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Open AccessConcept Paper

Critical Parameters for the Development of Novel Therapies for Severe and Resistant Infections—A Case Study on CAL02, a Non-Traditional Broad-Spectrum Anti-Virulence Drug

1
Combioxin SA, 8 rue de la Rôtisserie, 1204 Geneva, Switzerland
2
Pulmonary and Critical Care Medicine, Medstar Washington Hospital Center, Washington, DC 20010, USA
*
Author to whom correspondence should be addressed.
Antibiotics 2020, 9(2), 94; https://doi.org/10.3390/antibiotics9020094
Received: 23 January 2020 / Revised: 16 February 2020 / Accepted: 17 February 2020 / Published: 21 February 2020
(This article belongs to the Special Issue Nontraditional Antibiotics—Challenges and Triumphs)
Background: Poor outcomes in severe and resistant infections, together with the economic struggles of companies active in the field of anti-infective development, call for new solutions and front runners with novel approaches. Among “non-traditional” approaches, blocking virulence could be a game changer. Objectives: This review offers a perspective on parameters that have determined the development path of CAL02, a novel anti-virulence agent, with a view to steering clear of the obstacles and limitations that impede market sustainability for new anti-infective drugs. Conclusions and implications of key findings: This case study highlights four pillars that may support the development of other non-traditional drugs and, concurrently, provide a new model that could reshape the field. Therapeutic triggers, study designs, and economic parameters are discussed. View Full-Text
Keywords: severe infections; pneumonia; virulence; broad-spectrum; nontraditional; toxins; endpoint severe infections; pneumonia; virulence; broad-spectrum; nontraditional; toxins; endpoint
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MDPI and ACS Style

Azeredo da Silveira, S.; Shorr, A.F. Critical Parameters for the Development of Novel Therapies for Severe and Resistant Infections—A Case Study on CAL02, a Non-Traditional Broad-Spectrum Anti-Virulence Drug. Antibiotics 2020, 9, 94.

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