Special Issue "Oxidative Stress in Neurodegenerative Diseases: From Preclinical Studies to Clinical Applications"
Deadline for manuscript submissions: 31 July 2019
Oxidative stress plays a significant role in various neurodegenerative diseases, including Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, and amyotrophic lateral sclerosis. A great deal of evidence indicates a cross-talk between oxidative stress, inflammation, proteostasis impairment, mitochondrial dysfunction, and neurodegenerative events. Therefore, neuroprotective molecules with antioxidant properties have received increasing attention as therapeutic and preventive interventions for neurodegenerative diseases. Even though difficulties exist with clinical studies due to the nature of the established progression of neurodegenerative diseases, findings in cell, organism, and animal models, as well as biomarker studies have suggested a relationship between redox status regulation and neuroprotection. In this Special Issue, we will focus on recent advances in the contribution of oxidative stress to various neurodegenerative diseases. Further, we will discuss neuroprotective effects recorded using synthetic and natural molecules with antioxidant properties in preclinical and clinical studies as well as new therapeutic strategies of neuroprotection for neurodegenerative diseases.
Prof. Andrea Tarozzi
Manuscript Submission Information
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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- mechanisms of oxidative stress
- neurodegenerative diseases
- direct and indirect antioxidants
- natural antioxidants
- synthetic antioxidants
- translational research
- neuroprotective molecules