Infection-Related Ventilator-Associated Complications in Critically Ill Patients with Trauma: A Retrospective Analysis
Abstract
:1. Introduction
2. Materials and Methods
- -
- ≥16 years of age;
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- Primary diagnosis of trauma;
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- MV requirement ≥ four consecutive days.
3. Results
4. Discussion
5. Limitations
6. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Total n = 88 | NO IVAC/PVAP n = 62 (70.5%) | IVAC/PVAP n = 26 (29.5%) | p-Value * | ||
---|---|---|---|---|---|
Baseline characteristics | |||||
Age (years) | mean (SD) | 56.7 (±18.0) | 58.68 (±17.2) | 52.1 (±19.5) | 0.137 |
Sex, male | n (%) | 66 (75) | 45 (72.6) | 21 (80.8) | 0.418 |
Trauma characteristics | |||||
GCSt | median (IQR) | 11 (8) | 12.5 (8) | 7 (9) | 0.068 |
TBI | n (%) | 88 (100) | 62 (100) | 26 (100) | 0.218 |
mild TBI | n (%) | 13 (14.8) | 9 (14.5) | 4 (15.4) | |
moderate TBI | n (%) | 39 (44.3) | 31 (50) | 8 (30.8) | |
severe TBI | n (%) | 36 (40.9) | 22 (35.5) | 14 (53.8) | |
Pupils, abnormal | n (%) | 15 (17.0) | 9 (14.5) | 6 (23.1) | 0.330 |
Pupils, normal | n (%) | 73 (83.0) | 53 (85.5) | 20 (76.9) | |
ISS | median (IQR) | 34 (17.5) | 34 (16) | 41 (16) | 0.040 |
AIS t | median (IQR) | 3 (4) | 3 (4) | 3 (4) | 0.493 |
AIS h | median (IQR) | 4 (3.5) | 3,5 (4) | 4 (2) | 0.774 |
AIS a | median (IQR) | 0 (3) | 0 (3) | 2 (4) | 0.021 |
AIS s | median (IQR) | 0 (3) | 0 (3) | 1 (3) | 0.317 |
AIS e | median (IQR) | 0 (1) | 0 (1) | 0 (1) | 0.912 |
AIS f | median (IQR) | 0 (3) | 0 (3) | 0 (3) | 0.504 |
ICU characteristics/associated treatments | |||||
ICU LoS (days) | median (IQR) | 8.5 (10) | 7 (5) | 16.5 (8) | <0.001 |
MV duration (days) | median (IQR) | 8 (8) | 6 (5) | 15 (9) | <0.001 |
Tracheostomy | YES n (%) | 25 (28.4) | 11 (17.7) | 14 (53.8) | <0.001 |
NO n (%) | 63 (71.6) | 51 (82.3) | 12 (46.2) | ||
ABT prophylaxis * | YES n (%) | 16 (18.2) | 13 (21.0) | 3 (11.5) | 0.295 |
NO n (%) | 72 (81.8) | 49 (79.0) | 23 (88.5) | ||
Hemofiltration | n (%) | 13 (14.8) | 8 (12.9) | 5 (19.2) | 0.445 |
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Russo, E.; Antonini, M.V.; Sica, A.; Dell’Amore, C.; Martino, C.; Gamberini, E.; Bissoni, L.; Circelli, A.; Bolondi, G.; Santonastaso, D.P.; et al. Infection-Related Ventilator-Associated Complications in Critically Ill Patients with Trauma: A Retrospective Analysis. Antibiotics 2023, 12, 176. https://doi.org/10.3390/antibiotics12010176
Russo E, Antonini MV, Sica A, Dell’Amore C, Martino C, Gamberini E, Bissoni L, Circelli A, Bolondi G, Santonastaso DP, et al. Infection-Related Ventilator-Associated Complications in Critically Ill Patients with Trauma: A Retrospective Analysis. Antibiotics. 2023; 12(1):176. https://doi.org/10.3390/antibiotics12010176
Chicago/Turabian StyleRusso, Emanuele, Marta Velia Antonini, Andrea Sica, Cristian Dell’Amore, Costanza Martino, Emiliano Gamberini, Luca Bissoni, Alessandro Circelli, Giuliano Bolondi, Domenico Pietro Santonastaso, and et al. 2023. "Infection-Related Ventilator-Associated Complications in Critically Ill Patients with Trauma: A Retrospective Analysis" Antibiotics 12, no. 1: 176. https://doi.org/10.3390/antibiotics12010176