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Antibiotics, Volume 13, Issue 12

December 2024 - 131 articles

Cover Story: Periprosthetic joint infection (PJI) is an increasingly common and deleterious complication after joint replacement surgery, requiring surgery and prolonged antibiotic therapy. Vancomycin is commonly used for PJI caused by staphylococci, but our findings show that standard dosing regimens often fail to achieve therapeutic levels. Our study thus highlights the limitations of vancomycin therapy and emphasizes the importance of individualized dosing and regular monitoring. Alternative agents, such as daptomycin and dalbavancin, which do not require as extensive monitoring, could perhaps be used to improve outcomes after PJI. View this paper
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Articles (131)

  • Article
  • Open Access
1 Citations
1,366 Views
19 Pages

Identification and Bioactivity Analysis of a Novel Bacillus Species, B. maqinnsis sp. nov. Bos-x6-28, Isolated from Feces of the Yak (Bos grunniens)

  • Qiang Ma,
  • Xin Xiang,
  • Yan Ma,
  • Guangzhi Li,
  • Xingyu Liu,
  • Boai Jia,
  • Wenlin Yang,
  • Hengxia Yin and
  • Benyin Zhang

23 December 2024

Background: The identification of novel bacterial species from the intestines of yaks residing on the Qinghai–Tibet Plateau is pivotal in advancing our understanding of host–microbiome interactions and represents a promising avenue for mi...

  • Article
  • Open Access
1,622 Views
10 Pages

Study on the Efficacy and Safety of Tedizolid in Japanese Patients

  • Kazuhiro Ishikawa,
  • Yasumasa Tsuda and
  • Nobuyoshi Mori

23 December 2024

Background/Objective: Tedizolid (TZD), an oxazolidinone, causes fewer adverse events than linezolid (LZD). However, studies on the long-term efficacy and safety of TZD, particularly in patients with hematological malignancies (HMs), remain limited. T...

  • Brief Report
  • Open Access
1,279 Views
8 Pages

Efficacy of Cefiderocol Against Endophthalmitis Isolates

  • Brennan Schilling,
  • Michael Hii,
  • Hazel Q. Shanks,
  • Eric G. Romanowski,
  • Jonathan B. Mandell,
  • Robert M. Q. Shanks and
  • Michael Zegans

23 December 2024

Background/Objectives: Endophthalmitis is an intraocular microbial infection that can lead to permanent blindness, even with prompt anti-microbial therapy. Multi-drug-resistant organisms are on the rise, potentially limiting the efficacy of current e...

  • Article
  • Open Access
1 Citations
1,922 Views
12 Pages

Comparative Genome Analysis of Canine Frederiksenia canicola Isolates

  • Marianna Domán,
  • Krisztina Pintér,
  • Boglárka Dóra Pollák,
  • Ágnes Pintér,
  • Enikő Wehmann,
  • Miklós Tenk and
  • Tibor Magyar

22 December 2024

Background/Objectives: The One Health approach is crucial for managing and controlling the spread of antimicrobial resistance. Frederiksenia canicola is a recently identified bacterial species that seems to be a component of the oral microbiota of do...

  • Article
  • Open Access
1 Citations
2,092 Views
20 Pages

Bacterial Pathogen Profiles and Antibiotic Resistance in Pediatric Leukemia Patients: Insights for Optimizing Infection Management in Immunocompromised Children

  • Cristina Elena Singer,
  • Alin Iulian Silviu Popescu,
  • Renata Maria Văruț,
  • Mihaela Popescu,
  • Dira Loredana,
  • Kristina Radivojevic and
  • Petrescu Ileana Octavia

22 December 2024

Background: This study investigates bacterial etiology and antibiotic resistance in pediatric leukemia patients to determine the impact of chronic pathology on treatment efficacy. Methods: Thirty cases of children aged 1–16 years (18 boys, 12 g...

  • Article
  • Open Access
2 Citations
2,623 Views
10 Pages

22 December 2024

Background/Objectives: Sepsis, a life-threatening organ dysfunction caused by a dysregulated host response to infection, remains a major challenge in ICUs. This study evaluated whether combining haemoadsorption therapy with continuous renal replaceme...

  • Article
  • Open Access
2 Citations
3,218 Views
22 Pages

20 December 2024

Background: In recent years, significant resistance of microorganisms to antibiotics has been observed. A biofilm is a structure that significantly aids the survival of the microbial population and also significantly affects its resistance. Methods:...

  • Article
  • Open Access
1 Citations
8,281 Views
11 Pages

The Effect of Medium-Chain Triglycerides Oil on Candida albicans and Streptococcus mutans in Planktonic and Mucosal Models

  • Hiba Rashid Alyami,
  • Yan Wu,
  • Abdulwahab Aljughaiman,
  • Ting Li,
  • Abdullah Almulhim,
  • Joseph M. Bliss and
  • Jin Xiao

20 December 2024

Despite MCT oil’s potential antimicrobial benefits for gastrointestinal health, its effects on disrupting cariogenic pathogens on oral mucosal surfaces remain underexplored. This study evaluated the impact of MCT oil on the adhesion and invasio...

  • Article
  • Open Access
1,943 Views
21 Pages

Phenotypic and Genomic Characterization of ESBL- and AmpC-β-Lactamase-Producing Enterobacterales Isolates from Imported Healthy Reptiles

  • Franziska Unger,
  • Tobias Eisenberg,
  • Ellen Prenger-Berninghoff,
  • Ursula Leidner,
  • Torsten Semmler and
  • Christa Ewers

20 December 2024

Background/Objectives: Reptiles are known reservoirs for members of the Enterobacterales. We investigated antimicrobial resistance (AMR) patterns, the diversity of extended-spectrum-/AmpC-β-lactamases (ESBL/AmpC) genes and the genomic organizati...

  • Article
  • Open Access
1 Citations
1,974 Views
16 Pages

Bioactive Compounds Isolated from a Marine Sponge Selectively Inhibit Neisseria gonorrhoeae

  • Omar E. Christian,
  • Dreyona A. Perry,
  • Alaa I. Telchy,
  • Preston N. Walton and
  • Daniel Williams

19 December 2024

Background/Objectives: Neisseria gonorrhoeae is the third most common sexually transmitted infection (STI), which may become untreatable soon if resistance continues to drastically increase. Due to increases in resistance to recommended antibiot...

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Antibiotics - ISSN 2079-6382Creative Common CC BY license