing health professionals with a feasibl...

  • Article
  • Open Access
6 Citations
4,519 Views
4 Pages

17 February 2017

Rhaphidophora pinnata is suggested to prevent or treat cancer of genetic mutations. In this study, antimutagenic activity of an ethanol extract of Rhaphidophora pinnata leaves was evaluated by using a bone marrow micronucleus assay on mice. Male mice...

  • Article
  • Open Access
33 Citations
10,607 Views
8 Pages

16 February 2017

The combination of amoxicillin and enrofloxacin is a well-known mixture of veterinary drugs; it is used for the treatment of Gram-positive and Gram-negative bacteria. In the scientific literature, there is no high-performance liquid chromatography (H...

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Sci. Pharm. - ISSN 2218-0532