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Biosensors, Volume 12, Issue 5

May 2022 - 102 articles

Cover Story: Our research incorporates the DNA–gold affinity interaction into an electrochemical nucleic-acid-based direct adsorption platform for the voltammetric detection of HOTAIR long noncoding RNA. Our platform utilizes highly specific and sensitive nanomaterials coupled with screen-printed gold electrodes. The assay features three main steps: (i) magnetic bead capture of HOTAIR targets, (ii) magnetic purification and isolation of targets, and (iii) direct adsorption and detection via interfacial affinity interaction. We demonstrate detection as low as 1 pM for samples containing designated proportions of synthetic HOTAIR spiked in buffer as well as healthy plasma samples. Our method shows huge potential in diagnostics due to its disposable, simple, inexpensive, easy-to-store, and portable design. View this paper
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Articles (102)

  • Article
  • Open Access
21 Citations
4,810 Views
15 Pages

Electrochemical DNA Sensor Based on Carbon Black—Poly(Methylene Blue)—Poly(Neutral Red) Composite

  • Dominica Kappo,
  • Dmitry Shurpik,
  • Pavel Padnya,
  • Ivan Stoikov,
  • Alexey Rogov and
  • Gennady Evtugyn

12 May 2022

The detection of small molecules interacting with DNA is important for the assessment of potential hazards related to the application of rather toxic antitumor drugs, and for distinguishing the factors related to thermal and oxidative DNA damage. In...

  • Article
  • Open Access
4 Citations
3,412 Views
11 Pages

12 May 2022

MicroRNAs (miRNAs) are regarded as a rising star in the biomedical industry. By monitoring slight increases in miRNA-21 levels, the possibilities of multi-type malignancy can be evaluated more precisely and earlier. However, the inconvenience and ins...

  • Article
  • Open Access
8 Citations
2,753 Views
28 Pages

11 May 2022

The time-dependent response of metal-detecting whole-cell luminescent bacterial sensors is impacted by metal speciation/bioavailability in solution. The comprehensive understanding of such connections requires the consideration of the bacterial energ...

  • Article
  • Open Access
8 Citations
2,979 Views
13 Pages

A Novel Perturbed Spiral Sheathless Chip for Particle Separation Based on Traveling Surface Acoustic Waves (TSAW)

  • Miaomiao Ji,
  • Yukai Liu,
  • Junping Duan,
  • Wenxuan Zang,
  • Yongsheng Wang,
  • Zeng Qu and
  • Binzhen Zhang

11 May 2022

The combination of the new perturbed spiral channel and a slanted gold interfingered transducer (IDT) is designed to achieve precise dynamic separation of target particles (20 μm). The offset micropillar array solves the defect that the high-width...

  • Article
  • Open Access
13 Citations
3,114 Views
15 Pages

11 May 2022

A novel electrochemical sensor designed to recognize and detect tartrazine (TZ) was constructed based on a molecularly imprinted polydopamine (MIPDA)-coated nanocomposite of platinum cobalt (PtCo) nanoalloy-functionalized graphene oxide (GO). The nan...

  • Article
  • Open Access
35 Citations
5,532 Views
11 Pages

All-in-One Digital Microfluidics System for Molecular Diagnosis with Loop-Mediated Isothermal Amplification

  • Siyi Hu,
  • Yuhan Jie,
  • Kai Jin,
  • Yifan Zhang,
  • Tianjie Guo,
  • Qi Huang,
  • Qian Mei,
  • Fuqiang Ma and
  • Hanbin Ma

11 May 2022

In this study, an “all-in-one” digital microfluidics (DMF) system was developed for automatic and rapid molecular diagnosis and integrated with magnetic bead-based nucleic acid extraction, loop-mediated isothermal amplification (LAMP), an...

  • Review
  • Open Access
28 Citations
6,387 Views
32 Pages

From Triboelectric Nanogenerator to Polymer-Based Biosensor: A Review

  • Yin Lu,
  • Yajun Mi,
  • Tong Wu,
  • Xia Cao and
  • Ning Wang

11 May 2022

Nowadays, self-powered wearable biosensors that are based on triboelectric nanogenerators (TENGs) are playing an important role in the continuous efforts towards the miniaturization, energy saving, and intelligence of healthcare devices and Internets...

  • Article
  • Open Access
3 Citations
2,845 Views
16 Pages

Rapidly Measuring Scattered Polarization Parameters of the Individual Suspended Particle with Continuously Large Angular Range

  • Yan Chen,
  • Hongjian Wang,
  • Ran Liao,
  • Hening Li,
  • Yihao Wang,
  • Hu Zhou,
  • Jiajin Li,
  • Tongyu Huang,
  • Xu Zhang and
  • Hui Ma

10 May 2022

Suspended particles play a vital role in aquatic environments. We propose a method to rapidly measure the scattered polarization parameters of individual suspended particles with continuously large angular range (PCLAR), from 60° to 120° in o...

  • Article
  • Open Access
29 Citations
5,209 Views
14 Pages

The Impact of Glucose Oxidase Immobilization on Dendritic Gold Nanostructures on the Performance of Glucose Biosensors

  • Laura Sakalauskiene,
  • Anton Popov,
  • Asta Kausaite-Minkstimiene,
  • Arunas Ramanavicius and
  • Almira Ramanaviciene

10 May 2022

In recent years, many efforts have been made to develop rapid, sensitive and user-friendly glucose biosensors for monitoring blood glucose concentration in patients. In this study, the electrochemical glucose biosensors based on graphite rod (GR) ele...

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Biosensors - ISSN 2079-6374