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Journal of Clinical Medicine, Volume 5, Issue 4

2016 April - 10 articles

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Articles (10)

  • Feature Paper
  • Review
  • Open Access
47 Citations
26,647 Views
19 Pages

Management of Status Epilepticus in Children

  • Douglas M. Smith,
  • Emily L. McGinnis,
  • Diana J. Walleigh and
  • Nicholas S. Abend

Status epilepticus is a common pediatric neurological emergency. Management includes prompt administration of appropriately selected anti-seizure medications, identification and treatment of seizure precipitant(s), as well as identification and manag...

  • Article
  • Open Access
43 Citations
27,948 Views
13 Pages

Long-Term Weight Change after Initiating Second-Generation Antidepressants

  • David Arterburn,
  • Tamar Sofer,
  • Denise M. Boudreau,
  • Andy Bogart,
  • Emily O. Westbrook,
  • Mary Kay Theis,
  • Greg Simon and
  • Sebastien Haneuse

(1) Objective: To examine the relationship between the choice of second-generation antidepressant drug treatment and long-term weight change; (2) Methods: We conducted a retrospective cohort study to investigate the relationship between choice of ant...

  • Review
  • Open Access
91 Citations
10,045 Views
15 Pages

Epithelial to mesenchymal transition (EMT) is a process that allows an epithelial cell to acquire a mesenchymal phenotype through multiple biochemical changes resulting in an increased migratory capacity. During cancer progression, EMT is found to be...

  • Review
  • Open Access
252 Citations
17,537 Views
22 Pages

Endothelial to Mesenchymal Transition (EndoMT) in the Pathogenesis of Human Fibrotic Diseases

  • Sonsoles Piera-Velazquez,
  • Fabian A. Mendoza and
  • Sergio A. Jimenez

Fibrotic diseases encompass a wide spectrum of clinical entities including systemic fibrotic diseases such as systemic sclerosis, sclerodermatous graft versus host disease, nephrogenic systemic fibrosis, and IgG4-associated sclerosing disease, as wel...

  • Review
  • Open Access
31 Citations
8,993 Views
17 Pages

Epithelial–mesenchymal transition (EMT) and cell migration are important processes in embryonic development of many tissues as well as oncogenesis. The pituitary gland is a master endocrine tissue and recent studies indicate that Sox2-expressing stem...

  • Review
  • Open Access
292 Citations
19,696 Views
18 Pages

Epithelial-to-mesenchymal transition (EMT) is a key step in development, wound healing, and cancer development. It involves cooperation of signaling pathways, such as transformation growth factor-β (TGF-β), Sonic Hedgehog (SHH), and WNT pathways. The...

  • Review
  • Open Access
14 Citations
9,915 Views
10 Pages

The role of ω3 alpha linolenic acid (ALA) in the maternal diet during pregnancy and lactation, and its effect on the prevention of disease and programming of health in offspring, is largely unknown. Compared to ALA, ω3 docosahexaenoic (DHA) and eicos...

  • Review
  • Open Access
101 Citations
9,996 Views
16 Pages

Osteopontin—A Master Regulator of Epithelial-Mesenchymal Transition

  • Anai N. Kothari,
  • Matthew L. Arffa,
  • Victor Chang,
  • Robert H. Blackwell,
  • Wing-Kin Syn,
  • Jiwang Zhang,
  • Zhiyong Mi and
  • Paul C. Kuo

Osteopontin (OPN) plays an important functional role in both physiologic and pathologic states. OPN is implicated in the progression of fibrosis, cancer, and metastatic disease in several organ systems. The epithelial-mesenchymal transition (EMT), fi...

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J. Clin. Med. - ISSN 2077-0383