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Antibiotics, Volume 14, Issue 2

February 2025 - 104 articles

Cover Story: Streptococcus agalactiae (GBS) is a leading cause of neonatal sepsis, with globally rising resistance rates. Broth microdilution (BMD) is the gold standard for antimicrobial susceptibility testing (AST); however, it is unsuitable for large-scale studies, where solid agar dilution is more practical. We compared AST results from BMD and agar dilution for benzylpenicillin, chloramphenicol, clindamycin, erythromycin, gentamicin, levofloxacin, tetracycline, and vancomycin. Using a panel of 24 well-characterised susceptible and resistant GBS strains, we found strong correlations for most antibiotics. Cohen’s kappa values (0.88–1.00) indicated excellent agreement in resistance determination. We show that agar dilution is a valid method for high-throughput AMR surveillance and a critical tool for identifying emerging GBS resistance trends. View this paper
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Articles (104)

  • Article
  • Open Access
2 Citations
2,966 Views
16 Pages
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Factors Influencing Antibiotic Prescribing and Antibiotic Resistance Awareness Among Primary Care Physicians in Poland

  • Karolina Świder,
  • Mateusz Babicki,
  • Aleksander Biesiada,
  • Monika Suszko,
  • Agnieszka Mastalerz-Migas and
  • Karolina Kłoda
Antibiotics2025, 14(2), 212;https://doi.org/10.3390/antibiotics14020212

19 February 2025

Introduction: Antibiotic resistance is a major public health problem in Europe. Most antibiotics are sold only by prescription in Poland, and it is mainly up to physicians to decide whether to start antibiotic treatment. Therefore, we analyzed the fa...

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  • Article
  • Open Access
1,369 Views
12 Pages
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A Precision Medicine Model for Targeted Antibiotic Therapy in Urinary Tract Infections: A Valuable Tool to Reduce Hospitalization Stay and the Time to Switch to Oral Treatment

  • Tommaso Cai,
  • Anna Brugnolli,
  • Massimiliano Lanzafame,
  • Fabiana Dellai,
  • Carlo Tascini,
  • Claudio Scarparo,
  • Vito Racanelli,
  • Orietta Massidda,
  • Gernot Bonkat and
  • Luca Gallelli
  • + 1 author
Antibiotics2025, 14(2), 211;https://doi.org/10.3390/antibiotics14020211

19 February 2025

Background/Objectives: The management of urinary tract infections (UTIs) has become an increasingly challenging medical intervention. This study explores whether adoption of a precision medicine model could improve the management of acute uncomplicat...

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  • Article
  • Open Access
2 Citations
2,284 Views
11 Pages
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A National Surveillance of the Antibiotic Susceptibility of Acinetobacter baumannii in Saudi Arabia

  • Abrar K. Thabit,
  • Feras S. Alharbi,
  • Anas F. Jawah,
  • Ammar M. Alghamdi,
  • Musaab Y. Miaji,
  • Fatimah Alturki,
  • Nehal Hosin,
  • Mohammed Bazuqamah,
  • Masaad Saeed Almutairi and
  • Hamad Alhamed
  • + 6 authors
Antibiotics2025, 14(2), 209;https://doi.org/10.3390/antibiotics14020209

19 February 2025

Most surveillance studies in Saudi Arabia have been single-centered or did not use the gold standard broth microdilution (BMD) antimicrobial susceptibility test. This is the first study from Saudi Arabia to evaluate the resistance profiles of Acineto...

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  • Article
  • Open Access
1 Citations
1,976 Views
10 Pages
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Combating Metallo-β-Lactamase-Producing Pseudomonas aeruginosa: The Fractional Inhibitory Concentration Index as a Tool to Evaluate Antibiotic Synergy

  • Guido Granata,
  • Carolina Venditti,
  • Claudia Rotondo,
  • Valentina Dimartino,
  • Silvia D’Arezzo,
  • Assunta Gallo,
  • Gabriella Parisi,
  • Alessandro Capone,
  • Carla Fontana and
  • Stefania Cicalini
Antibiotics2025, 14(2), 210;https://doi.org/10.3390/antibiotics14020210

19 February 2025

Background: Multi-drug-resistant Gram-negative bacteria producing metallo-β-lactamase are an increasing concern. Here, we described three cases of infection due to difficult-to-treat and drug-resistant P. aeruginosa producing metallo-β-lact...

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  • Article
  • Open Access
2,221 Views
11 Pages
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Temporal Trends of Escherichia coli Antimicrobial Resistance and Antibiotic Utilization in Australian Long-Term Care Facilities

  • Chloé Corrie Hans Smit,
  • Caitlin Keighley,
  • Kris Rogers,
  • Spiros Miyakis,
  • Katja Taxis,
  • Hamish Robertson and
  • Lisa Gail Pont
Antibiotics2025, 14(2), 208;https://doi.org/10.3390/antibiotics14020208

18 February 2025

Background/Objectives: Antimicrobial resistance (AMR) is a global problem with antibiotic consumption considered a key modifiable factor for the development of AMR. Long-term care (LTC) facilities have been identified as potential reservoirs for Esch...

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  • Review
  • Open Access
40 Citations
6,065 Views
31 Pages
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Nanomaterial-Based Strategies to Combat Antibiotic Resistance: Mechanisms and Applications

  • Nargish Parvin,
  • Sang Woo Joo and
  • Tapas K. Mandal
Antibiotics2025, 14(2), 207;https://doi.org/10.3390/antibiotics14020207

18 February 2025

The rapid rise of antibiotic resistance has become a global health crisis, necessitating the development of innovative strategies to combat multidrug-resistant (MDR) pathogens. Nanomaterials have emerged as promising tools in this fight, offering uni...

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  • Article
  • Open Access
1 Citations
1,830 Views
18 Pages
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Genomic Insights into Colistin and Tigecycline Resistance in ESBL-Producing Escherichia coli and Klebsiella pneumoniae Harboring blaKPC Genes in Ecuador

  • David Ortega-Paredes,
  • Felipe Del Canto,
  • Rafael Rios,
  • Lorena Diaz,
  • Jinnethe Reyes,
  • Cesar A. Arias and
  • Jeannete Zurita
Antibiotics2025, 14(2), 206;https://doi.org/10.3390/antibiotics14020206

17 February 2025

Introduction: Escherichia coli (E. coli) and Klebsiella pneumoniae (K. pneumoniae) are resistant to third-generation cephalosporins (3GCs), carbapenems, colistin, and tigecycline, making them a major public health priority, mainly within the developi...

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  • Article
  • Open Access
1,742 Views
10 Pages
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Prognostic Value of C-Reactive Protein in Primary Total Hip Arthroplasty

  • Moritz Mederake,
  • Ulf Krister Hofmann and
  • Georgios Eleftherakis
Antibiotics2025, 14(2), 205;https://doi.org/10.3390/antibiotics14020205

16 February 2025

Background/Objectives: Periprosthetic joint infections (PJIs) are feared complications in arthroplasty and are associated with an increased mortality rate. PJI prevention is of paramount importance since treatment is difficult. In case of an infectio...

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  • Article
  • Open Access
1 Citations
1,281 Views
12 Pages
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Pharmacogenetics and Pharmacokinetics of Moxifloxacin in MDR-TB Patients in Indonesia: Analysis for ABCB1 and SLCO1B1

  • Nurul Annisa,
  • Nadiya N. Afifah,
  • Prayudi Santoso,
  • Vycke Yunivita,
  • Lindsey H. M. te Brake,
  • Rob E. Aarnoutse,
  • Melisa I. Barliana and
  • Rovina Ruslami
Antibiotics2025, 14(2), 204;https://doi.org/10.3390/antibiotics14020204

16 February 2025

Background/Objectives: Studies show that SNPs in ABCB1 rs2032582 and SLCO1B1 rs4149015 affect the PK profile of moxifloxacin, a key drug for MDR-TB. This study aimed to assess the genotype frequencies of ABCB1 rs2032582 and SLCO1B1 rs4149015; describ...

Full Article
  • Article
  • Open Access
1 Citations
2,093 Views
26 Pages
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The Microbiological Background of Medication-Related Osteonecrosis of the Jaw (MRONJ): Clinical Evidence Based on Traditional Culture and Molecular Biological Detection Methods

  • Zsanett Kövér,
  • Márió Gajdács,
  • Beáta Polgár,
  • Dóra Szabó and
  • Edit Urbán
Antibiotics2025, 14(2), 203;https://doi.org/10.3390/antibiotics14020203

15 February 2025

Background: Medication-related osteonecrosis of the jaw (MRONJ) is a common adverse event following antiresorptive treatment, leading to chronic inflammation and exposed, necrotic bone surfaces in the jawbone. There is an increasing recognition of th...

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