Antibiotics, Volume 8, Issue 4 (December 2019) – 115 articles
Cover Story (view full-size image): The spread of resistance and the outer membrane of Gram-negative bacteria, which functions as a barrier, both preclude the clinical use of many antibiotics for treating infections. Recent work has greatly strengthened our understanding of the molecular machines required for outer-membrane assembly. Now, considerable advances have been made in the discovery efforts for novel compounds targeting outer-membrane assembly. Clever strategies, both genetic and biochemical, have identified many promising compounds acting on the outer membrane. Potent new chemicals targeting evolutionarily conserved pathways are now being developed further for future clinical use. Hope for a novel class of outer-membrane-acting antibiotics is now the highest it has been in over forty years. View this paper
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