The Use of Nanomedicine for Targeted Therapy against Bacterial Infections
1
Department of Biological Sciences, School of Science and Technology, Sunway University, Selangor 47500, Malaysia
2
Department of Biology, Chemistry and Environmental Sciences, College of Arts and Sciences, American University of Sharjah, University City, Sharjah 26666, UAE
*
Author to whom correspondence should be addressed.
†
These authors contributed equally to this work.
Antibiotics 2019, 8(4), 260; https://doi.org/10.3390/antibiotics8040260
Received: 9 August 2019 / Revised: 16 October 2019 / Accepted: 22 October 2019 / Published: 11 December 2019
(This article belongs to the Special Issue Novel Strategies against Pathogenic Bacteria)
The emergence of drug resistance combined with limited success in the discovery of newer and effective antimicrobial chemotherapeutics poses a significant challenge to human and animal health. Nanoparticles may be an approach for effective drug development and delivery against infections caused by multi-drug resistant bacteria. Here we discuss nanoparticles therapeutics and nano-drug delivery against bacterial infections. The therapeutic efficacy of numerous kinds of nanoparticles including nanoantibiotics conjugates, small molecules capped nanoparticles, polymers stabilized nanoparticles, and biomolecules functionalized nanoparticles has been discussed. Moreover, nanoparticles-based drug delivery systems against bacterial infections have been described. Furthermore, the fundamental limitation of biocompatibility and biosafety of nanoparticles is also conferred. Finally, we propose potential future strategies of nanomaterials as antibacterials.
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Keywords:
nanomedicine; antibacterial efficacy; drug delivery
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited
MDPI and ACS Style
Masri, A.; Anwar, A.; Khan, N.A.; Siddiqui, R. The Use of Nanomedicine for Targeted Therapy against Bacterial Infections. Antibiotics 2019, 8, 260. https://doi.org/10.3390/antibiotics8040260
AMA Style
Masri A, Anwar A, Khan NA, Siddiqui R. The Use of Nanomedicine for Targeted Therapy against Bacterial Infections. Antibiotics. 2019; 8(4):260. https://doi.org/10.3390/antibiotics8040260
Chicago/Turabian StyleMasri, Abdulkader; Anwar, Ayaz; Khan, Naveed A.; Siddiqui, Ruqaiyyah. 2019. "The Use of Nanomedicine for Targeted Therapy against Bacterial Infections" Antibiotics 8, no. 4: 260. https://doi.org/10.3390/antibiotics8040260
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