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Antibiotics
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Prevention, Diagnostic and Antimicrobial Treatment of Periprosthetic Joint Infection—Proven Meets...
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Prevention, Diagnostic and Antimicrobial Treatment of Periprosthetic Joint Infection—Proven Meets Innovative, Complementary Approaches

A special issue of Antibiotics (ISSN 2079-6382).

Deadline for manuscript submissions: closed (30 November 2024) | Viewed by 3233

Special Issue Editors

Prof. Dr. Mustafa Citak

E-Mail Website
Guest Editor
Department of Orthopaedic Surgery, Helios ENDO-Klinik Hamburg, Hamburg, Germany
Interests: arthroplasty; revision arthroplasty; periprosthetic joint infection
Special Issues, Collections and Topics in MDPI journals
Dr. Jochen Salber

E-Mail Website
Guest Editor
Department of Experimental Surgery, Ruhr-University Bochum, Bochum, Germany
Interests: antimicrobial biomaterials; revision arthroplasty; periprosthetic joint infections
Special Issues, Collections and Topics in MDPI journals
Dr. Osman Çiloğlu

E-Mail Website
Guest Editor
Adana City Training and Research Hospital, Department of Orthopedic and Traumatology, Adana, Turkey
Interests: arthroplasty; revision arthroplasty; periprosthetic joint infection

Special Issue Information

Dear Colleagues,

We are thrilled to announce our Special Issue focusing on "Prevention, Diagnostic and Antimicrobial Treatment of Periprosthetic Joint Infection—Proven Meets Innovative, Complementary Approaches". Periprosthetic joint infection (PJI) remains a significant challenge in orthopedic surgery, necessitating comprehensive strategies for prevention, reliable diagnostic methods and effective antimicrobial treatments. Our aim in this collection is to bring together current research findings on proven and novel approaches to the prevention, diagnosis and treatment of PJIs and to combine them with expert knowledge on various aspects of PJI management.

This Special Issue serves as an essential resource for orthopedic surgeons, infectious disease specialists, microbiologists, and healthcare professionals committed to addressing the complexities of periprosthetic joint infections and enhancing patient care.

Prof. Dr. Mustafa Citak
Dr. Jochen Salber
Dr. Osman Çiloğlu
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antibiotics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • periprosthetic joint infection
  • antimicrobial treatments
  • orthopedics
  • joint arthroplasty

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Further information on MDPI's Special Issue policies can be found here.

Published Papers (2 papers)

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Research

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10 pages, 424 KiB  
Article
Two-Year Follow-Up Shows Gentamicin-Coated Tibial Nails Reduce Infection Rates in Open Tibial Fractures
by Álvaro I. Zamorano, Matías A. Vaccia, Carlos F. Albarrán, Rodrigo I. Parra, Tomás Turner, Ignacio A. Rivera, Tomás Errázuriz, Andrés Oyarzún, Osvaldo A. Garrido, Pablo F. Suárez, Pierluca Zecchetto and Luis A. Bahamonde
Antibiotics 2025, 14(6), 532; https://doi.org/10.3390/antibiotics14060532 - 22 May 2025
Viewed by 159
Abstract
Introduction: Open tibial fractures carry a high risk of fracture-related infection (FRI), and prevention typically relies on early antibiotics and debridement. However, achieving optimum local antibiotic concentration remains challenging. Gentamicin-coated intramedullary nails (GCN) have been developed to prevent biofilm formation, showing short-term [...] Read more.
Introduction: Open tibial fractures carry a high risk of fracture-related infection (FRI), and prevention typically relies on early antibiotics and debridement. However, achieving optimum local antibiotic concentration remains challenging. Gentamicin-coated intramedullary nails (GCN) have been developed to prevent biofilm formation, showing short-term efficacy without interfering with fracture healing. Medium- and long-term data on GCN use are limited. This study aimed to assess the effectiveness and safety of GCN in medium-term follow-up. Methods: A prospective cohort study of patients with open tibial fractures was treated with GCN under a standardized protocol, with a minimum follow-up of 24 months. Patients with traumatic amputations, protocol infringement, or loss of follow-up were excluded. The analysis assessed overall FRI incidence by Gustilo–Anderson (GA) classification. Results: Of 907 patients, 139 were included, with 2 lost to follow-up. The overall FRI incidence was 8.8%, the average healing time was 34.3 weeks, and the non-union rate was 2.2%. FRI incidence by GA classification was 0% in GA I, 2.9% in GA II, 2.9% in GA IIIA, 44.4% in GA IIIB, and 33.3% in GA IIIC. External fixation (EF) was required in 45.2% of cases, with 16.1% developing FRI (14.3% in GA II, 2.8% in GA IIIA, 50% in GA IIIB, and 33.3% in GA IIIC). In non-EF cases, FRI occurred in 2.7% of patients (2.9% in GA IIIA and 25% in GA IIIB). No adverse effects were reported due to locally administered gentamicin. Conclusions: In the medium term, GCN has consistently demonstrated safety and efficacy in preventing FRI in open tibial fractures, particularly in GA IIIA cases, even with the use of temporary EF. These findings highlight its potential as a valuable tool in managing open tibial fractures. However, further studies with long-term outcomes are needed to evaluate its effectiveness in GA IIIB and IIIC fractures. Full article
(This article belongs to the Special Issue Prevention, Diagnostic and Antimicrobial Treatment of Periprosthetic Joint Infection—Proven Meets Innovative, Complementary Approaches)
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Review

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10 pages, 256 KiB  
Review
The Role of Rifampin in Prosthetic Joint Infections: Efficacy, Challenges, and Clinical Evidence
by Jakrapun Pupaibool
Antibiotics 2024, 13(12), 1223; https://doi.org/10.3390/antibiotics13121223 - 17 Dec 2024
Cited by 1 | Viewed by 2689
Abstract
Rifampin is a crucial antibiotic in the management of prosthetic joint infections (PJI), particularly due to its effectiveness against staphylococcal bacteria and its ability to penetrate and disrupt biofilms. This review evaluates rifampin’s role by examining its mechanism of action, clinical efficacy, and [...] Read more.
Rifampin is a crucial antibiotic in the management of prosthetic joint infections (PJI), particularly due to its effectiveness against staphylococcal bacteria and its ability to penetrate and disrupt biofilms. This review evaluates rifampin’s role by examining its mechanism of action, clinical efficacy, and integration into treatment regimens based on recent evidence and guidelines. Rifampin’s synergistic effects with other antibiotics, such as β-lactams and vancomycin, enhance bacterial eradication, and some evidence shows that it improves patient outcomes. However, evidence supporting its use is limited by the scarcity of robust human clinical trials, and challenges such as potential drug interactions and resistance development necessitate careful management. Ongoing research is needed to refine its use and address existing limitations in clinical practice. Full article
(This article belongs to the Special Issue Prevention, Diagnostic and Antimicrobial Treatment of Periprosthetic Joint Infection—Proven Meets Innovative, Complementary Approaches)
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