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Journal of Functional Biomaterials, Volume 16, Issue 6

June 2025 - 38 articles

Cover Story: Superparamagnetic iron oxide (SPIO) nanoparticles injected as a tracer in early-stage cancer patients can be detected accurately by a handheld magnetometer and optimize the lymphatic mapping of sentinel lymph nodes (SLNs). We proved that this detection method is not inferior when compared to pelvic lymphadenectomy, which is the standard of care. The diagnostic accuracy parameters of the SPIO detection of metastatic SLNs evaluated by the Receiver Operating Characteristic (ROC) curve analysis with the area under the ROC curve (AUC) demonstrated a sensitivity of 100% and an AUC of 1.0. The SPIO method was determined to be safe (no adverse events reported), accurate (magnetic sensing remains accurate through its use), and reliable (SPIO retains its signal during surgical management). View this paper
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Articles (38)

  • Article
  • Open Access
2 Citations
1,217 Views
19 Pages

In Vitro Biological Properties Assessment of 3D-Printed Hydroxyapatite–Polylactic Acid Scaffolds Intended for Bone Regeneration

  • Eddy Shan,
  • Cristina Chamorro,
  • Ana Ferrández-Montero,
  • Rosa M. Martin-Rodriguez,
  • Begoña Ferrari,
  • Antonio Javier Sanchez-Herencia,
  • Leire Virto,
  • María José Marín,
  • Elena Figuero and
  • Mariano Sanz

This study evaluated the biological performance in vitro of two 3D-printed hydroxyapatite (HA) and polylactic acid (PLA) composite scaffolds with two different infill densities (50% [HA-PLA50] and 70% [HA-PLA70]). Comparative analysis using MG-63 cel...

  • Review
  • Open Access
1,858 Views
40 Pages

Applications of Osteoimmunomodulation Models in Evaluating Osteogenic Biomaterials

  • Yuhan Wang,
  • Yuzhu He,
  • Yaran Zang,
  • Zijiao Zhang,
  • Guangyao Li,
  • Wenqi Fu and
  • Guowu Ma

The development of osteogenic biomaterials relies on updates in research methodologies. Establishing reasonable modes is the basis for obtaining reliable experimental conclusions. With the advancement in bone immunology, osteoimmunomodulatory propert...

  • Article
  • Open Access
2 Citations
1,177 Views
20 Pages

Controlled Release of Hydrophilic Active Agent from Textile Using Crosslinked Polyvinyl Alcohol Coatings

  • Limor Mizrahi,
  • Rotem Kelman,
  • Efrat Shtriker,
  • David Meridor,
  • Dror Cohen,
  • Meital Portugal-Cohen and
  • Elizabeth Amir

Functional fabrics embedded with active materials that can be released in a controlled manner upon external triggering have been explored for biomedical and cosmetic applications. This study introduces a method for the fabrication of nonwoven fabrics...

  • Article
  • Open Access
1 Citations
1,963 Views
12 Pages

Introduction: Although significant advancements have been made in surgical techniques for reconstructing severely resorbed alveolar bone, achieving predictable regeneration remains a considerable challenge. Many conventional ridge augmentation method...

  • Article
  • Open Access
1,328 Views
15 Pages

Evaluation of Two Alloplastic Biomaterials in a Critical-Size Rat Calvarial Defect Model

  • Amanda Finger Stadler,
  • Marta Liliana Musskopf,
  • Vishal Gohel,
  • Jonathan Reside,
  • Eric Everett,
  • Patricia Miguez and
  • Cristiano Susin

Aim: to evaluate the bone regeneration capacity of two alloplastic biomaterials in a critical-size rat calvarial defect model. Methods: A total of 80 rats were randomized into 8 groups of 10 animals each. An Ø8 mm, critical-size calvarial defe...

  • Review
  • Open Access
1 Citations
2,164 Views
41 Pages

Osteosarcoma (OS), a prevalent primary malignant bone tumor in children and adolescents, has maintained consistent treatment protocols since the 1970s combining surgery, chemotherapy, and radiotherapy. While effective for localized tumors, these stra...

  • Article
  • Open Access
1,646 Views
12 Pages

Background: In this study, we aimed to investigate the association between a patient’s selection of implant treatment for a missing mandibular second molar and the magnitude of occlusal force, masticatory ability, mandibular morphology, and age...

  • Review
  • Open Access
1 Citations
1,563 Views
18 Pages

In Vitro Techniques for Microleakage Evaluation of Coronary Restorative Materials: A Scoping and Mapping Review

  • Sofia Vieira,
  • Carlos Miguel Marto,
  • Ana Coelho,
  • Inês Amaro,
  • Inês Francisco,
  • Francisco Vale,
  • Siri Paulo,
  • Manuel Marques Ferreira,
  • Eunice Carrilho and
  • Anabela Paula

Objectives: To identify the in vitro techniques used for a microleakage evaluation of restorative materials of coronary structure through a scoping and mapping review. Data: This scoping review aims to answer the following question: “what metho...

  • Systematic Review
  • Open Access
1 Citations
1,712 Views
16 Pages

Background: The Er:YAG laser has gained attention in dentistry for its potential to enhance microbial disinfection through targeted photothermal and photoacoustic mechanisms. Objective: This systematic review aimed to evaluate the antibacterial and b...

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J. Funct. Biomater. - ISSN 2079-4983Creative Common CC BY license