Nanomaterials, Volume 14, Issue 4
2024 February-2 - 67 articles
Cover Story: We showed that the physical features of substrates that resemble the extracellular matrix in vivo influence cell behavior. Lung fibroblasts and epithelial cells were cultured on soft polyurethane membranes with different alignments. No cytotoxicity was observed in the cells cultured on both aligned and non-aligned membranes; however, their cytokine release was increased compared to that of cells grown on stiff plastic. Also, the uptake of silica nanoparticles increased more than three-fold in the fibroblasts but not in the epithelial cells. We demonstrated that cell–matrix interaction is substrate- and cell-type-dependent and that the extracellular matrix’s mechanical properties must be considered for effective cell targeting and nanoparticle delivery. View this paper - Issues are regarded as officially published after their release is announced to the table of contents alert mailing list .
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