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Antibiotics, Volume 13, Issue 11

November 2024 - 110 articles

Cover Story: In recent decades, bacterial antimicrobial resistance (AMR) has become one of the leading threats to public health. As of 2050, deaths associated with AMR are expected to reach 8.22 million. By this time, global economic losses will total USD 6.1 trillion annually, while also leading to a pronounced increase in extreme poverty, as economies of low-income countries are disproportionally affected. In light of this, there is an urgent need for the widespread availability of newly developed antimicrobial substances, along with well-defined methods and guidelines for laboratories to advise on their use. This study aimed to evaluate and compare the performance of different assays for antimicrobial susceptibility testing for reserve antibiotics in carbapenem-resistant Enterobacterales, Pseudomonas aeruginosa, and Acinetobacter baumannii. View this paper
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Articles (110)

  • Article
  • Open Access
7 Citations
3,359 Views
20 Pages

The Characterisation of Carbapenem-Resistant Acinetobacter baumannii and Klebsiella pneumoniae in a Teaching Hospital in Malaysia

  • Min Yi Lau,
  • Sasheela Ponnampalavanar,
  • Chun Wie Chong,
  • Jacky Dwiyanto,
  • Yee Qing Lee,
  • Jia Jie Woon,
  • Zhi Xian Kong,
  • Azmiza Syawani Jasni,
  • Michelle Chin Chin Lee and
  • Unaizah Hanum Obaidellah
  • + 1 author

20 November 2024

Background/Objectives: The emergence and dissemination of carbapenem-resistant organisms, particularly Acinetobacter baumannii and Klebsiella pneumoniae, pose a significant threat to healthcare systems worldwide. This retrospective study aims to char...

  • Review
  • Open Access
17 Citations
3,022 Views
21 Pages

20 November 2024

The uncontrolled emergence of multidrug-resistant mycobacterial strains presents as the primary determinant of the present crisis in antimycobacterial therapeutics and underscores tuberculosis (TB) as a daunting global health concern. There is an urg...

  • Brief Report
  • Open Access
3 Citations
2,516 Views
7 Pages

Rapid Detection of Carbapenemases Using NG-Test® CARBA 5 in Positive Blood Cultures: A Diagnostic Test Study

  • Diana Munguia-Ramos,
  • Luis Fernando Xancal-Salvador,
  • Verónica Esteban-Kenel,
  • Narciso Ortiz-Conchi,
  • Ricardo Antonio Jaimes-Aquino,
  • Miguel Mendoza-Rojas,
  • Axel Cervantes-Sánchez,
  • Steven Méndez-Ramos,
  • Hector Orlando Rivera-Villegas and
  • Sandra Rajme-Lopez
  • + 8 authors

20 November 2024

Background: Infections due to carbapenem-resistant Gram-negative bacteria are emerging as an important challenge in health-care settings and a growing concern worldwide. Lateral flow immunoassay NG-Test® CARBA 5 can detect the five most reported...

  • Article
  • Open Access
1 Citations
2,549 Views
18 Pages

Antibiotic Prescribing Decisions for Upper Respiratory Tract Infections Among Primary Healthcare Physicians in China: A Mixed-Methods Approach Based on the Theory of Planned Behavior

  • Muhtar Kadirhaz,
  • Yushan Zhang,
  • Nan Zhao,
  • Iltaf Hussain,
  • Sen Xu,
  • Miaomiao Xu,
  • Chengzhou Tang,
  • Wei Zhao,
  • Yi Dong and
  • Yu Fang
  • + 1 author

20 November 2024

Objectives: In China, primary healthcare (PHC) facilities have high antibiotic prescribing rates for upper respiratory tract infections (URTIs), which are primarily viral and self-limited. This study aimed to identify the main factors influencing PHC...

  • Article
  • Open Access
2 Citations
2,435 Views
12 Pages

Model-Based Dose Identification of Dalbavancin for Long-Term Suppressive Outpatient Treatment of Ventricular Assist Device Infections

  • Ute Chiriac,
  • Uwe Liebchen,
  • Otto Roman Frey,
  • Heike Lanzinger,
  • Sabrina Klein,
  • Torsten Hoppe-Tichy,
  • Matthias Karck,
  • Anna Meyer and
  • Benedict Morath

20 November 2024

Increasing evidence suggests that dalbavancin is an effective long-term treatment for ventricular assist device (VAD) infections, with various prolonged dosing regimens currently in use. This retrospective study aimed to assess dalbavancin pharmacoki...

  • Article
  • Open Access
1 Citations
1,771 Views
17 Pages

19 November 2024

Background: The use of antibiotic-loaded bone cements (ALBCs) in arthroplasty has been well established for the prevention and treatment of infections. Tigecycline (Tig), a broad-spectrum antibiotic, has shown efficacy against various pathogens, incl...

  • Article
  • Open Access
5 Citations
1,692 Views
17 Pages

Immunomodulatory Effects of the Tobacco Defensin NaD1

  • Ekaterina I. Finkina,
  • Ivan V. Bogdanov,
  • Olga V. Shevchenko,
  • Serafima I. Fateeva,
  • Anastasia A. Ignatova,
  • Sergey V. Balandin and
  • Tatiana V. Ovchinnikova

19 November 2024

Background/Objectives: Defensins are important components of the innate plant immune system, exhibiting antimicrobial activity against phytopathogens, as well as against fungi pathogenic to humans. Along with antifungal activity, plant defensins are...

  • Article
  • Open Access
1,603 Views
15 Pages

Proteomic Analysis of Vibrio parahaemolyticus-Stimulated Pinctada martensii Proteins for Antimicrobial Activity, Potential Mechanisms, and Key Components

  • Haisheng Lin,
  • Weiqiang Shen,
  • Bei Luo,
  • Wenhong Cao,
  • Xiaoming Qin,
  • Jialong Gao,
  • Zhongqin Chen,
  • Huina Zheng and
  • Bingbing Song

19 November 2024

Background: Bacterial infections are a major challenge in food processing and public health, and there is an urgent need to develop novel antimicrobial agents. Objectives: The purpose of this study is to investigate the potential mechanism and key co...

  • Article
  • Open Access
2 Citations
2,992 Views
12 Pages

Evaluating the Efficacy of Inhaled Colistin via Two Nebulizer Types in Ventilator-Associated Pneumonia: Prospective Randomized Trial

  • Chung-Chi Huang,
  • Tien-Pei Fang,
  • Chieh-Mo Lin,
  • Chien-Ming Chu,
  • Hsuan-Ling Hsiao,
  • Jui-Fang Liu,
  • Hsin-Hsien Li,
  • Li-Chung Chiu,
  • Kuo-Chin Kao and
  • Chin-Hsi Kuo
  • + 2 authors

19 November 2024

Backgroud: This prospective randomized trial evaluated the clinical efficacy of inhaled colistin administered through two distinct nebulizer types, a vibrating mesh nebulizer (VMN) and a jet nebulizer (JN), in the treatment of ventilator-associated p...

  • Review
  • Open Access
5 Citations
3,963 Views
28 Pages

Screening Methods for Antimicrobial Residues in the Dairy Chain—The Past and the Present

  • Pavlína Navrátilová,
  • Lenka Vorlová,
  • Sandra Dluhošová,
  • Klára Bartáková,
  • Oto Hanuš and
  • Eva Samková

19 November 2024

The presence of residues of antimicrobial substances in milk has been an important hygienic and technological parameter of raw milk quality since the 1960s. The presented review focuses on screening methods (microbiological inhibition methods and rap...

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Antibiotics - ISSN 2079-6382