You are currently viewing a new version of our website. To view the old version click .

Biology, Volume 9, Issue 5

May 2020 - 24 articles

Cover Story: 5-FU-based chemotherapy remains the mainstay for colorectal cancer (CRC) treatment. However, cancer cells acquire chemoresistance, causing treatment failure. Understanding the molecular mechanism of resistance will uncover new avenues for curing CRC. One mechanism of acquired chemoresistance is defective drug metabolism. 5-FU is converted into various metabolites, causing DNA and RNA damage and inducing apoptosis. An HRMS-based method was used to extract and quantify levels of 5-FU metabolites from parental and resistant CRC cell lysates and media. Results show the reduced levels of 5-FU metabolites in resistant cells. Moreover, treatment of CRC cells with FdUMP, an active metabolite of 5-FU, induced resistant cell death. Overall, an effective and efficient protocol was developed for the comparative quantitation of polar compounds from cells. FdUMP is also highlighted as an alternative CRC therapy. View this paper.
  • Issues are regarded as officially published after their release is announced to the table of contents alert mailing list .
  • You may sign up for email alerts to receive table of contents of newly released issues.
  • PDF is the official format for papers published in both, html and pdf forms. To view the papers in pdf format, click on the "PDF Full-text" link, and use the free Adobe Reader to open them.

Articles (24)

  • Article
  • Open Access
7 Citations
3,587 Views
18 Pages

A New IL6 Isoform in Chinese Soft-Shelled Turtle (Pelodiscus sinesis) Discovered: Its Regulation during Cold Stress and Infection

  • Zuobing Zhang,
  • Miao Tian,
  • Ruxin Song,
  • Xiao Xing,
  • Yong Fan,
  • Lan Wang,
  • Cuijuan Niu and
  • Roy A. Dalmo

25 May 2020

The Chinese soft-shelled turtle (Pelodiscus sinesis) is a widely cultured commercial species in East and Southeast Asian countries. The turtles frequently suffer from acute cold stress during farming in China. Stress-induced factor such as Interleuki...

  • Article
  • Open Access
13 Citations
5,472 Views
15 Pages

22 May 2020

Marine microalgae are photosynthetic microorganisms at the base of the marine food webs. They are characterized by huge taxonomic and metabolic diversity and several species have been shown to have bioactivities useful for the treatment of human path...

  • Article
  • Open Access
142 Citations
5,140 Views
14 Pages

21 May 2020

In this study, we investigate the infection system of the novel coronavirus (2019-nCoV) with a nonlocal operator defined in the Caputo sense. With the help of the fractional natural decomposition method (FNDM), which is based on the Adomian decomposi...

  • Review
  • Open Access
46 Citations
7,261 Views
17 Pages

Clinical Genetics of Prolidase Deficiency: An Updated Review

  • Marta Spodenkiewicz,
  • Michel Spodenkiewicz,
  • Maureen Cleary,
  • Marie Massier,
  • Giorgos Fitsialos,
  • Vincent Cottin,
  • Guillaume Jouret,
  • Céline Poirsier,
  • Martine Doco-Fenzy and
  • Anne-Sophie Lèbre

21 May 2020

Prolidase is a ubiquitous enzyme that plays a major role in the metabolism of proline-rich proteins. Prolidase deficiency is a rare autosomal recessive inborn metabolic and multisystemic disease, characterized by a protean association of symptoms, na...

  • Review
  • Open Access
10 Citations
4,729 Views
14 Pages

21 May 2020

Blue gourami belongs to the Labyrinithici fish and the Anabantiform order. It is characterized by a specific organ located above its gills for the respiration of atmospheric oxygen. This specific adaptation to low oxygen levels affects reproduction t...

  • Article
  • Open Access
4 Citations
3,384 Views
12 Pages

Period of Boar Ejaculate Collection Contributes to the Yearly Intra-Male Variability of Seminal Plasma Cytokines

  • Lorena Padilla,
  • Xiomara Lucas,
  • Inmaculada Parrilla,
  • Cristina Perez-Patiño,
  • Heriberto Rodriguez-Martinez,
  • Jordi Roca and
  • Isabel Barranco

20 May 2020

The concentrations of cytokines in seminal plasma (SP) fluctuate over time in healthy males, weakening their practical usefulness as diagnostic tools. This study evaluated the relevance of intra-male variability in SP cytokines and to what extent the...

  • Article
  • Open Access
5 Citations
4,275 Views
10 Pages

Evolution of Hemoglobin Genes in a Subterranean Rodent Species (Lasiopodomys mandarinus)

  • Hong Sun,
  • Kaihong Ye,
  • Denghui Liu,
  • Dan Pan,
  • Shiming Gu and
  • Zhenlong Wang

20 May 2020

The Mandarin vole (Lasiopodomys mandarinus), a typical subterranean rodent, has undergone hematological adaptations to tolerate the hypoxic/hypercapnic underground environment. Hemoglobin (Hb) genes encode respiratory proteins functioning principally...

  • Review
  • Open Access
44 Citations
8,882 Views
21 Pages

Magnetotactic Bacteria and Magnetosomes as Smart Drug Delivery Systems: A New Weapon on the Battlefield with Cancer?

  • Danuta Kuzajewska,
  • Agata Wszołek,
  • Wojciech Żwierełło,
  • Lucyna Kirczuk and
  • Agnieszka Maruszewska

19 May 2020

An important direction of research in increasing the effectiveness of cancer therapies is the design of effective drug distribution systems in the body. The development of the new strategies is primarily aimed at improving the stability of the drug a...

  • Review
  • Open Access
145 Citations
30,465 Views
13 Pages

19 May 2020

Parkinson’s disease (PD) is a multi-attribute neurodegenerative disorder combining motor and nonmotor symptoms without well-defined diagnostic clinical markers. The presence of primary motor features (bradykinesia, rest tremor, rigidity and los...

  • Article
  • Open Access
4 Citations
3,868 Views
14 Pages

The Utility of Genomic and Transcriptomic Data in the Construction of Proxy Protein Sequence Databases for Unsequenced Tree Nuts

  • Cary Pirone-Davies,
  • Melinda A. McFarland,
  • Christine H. Parker,
  • Yoko Adachi and
  • Timothy R. Croley

19 May 2020

As the apparent incidence of tree nut allergies rises, the development of MS methods that accurately identify tree nuts in food is critical. However, analyses are limited by few available tree nut protein sequences. We assess the utility of translate...

of 3

Get Alerted

Add your email address to receive forthcoming issues of this journal.

XFacebookLinkedIn
Biology - ISSN 2079-7737