Special Issue "Special Issue in Honor of Professor Bansi D. Malhotra—From Nanosystems to a Biosensing Prototype for an Efficient Diagnostic"

A special issue of Biosensors (ISSN 2079-6374). This special issue belongs to the section "Nano- and Micro-Technologies in Biosensors".

Deadline for manuscript submissions: 31 March 2022.

Special Issue Editors

Prof. Dr. Ajeet Kaushik
E-Mail Website
Guest Editor
Department of Natural Sciences Division of Sciences, Arts & Mathematics (SAM) Florida Polytechnic University, Lakeland, FL, USA
Interests: functional materials; polymers; sensors; biosensors; nanomedicine drug delivery systems
Special Issues, Collections and Topics in MDPI journals
Dr. Pratima Solanki
E-Mail Website
Guest Editor
Special Center for Nano Science, Jawaharlal Nehru University, New Delhi, India
Interests: nanosensor–biosensor; microfluidic; nano-biointeraction; diagnosis
Dr. Raju Khan
E-Mail Website
Guest Editor
CSIR-Advanced Materials & Processes Research Institute (AMPRI), Bhopal, MP, India
Interests: electrochemical and fluorescence-based biosensor diagnostics; biomarker detection; nanomaterials
Prof. Dr. Yogendra Kumar Mishra
E-Mail Website
Guest Editor
Mads Clausen Institute, SDU NanoSYD, University of Southern Denmark, Alsion 2, 6400 Sønderborg, Denmark
Interests: smart materials; zinc oxide tetrapods; biomaterials; nanocatalysis; green 3D nanotechnology
Special Issues, Collections and Topics in MDPI journals
Dr. Sonu Gandhi
E-Mail Website
Guest Editor
DBT-National Institute of Animal Biotechnology (NIAB), Hyderabad, India
Interests: diagnostics; biosensors; nanotechnology; biomarkers; cancers

Special Issue Information

Dear Colleagues,

Recently, the success of the Internet of Medical Things (IoMT)-assisted miniaturized biomedical electronics has emerged as a potential analytical tool to manage a disease. As a recent example, diagnostics of viral infectious diseases such as COVID-19 infection diagnostics seems manageable due to the collective approach of artificial intelligence (AI for predictive analysis), IoMT, rapid testing systems, performance at point of care (POC), bioinformatics sharing along with rapid analytics, and timely therapy decision. An optimized combination of nano-enabled biosensing, POC testing, support of AI, and testing interfaced with IoMT have emerged and are very useful not for efficient diagnostics but also for making disease management possible at personalized level. In addition to the desired and controlled performance, these systems need significant improvement in terms of 1) developing a sensing prototype based on smart optoelectric nanosystems to achieve high sensitivity and low detection limit, and selectivity, 2) selecting a real sample source, which requires accurate diagnostics without interferents and loss in order to validate the sensor for clinical application in a scaled up setting.  

Keeping the above into consideration, and with the aim of an intelligent approach toward a better health, this Special Issue will honor Prof. B.D. Malhotra, PhD, FNA, FNASc, to acknowledge his contribution in the field of Biosensors. Prof. Malhotra (Professor and Ex-Head, Department of Biotechnology, Delhi Technological University, India, who also served as Senior Scientist and founder of the Biomedical Instrumentation Section at National Physical Laboratory, India, and) is well known as the father of biosensors in India and a leading, accomplished scientist at the international level.

This Special Issue will be focused on collecting original research and comprehensive review articles based on the following topics:

  • Biosensors for metabolite diagnostics;
  • Biosensors for agro-food safety and quality assessment;
  • Biosensors for cancer diagnostics;
  • Biosensors for infectious disease management;
  • Lab-on-a-chip supported biosensing systems;
  • Microfluidic devices for efficient biosensing;
  • Point-of-care biosensing for disease management;
  • Efficient biosensing for brain functional assessment;
  • Artificial Intelligence (AI) and Internet of Medical Things (IoMT) for intelligent healthcare;
  • Aspects of 3D and green technology for efficient biosensing.

Prof. B.D. Malhotra, Ph.D., FNA, FNASc

Dr. B.D. Malhotra received his PhD from the University of Delhi, Delhi, in 1980. He has published 330 papers in refereed international journals (Citations: 23570 -index: 83), has filed 11 patents (in India and overseas), and has co-authored a textbook on Nanomaterials for Biosensors: Fundamentals and Applications and Biosensors: Fundamentals and Applications. He is the recipient of the National Research Development Corporation Award 2005 for the invention of a ‘Blood Glucose Biochemical Analyzer’ and is a Fellow of the Indian National Science Academy, the National Academy of Sciences, India, and an Academician of the Asia Pacific Academy of Materials (APAM). His current research activities include biosensors, point-of-care diagnostics, nano-biomaterials, biofuel cells, ordered molecular assemblies, conducting polymers, Langmuir–Blodgett films, self-assembled monolayers, advanced functionalized nanosystems, hybrid nanosystems, nano-biotechnology, biomedical engineering, and biomolecular electronics.

Since 1994, he has explored functional materials for biosensing applications. His efforts initiated biosensing research in India, and as a result, this field is growing rapidly nationwide. His research is multidisciplinary and focuses on detecting targeted biomarkers not only in a physiological range but at a very low level as well. Such systems are emerging as efficient analytical tools to manage disease progression, therapy decisions, and therapy assessment at POC applications. Such approaches are of tunable performance and can be optimized for diagnostics in personalized healthcare settings if supported by artificial intelligence (AI) and the Internet of Medical Things (IoMT). Dr Malhotra is currently a DST-SERB (Govt. of India) Distinguished Fellow and an Adjunct Professor with the Department of Biotechnology, Delhi Technological University, Delhi, India.

He is a phenomenal mentor and supervisor and can be contacted via e-mail at [email protected] or [email protected]

Prof. Dr. Ajeet Kaushik
Dr. Pratima Solanki
Dr. Raju Khan
Prof. Dr. Yogendra Kumar Mishra
Dr. Sonu Gandhi
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biosensors is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Published Papers (3 papers)

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Editorial

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Editorial
From Nanosystems to a Biosensing Prototype for an Efficient Diagnostic: A Special Issue in Honor of Professor Bansi D. Malhotra
Biosensors 2021, 11(10), 359; https://doi.org/10.3390/bios11100359 - 29 Sep 2021
Cited by 2 | Viewed by 950
Abstract
It has been proven that rapid bioinformatics analysis according to patient health profiles, in addition to biomarker detection at a low level, is emerging as essential to design an analytical diagnostics system to manage health intelligently in a personalized manner. Such objectives need [...] Read more.
It has been proven that rapid bioinformatics analysis according to patient health profiles, in addition to biomarker detection at a low level, is emerging as essential to design an analytical diagnostics system to manage health intelligently in a personalized manner. Such objectives need an optimized combination of a nano-enabled sensing prototype, artificial intelligence (AI)-supported predictive analysis, and Internet of Medical Things (IoMT)-based bioinformatics analysis. Such a developed system began with a prototype demonstration of efficient diseases diagnostics performance is the future diseases management approach. To explore these aspects, the Special Issue planned for the nano-and micro-technology section of MDPI’s Biosensors journal will honor and acknowledge the contributions of Prof. B.D. Malhotra, Ph.D., FNA, FNASc has made in the field of biosensors. Full article
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Review

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Review
Using Graphene-Based Biosensors to Detect Dopamine for Efficient Parkinson’s Disease Diagnostics
Biosensors 2021, 11(11), 433; https://doi.org/10.3390/bios11110433 - 31 Oct 2021
Viewed by 980
Abstract
Parkinson’s disease (PD) is a neurodegenerative disease in which the neurotransmitter dopamine (DA) depletes due to the progressive loss of nigrostriatal neurons. Therefore, DA measurement might be a useful diagnostic tool for targeting the early stages of PD, as well as helping to [...] Read more.
Parkinson’s disease (PD) is a neurodegenerative disease in which the neurotransmitter dopamine (DA) depletes due to the progressive loss of nigrostriatal neurons. Therefore, DA measurement might be a useful diagnostic tool for targeting the early stages of PD, as well as helping to optimize DA replacement therapy. Moreover, DA sensing appears to be a useful analytical tool in complex biological systems in PD studies. To support the feasibility of this concept, this mini-review explores the currently developed graphene-based biosensors dedicated to DA detection. We discuss various graphene modifications designed for high-performance DA sensing electrodes alongside their analytical performances and interference studies, which we listed based on their limit of detection in biological samples. Moreover, graphene-based biosensors for optical DA detection are also presented herein. Regarding clinical relevance, we explored the development trends of graphene-based electrochemical sensing of DA as they relate to point-of-care testing suitable for the site-of-location diagnostics needed for personalized PD management. In this field, the biosensors are developed into smartphone-connected systems for intelligent disease management. However, we highlighted that the focus should be on the clinical utility rather than analytical and technical performance. Full article
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Review
Functional Ionic Liquids Decorated Carbon Hybrid Nanomaterials for the Electrochemical Biosensors
Biosensors 2021, 11(11), 414; https://doi.org/10.3390/bios11110414 - 23 Oct 2021
Viewed by 737
Abstract
Ionic liquids are gaining high attention due to their extremely unique physiochemical properties and are being utilized in numerous applications in the field of electrochemistry and bio-nanotechnology. The excellent ionic conductivity and the wide electrochemical window open a new avenue in the construction [...] Read more.
Ionic liquids are gaining high attention due to their extremely unique physiochemical properties and are being utilized in numerous applications in the field of electrochemistry and bio-nanotechnology. The excellent ionic conductivity and the wide electrochemical window open a new avenue in the construction of electrochemical devices. On the other hand, carbon nanomaterials, such as graphene (GR), graphene oxide (GO), carbon dots (CDs), and carbon nanotubes (CNTs), are highly utilized in electrochemical applications. Since they have a large surface area, high conductivity, stability, and functionality, they are promising in biosensor applications. Nevertheless, the combination of ionic liquids (ILs) and carbon nanomaterials (CNMs) results in the functional ILs-CNMs hybrid nanocomposites with considerably improved surface chemistry and electrochemical properties. Moreover, the high functionality and biocompatibility of ILs favor the high loading of biomolecules on the electrode surface. They extremely enhance the sensitivity of the biosensor that reaches the ability of ultra-low detection limit. This review aims to provide the studies of the synthesis, properties, and bonding of functional ILs-CNMs. Further, their electrochemical sensors and biosensor applications for the detection of numerous analytes are also discussed. Full article
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