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Antibiotics, Volume 8, Issue 4

December 2019 - 115 articles

Cover Story: The spread of resistance and the outer membrane of Gram-negative bacteria, which functions as a barrier, both preclude the clinical use of many antibiotics for treating infections. Recent work has greatly strengthened our understanding of the molecular machines required for outer-membrane assembly. Now, considerable advances have been made in the discovery efforts for novel compounds targeting outer-membrane assembly. Clever strategies, both genetic and biochemical, have identified many promising compounds acting on the outer membrane. Potent new chemicals targeting evolutionarily conserved pathways are now being developed further for future clinical use. Hope for a novel class of outer-membrane-acting antibiotics is now the highest it has been in over forty years. View this paper
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Articles (115)

  • Communication
  • Open Access
49 Citations
7,811 Views
18 Pages

Background: The emergence of multidrug-resistant organisms (MDROs) is a global public health issue, severely hindering clinicians in administering appropriate antimicrobial therapy. Drug repurposing is a drug development strategy, during which new ph...

  • Concept Paper
  • Open Access
43 Citations
28,987 Views
20 Pages

Chronic Lyme Disease: An Evidence-Based Definition by the ILADS Working Group

  • Samuel Shor,
  • Christine Green,
  • Beatrice Szantyr,
  • Steven Phillips,
  • Kenneth Liegner,
  • Joseph Jr. Burrascano,
  • Robert Bransfield and
  • Elizabeth L. Maloney

Objective: Chronic Lyme disease has been a poorly defined term and often dismissed as a fictitious entity. In this paper, the International Lyme and Associated Diseases Society (ILADS) provides its evidence-based definition of chronic Lyme disease. D...

  • Article
  • Open Access
7 Citations
5,015 Views
13 Pages

Development, Validation, and Stability Assessment Application of RP-HPLC-DAD Method for Quantification of Ampicillin in Total Parenteral Nutrition Admixtures

  • Maciej Stawny,
  • Aleksandra Gostyńska,
  • Katarzyna Dettlaff,
  • Anna Jelińska,
  • Marta Kościelniak and
  • Magdalena Ogrodowczyk

Background: The administration of total parenteral nutrition (TPN) is a common procedure in intensive care units, where the concomitant use of other intravenous medication is frequently needed. One of the particularly dangerous complications for neur...

  • Communication
  • Open Access
9 Citations
8,983 Views
9 Pages

Exclusive Production of Gentamicin C1a from Micromonospora purpurea by Metabolic Engineering

  • Zeng Wei,
  • Xianai Shi,
  • Rong Lian,
  • Weibin Wang,
  • Wenrong Hong and
  • Shaobin Guo

Gentamicin C1a is an important precursor to the synthesis of etimicin, a potent antibiotic. Wild type Micromonospora purpurea Gb1008 produces gentamicin C1a, besides four other gentamicin C components: C1, C2, C2a, and C2b. While the previously repor...

  • Article
  • Open Access
92 Citations
8,310 Views
13 Pages

Short chain fatty acids (SCFAs) are commonly produced by healthy gut microbiota and they have a protective role against enteric pathogens. SCFAs also have direct antimicrobial activity against bacterial pathogens by diffusion across the bacterial mem...

  • Article
  • Open Access
20 Citations
5,270 Views
12 Pages

The Inc FII Plasmid and its Contribution in the Transmission of blaNDM-1 and blaKPC-2 in Klebsiella pneumoniae in Egypt

  • Eman Ramadan Mohamed,
  • Mamdouh Yones Ali,
  • Nancy G F M Waly,
  • Hamada Mohamed Halby and
  • Rehab Mahmoud Abd El-Baky

The emergence of blaKPC-2 and blaNDM-1 producing Klebsiella pneumoniae represents a great problem in many Egyptian hospitals. One hundred and twenty-six K. pneumoniae isolates from patients admitted to Assiut University Hospital were identified by an...

  • Article
  • Open Access
17 Citations
8,416 Views
11 Pages

Factors Influencing the Onset of Intra- and Post- Operative Complications Following Tooth Exodontia: Retrospective Survey on 1701 Patients

  • Erica Vettori,
  • Fulvia Costantinides,
  • Vanessa Nicolin,
  • Roberto Rizzo,
  • Giuseppe Perinetti,
  • Michele Maglione and
  • Roberto Di Lenarda

Complications after tooth extraction may occur because of several factors correlated to the patient’s medical history, surgical site or type of intervention. The aim of this retrospective cohort study was to evaluate type and frequency of compl...

  • Article
  • Open Access
7 Citations
5,817 Views
9 Pages

Tracing Penicillin Movement in Citrus Plants Using Fluorescence-Labeled Penicillin

  • Nabil Killiny,
  • Pedro Gonzalez-Blanco,
  • Yulica Santos-Ortega,
  • Fuad Al-Rimawi,
  • Amit Levy,
  • Faraj Hijaz,
  • Ute Albrecht and
  • Ozgur Batuman

Huánglóngbìng (HLB), citrus greening, is one of the most destructive diseases of citrus plants worldwide. In North America, HLB is caused by the phloem-limited bacterium Candidatus Liberibacter asiaticus and is transmitted by the...

  • Review
  • Open Access
39 Citations
8,854 Views
14 Pages

The scope of antimicrobial stewardship (AMS) surveys on community pharmacists (CPs) is uncertain. This study examines the breadth and quality of AMS survey tools measuring the stewardship knowledge, perceptions and practices (KPP) of CPs and analyse...

  • Review
  • Open Access
54 Citations
6,547 Views
12 Pages

The Use of Nanomedicine for Targeted Therapy against Bacterial Infections

  • Abdulkader Masri,
  • Ayaz Anwar,
  • Naveed Ahmed Khan and
  • Ruqaiyyah Siddiqui

The emergence of drug resistance combined with limited success in the discovery of newer and effective antimicrobial chemotherapeutics poses a significant challenge to human and animal health. Nanoparticles may be an approach for effective drug devel...

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Antibiotics - ISSN 2079-6382