Table of Contents
Antibiotics, Volume 9, Issue 2 (February 2020) – 59 articles
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Cover Story (view full-size image) Staphylococcus aureus poses a significant and enduring challenge to both human and veterinary [...] Read more. Staphylococcus aureus poses a significant and enduring challenge to both human and veterinary medicine. This challenge is exacerbated by the spread of antimicrobial-resistant strains, of particular note being methicillin-resistant S. aureus (MRSA). As a result, much effort is focussing on the development of alternative therapeutic approaches. One option being investigated is the exploitation of bacterocins and other inhibitory products made by the competing microflora. In our review, we present the current status of research investigating staphylococcal-produced bacteriocins and antimicrobial peptides as alternative treatments for S. aureus infections. A few show promising activity, including efficacy in animal models, but much work remains to be done if we are to fully explore and exploit this potentially useful source of new antimicrobials. View this paper