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Diseases, Volume 10, Issue 3

2022 September - 31 articles

Cover Story: Due to the complexity of the pathogenesis of sarcopenia, it is of great significance to identify nutritional biomarkers that could contribute to the prediction and monitoring of this condition. Therefore, this narrative review aims to define a set of biomarkers associated with nutrition and sarcopenia. First of all, higher levels of serum uric acid are related to better muscle function and, thus, may slow the progression of sarcopenia. Vitamin D status acts as a useful biomarker for predicting total mortality, hip fractures, and the development of sarcopenia. Additionally, there is an important focus on dietary antioxidants and their effects on muscle tissue. In conclusion, many nutritional biomarkers were found to be associated with sarcopenia and can therefore be used as prognostic indexes and risk factors. View this paper
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Articles (31)

  • Essay
  • Open Access
20 Citations
4,760 Views
14 Pages

The Promotion and Development of One Health at Swiss TPH and Its Greater Potential

  • Jakob Zinsstag,
  • Karin Hediger,
  • Yahya Maidane Osman,
  • Said Abukhattab,
  • Lisa Crump,
  • Andrea Kaiser-Grolimund,
  • Stephanie Mauti,
  • Ayman Ahmed,
  • Jan Hattendorf and
  • Kristina Pelikan
  • + 7 authors

14 September 2022

One Health, an integrated health concept, is now an integral part of health research and development. One Health overlaps with other integrated approaches to health such as EcoHealth or Planetary Health, which not only consider the patient or populat...

  • Article
  • Open Access
10 Citations
4,232 Views
16 Pages

Mediterranean Diet, a Posteriori Dietary Patterns, Time-Related Meal Patterns and Adiposity: Results from a Cross-Sectional Study in University Students

  • Paraskevi Detopoulou,
  • Vassilis Dedes,
  • Dimitra Syka,
  • Konstantinos Tzirogiannis and
  • Georgios I. Panoutsopoulos

11 September 2022

The transition to university is connected to potentially obesogenic dietary changes. Our aim was to assess the relation of Mediterranean diet adherence, and a posteriori dietary and meal patterns with adiposity in Greek students at the University of...

  • Article
  • Open Access
3 Citations
2,864 Views
19 Pages

Savings Groups for Social Health Protection: A Social Resilience Study in Rural Tanzania

  • Brigit Obrist,
  • Angel Dillip,
  • Albino Kalolo,
  • Iddy M. Mayumana,
  • Melina Rutishauser and
  • Vendelin T. Simon

9 September 2022

Global health experts use a health system perspective for research on social health protection. This article argues for a complementary actor perspective, informed by the social resilience framework. It presents a Saving4Health initiative with women...

  • Case Report
  • Open Access
7 Citations
14,746 Views
8 Pages

Oral Health Status and Multiple Sclerosis: Classic and Non-Classic Manifestations—Case Report

  • Céu Costa,
  • Hugo Santiago,
  • Sofia Pereira,
  • Ana Rita Castro and
  • Sandra Clara Soares

9 September 2022

Background: Multiple sclerosis is an autoimmune disease of the central nervous system with neurological and motor symptoms that affect the orofacial region. The aim of this work is to present a patient that lacks the three classic orofacial manifesta...

  • Article
  • Open Access
1 Citations
3,446 Views
13 Pages

A Case Series of Gastric Metastatic Growths

  • Mustafa Gandhi,
  • Harleen Kaur Chela,
  • Hamza Ertugrul,
  • Alhareth Al Juboori,
  • Karthik Gangu,
  • Deepthi Rao and
  • Ebubekir Daglilar

7 September 2022

Gastric cancer is one of the gastrointestinal malignancies that can be quite devastating with high morbidity and mortality. Unfortunately, it is a malignancy that is encountered all across the world and is often brought into suspicion based on sympto...

  • Review
  • Open Access
51 Citations
17,898 Views
40 Pages

Emerging Trends in Immunotherapy for Cancer

  • Alok K. Mishra,
  • Amjad Ali,
  • Shubham Dutta,
  • Shahid Banday and
  • Sunil K. Malonia

6 September 2022

Recent advances in cancer immunology have enabled the discovery of promising immunotherapies for various malignancies that have shifted the cancer treatment paradigm. The innovative research and clinical advancements of immunotherapy approaches have...

  • Perspective
  • Open Access
3 Citations
4,700 Views
10 Pages

30 August 2022

Sudden Infant Death Syndrome (SIDS) occurs unexpectedly in an otherwise healthy infant with no identifiable cause of death following a thorough investigation. A general hypervolemic state has been identified in SIDS, and fluid in the lungs suggests t...

  • Review
  • Open Access
22 Citations
6,950 Views
22 Pages

The Menace of Candida auris Epidemic Amidst the COVID-19 Pandemic: A Systematic Review

  • Hala Najeeb,
  • Sarush Ahmed Siddiqui,
  • Zahra Anas,
  • Syed Hasan Ali,
  • Shajie Ur Rehman Usmani,
  • Fareeha Jawed and
  • Hafsa Nazir Jatoi

29 August 2022

Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2), the causative agent for the Coronavirus Disease 2019 (COVID-19) pandemic, has sparked a medical emergency worldwide. With the rise in COVID-19 infections and an eventual increase in hospit...

  • Review
  • Open Access
17 Citations
4,594 Views
9 Pages

Gastric Cancer Due to Chronic H. pylori Infection: What We Know and Where We Are Going

  • Patrick Joseph Tempera,
  • Mark Michael,
  • Omar Tageldin and
  • Stephen Hasak

25 August 2022

Helicobacter pylori is an established cause of many gastrointestinal pathologies including peptic ulcer disease, gastritis, and gastric cancer. It is an entity that affects the global population, and its true nature has only been known since the 1980...

  • Article
  • Open Access
15 Citations
4,478 Views
11 Pages

Determinants of Post-COVID-19 Conditions among SARS-CoV-2-Infected Patients in Saudi Arabia: A Web-Based Cross-Sectional Study

  • Mohammed Samannodi,
  • Hassan Alwafi,
  • Abdallah Y. Naser,
  • Abdullah A. Al Qurashi,
  • Jumanah T. Qedair,
  • Emad Salawati,
  • Mohammed A. Almatrafi,
  • Rakan Ekram,
  • Rahaf I. Bukhari and
  • Faisal Minshawi
  • + 5 authors

23 August 2022

Background: Large numbers of people infected with COVID-19 developed acute symptoms. Post-COVID-19 conditions have been reported after recovery or discharge from the hospital. However, little is known about the prevalence and possible risk factors of...

  • Article
  • Open Access
15 Citations
3,763 Views
10 Pages

A Deep Learning Methodology for the Detection of Abnormal Parathyroid Glands via Scintigraphy with 99mTc-Sestamibi

  • Ioannis D. Apostolopoulos,
  • Nikolaos D. Papathanasiou and
  • Dimitris J. Apostolopoulos

23 August 2022

Background: Parathyroid proliferative disorder encompasses a wide spectrum of diseases, including parathyroid adenoma (PTA), parathyroid hyperplasia, and parathyroid carcinoma. Imaging modalities that deliver their results preoperatively help in the...

  • Case Report
  • Open Access
1 Citations
3,946 Views
14 Pages

Hemophagocytic Lymphohistiocytosis in the Setting of Therapy-Induced Acute Myeloid Leukemia: An Autopsy Report

  • Hisham F. Bahmad,
  • Samantha Gogola,
  • Mohamad K. Elajami,
  • Carole Brathwaite,
  • Amilcar A. Castellano-Sánchez,
  • Vathany Sriganeshan and
  • Yumna Omarzai

19 August 2022

Hemophagocytic lymphohistiocytosis (HLH) is a life-threatening hyper-inflammatory disorder that occurs due to immunologic dysregulation. HLH can be primary (hereditary) or secondary to infections, autoimmune diseases, immune deficiencies, metabolic d...

  • Review
  • Open Access
21 Citations
4,240 Views
13 Pages

Acute Kidney Injury in COVID-19 Patients: Pathogenesis, Clinical Characteristics, Therapy, and Mortality

  • Venice Chávez-Valencia,
  • Citlalli Orizaga-de-la-Cruz and
  • Francisco Alejandro Lagunas-Rangel

19 August 2022

Coronavirus disease 2019 (COVID-19) is a disease caused by infection with the SARS-CoV-2 virus and has represented one of the greatest challenges humanity has faced in recent years. The virus can infect a large number of organs, including the lungs a...

  • Article
  • Open Access
12 Citations
3,817 Views
16 Pages

Effective Combination Immunotherapy with Oncolytic Adenovirus and Anti-PD-1 for Treatment of Human and Murine Ovarian Cancers

  • Camilla Heiniö,
  • James Clubb,
  • Tatiana Kudling,
  • Dafne Quixabeira,
  • Victor Cervera-Carrascon,
  • Riikka Havunen,
  • Susanna Grönberg-Vähä-Koskela,
  • João Manuel Santos,
  • Johanna Tapper and
  • Akseli Hemminki
  • + 1 author

8 August 2022

Ovarian cancer (OvCa) is one of the most common gynecological cancers and has the highest mortality in this category. Tumors are often detected late, and unfortunately over 70% of OvCa patients experience relapse after first-line treatments. OvCa has...

  • Article
  • Open Access
3 Citations
3,563 Views
16 Pages

Time to Death and Associated Factors among Tuberculosis Patients in South West Ethiopia: Application of Shared Frailty Model

  • Yasin Negash Jabir,
  • Tafere Tilahun Aniley,
  • Reta Habtamu Bacha,
  • Legesse Kassa Debusho,
  • Teshita Uke Chikako,
  • John Elvis Hagan,
  • Abdul-Aziz Seidu and
  • Bright Opoku Ahinkorah

5 August 2022

(1) Background: Tuberculosis is a bacterial disease mainly caused by Mycobacterium tuberculosis. It is one of the major public health problems in the world and now ranks alongside human immunodeficiency virus (HIV) as the leading infectious cause of...

  • Article
  • Open Access
12 Citations
3,210 Views
11 Pages

3 August 2022

(1) Background: Nursing is a satisfying employment pathway, as nurses preserve lives, but it is also considered one of the most stressful care professions. Nursing is a lifesaving and highly satisfying profession, yet it is considered one of the most...

  • Brief Report
  • Open Access
9 Citations
3,379 Views
8 Pages

T-Cell Assay after COVID-19 Vaccination Could Be a Useful Tool? A Pilot Study on Interferon-Gamma Release Assay in Healthcare Workers

  • Silva Seraceni,
  • Elena Zocca,
  • Tamara Emanuela Cervone,
  • Flaminia Tomassetti,
  • Isabella Polidori,
  • Massimiliano Valisi,
  • Francesco Broccolo,
  • Graziella Calugi,
  • Sergio Bernardini and
  • Massimo Pieri

Background: SARS-CoV-2 T-cells are crucial for long-term protection against reinfection. The aim was to demonstrate the Interferon-gamma Release Assay (IGRA) test could be useful for vaccination monitoring. Methods: In a prospective cohort of 98 vacc...

  • Article
  • Open Access
6 Citations
7,647 Views
10 Pages

The Effects of Use of Long-Term Second-Generation Antipsychotics on Liver and Kidney Function: A Prospective Study

  • Evangelia Papatriantafyllou,
  • Dimitris Efthymiou,
  • Maria Markopoulou,
  • Efthymia-Maria Sakellariou and
  • Emilia Vassilopoulou

(1) Background: The second-generation antipsychotics (SGAPs) induce metabolic and inflammatory side effects, but documentation of their effects on the liver and kidneys is scarce. Aim: To study the three-year fluctuation of selected markers of renal...

  • Article
  • Open Access
3 Citations
4,103 Views
14 Pages

Unmet Nutritional and Psychological Needs of Cancer Patients: An Integrated Multi-Professional Model Approach

  • Giuseppe Carruba,
  • Maria Luisa Calagna,
  • Ildegarda Campisi,
  • Stella Cutrera,
  • Laura Napoli,
  • Giovanni Pitti,
  • Valentina Palmisano,
  • Giuseppina Savio,
  • Antonella Usset and
  • Livio Blasi
  • + 3 authors

This paper presents a multi-professional integrated approach toward the recognition and management of the nutritional and psychological needs of cancer patients. In particular, the patients undertook a multi-professional, multistep process that inclu...

  • Article
  • Open Access
3 Citations
4,217 Views
17 Pages

The meningococcal disease is a global health threat, but is preventable through vaccination. Adjuvants improve meningococcal vaccines and are able to trigger different aspects of the immune response. The present work evaluated the immune response of...

  • Review
  • Open Access
9 Citations
6,002 Views
14 Pages

Gastrointestinal Tract Microbiome Effect and Role in Disease Development

  • Neira Crnčević,
  • Mirsada Hukić,
  • Sara Deumić,
  • Amir Selimagić,
  • Ada Dozić,
  • Ismet Gavrankapetanović,
  • Dženana Klepo and
  • Monia Avdić

In recent years, it has been shown that gastrointestinal microflora has a substantial impact on the development of a large number of chronic diseases. The imbalance in the number or type of microbes in the gastrointestinal tract can lead to diseases...

  • Review
  • Open Access
15 Citations
5,596 Views
16 Pages

The 8th Wonder of the Cancer World: Esophageal Cancer and Inflammation

  • Harleen Kaur Chela,
  • Karthik Gangu,
  • Hamza Ertugrul,
  • Alhareth Al Juboori,
  • Ebubekir Daglilar and
  • Veysel Tahan

Esophageal cancer is a devastating malignancy which can be detected at an early stage but is more often diagnosed as an advanced process. It affects both men and women and inflicts the young and the elderly. There are multiple underlying factors invo...

  • Article
  • Open Access
11 Citations
3,529 Views
11 Pages

Clinical Application of the Food Compass Score: Positive Association to Mediterranean Diet Score, Health Star Rating System and an Early Eating Pattern in University Students

  • Paraskevi Detopoulou,
  • Dimitra Syka,
  • Konstantina Koumi,
  • Vasileios Dedes,
  • Konstantinos Tzirogiannis and
  • Georgios I. Panoutsopoulos

Nutrient profiling systems (NPS) assist consumers in food choices. Several scores based on NPS have been proposed, but data on their clinical application are lacking. The food compass score (FCS) is a newly developed NPS per 100 kcal (from 1 “l...

  • Review
  • Open Access
36 Citations
7,703 Views
13 Pages

Nutritional and Nutrition-Related Biomarkers as Prognostic Factors of Sarcopenia, and Their Role in Disease Progression

  • Sousana K. Papadopoulou,
  • Gavriela Voulgaridou,
  • Foivi S. Kondyli,
  • Mariella Drakaki,
  • Kyriaki Sianidou,
  • Rozalia Andrianopoulou,
  • Nikolaos Rodopaios and
  • Agathi Pritsa

Due to the multifactorial pathogenesis of sarcopenia, it is crucial to identify biomarkers that are risk factors for sarcopenia, and which therefore have a prognostic function. Aim: This narrative review aims to define a set of biomarkers associated...

  • Review
  • Open Access
18 Citations
5,751 Views
15 Pages

Introduction: Chimeric antigen receptor T-cell (CAR-T) therapy is an innovative therapeutic option for addressing certain recurrent or refractory hematological malignancies. However, CAR-T cells also cause the release of pro-inflammatory cytokines th...

  • Article
  • Open Access
4 Citations
3,091 Views
10 Pages

Are We Identifying Malnutrition in Hospitalized Patients with Hematologic Malignancies? Results from a Quality Clinical Audit

  • Eftychia Kanioura,
  • Ioannis-Georgios Tzanninis,
  • Kalliopi-Anna Poulia,
  • Aliki Stamou,
  • Athanasios Liaskas,
  • Dimitrios Politis,
  • Athina Kaoura,
  • Georgios Garefalakis,
  • Nora Athina Viniou and
  • Panagiotis Diamantopoulos

Disease-related malnutrition (DRM) is highly prevalent among patients with hematologic malignancies. The aim of the present study was to evaluate the prevalence of DRM in hospitalized patients with hematologic malignancies and investigate the level o...

  • Article
  • Open Access
9 Citations
3,535 Views
14 Pages

Plasma Nickel Levels Correlate with Low Muscular Strength and Renal Function Parameters in Patients with Prostate Cancer

  • Antoni Alegre-Martínez,
  • María Isabel Martínez-Martínez,
  • José Rubio-Briones and
  • Omar Cauli

Nickel is associated with cancer in occupational exposure. However, few studies have been devoted to analyzing the effects of nickel at environmental concentrations in cancer patients. In this work, the concentration of nickel in blood samples from p...

  • Article
  • Open Access
14 Citations
3,954 Views
11 Pages

Predicting the Spread of SARS-CoV-2 in Italian Regions: The Calabria Case Study, February 2020–March 2022

  • Francesco Branda,
  • Ludovico Abenavoli,
  • Massimo Pierini and
  • Sandra Mazzoli

Despite the stunning speed with which highly effective and safe vaccines have been developed, the emergence of new variants of SARS-CoV-2 causes high rates of (re)infection, a major impact on health care services, and a slowdown to the socio-economic...

  • Review
  • Open Access
84 Citations
10,111 Views
16 Pages

Quercetin belongs to the broader category of polyphenols. It is found, in particular, among the flavonols, and along with kaempferol, myricetin and isorhamnetin, it is recognized as a foreign substance after ingestion in contrast to vitamins. Quercet...

  • Review
  • Open Access
3,126 Views
6 Pages

Hypersensitivity pneumonitis (HP) is a consequence of immune-mediated reactions caused by recurrent exposure to environmental agents. Recently, clinical practice guidelines for the diagnosis of HP were published and increased interest in HP. On the o...

  • Review
  • Open Access
59 Citations
11,253 Views
25 Pages

Inflammation and Gastric Cancer

  • Aunchalee Jaroenlapnopparat,
  • Khushboo Bhatia and
  • Sahin Coban

Gastric cancer remains a major killer globally, although its incidence has declined over the past century. It is the fifth most common cancer and the third most common reason for cancer-related deaths worldwide. Gastric cancer is the outcome of a com...

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Diseases - ISSN 2079-9721