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Journal of Clinical Medicine, Volume 5, Issue 4

April 2016 - 10 articles

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Articles (10)

  • Feature Paper
  • Review
  • Open Access
46 Citations
26,363 Views
19 Pages

Management of Status Epilepticus in Children

  • Douglas M. Smith,
  • Emily L. McGinnis,
  • Diana J. Walleigh and
  • Nicholas S. Abend

Status epilepticus is a common pediatric neurological emergency. Management includes prompt administration of appropriately selected anti-seizure medications, identification and treatment of seizure precipitant(s), as well as identification and manag...

  • Article
  • Open Access
42 Citations
26,635 Views
13 Pages

Long-Term Weight Change after Initiating Second-Generation Antidepressants

  • David Arterburn,
  • Tamar Sofer,
  • Denise M. Boudreau,
  • Andy Bogart,
  • Emily O. Westbrook,
  • Mary Kay Theis,
  • Greg Simon and
  • Sebastien Haneuse

(1) Objective: To examine the relationship between the choice of second-generation antidepressant drug treatment and long-term weight change; (2) Methods: We conducted a retrospective cohort study to investigate the relationship between choice of ant...

  • Review
  • Open Access
88 Citations
9,939 Views
15 Pages

Epithelial to mesenchymal transition (EMT) is a process that allows an epithelial cell to acquire a mesenchymal phenotype through multiple biochemical changes resulting in an increased migratory capacity. During cancer progression, EMT is found to be...

  • Review
  • Open Access
250 Citations
17,352 Views
22 Pages

Endothelial to Mesenchymal Transition (EndoMT) in the Pathogenesis of Human Fibrotic Diseases

  • Sonsoles Piera-Velazquez,
  • Fabian A. Mendoza and
  • Sergio A. Jimenez

Fibrotic diseases encompass a wide spectrum of clinical entities including systemic fibrotic diseases such as systemic sclerosis, sclerodermatous graft versus host disease, nephrogenic systemic fibrosis, and IgG4-associated sclerosing disease, as wel...

  • Review
  • Open Access
31 Citations
8,924 Views
17 Pages

Epithelial–mesenchymal transition (EMT) and cell migration are important processes in embryonic development of many tissues as well as oncogenesis. The pituitary gland is a master endocrine tissue and recent studies indicate that Sox2-expressing stem...

  • Review
  • Open Access
288 Citations
19,455 Views
18 Pages

Epithelial-to-mesenchymal transition (EMT) is a key step in development, wound healing, and cancer development. It involves cooperation of signaling pathways, such as transformation growth factor-β (TGF-β), Sonic Hedgehog (SHH), and WNT pathways. The...

  • Review
  • Open Access
14 Citations
9,815 Views
10 Pages

The role of ω3 alpha linolenic acid (ALA) in the maternal diet during pregnancy and lactation, and its effect on the prevention of disease and programming of health in offspring, is largely unknown. Compared to ALA, ω3 docosahexaenoic (DHA) and eicos...

  • Review
  • Open Access
100 Citations
9,866 Views
16 Pages

Osteopontin—A Master Regulator of Epithelial-Mesenchymal Transition

  • Anai N. Kothari,
  • Matthew L. Arffa,
  • Victor Chang,
  • Robert H. Blackwell,
  • Wing-Kin Syn,
  • Jiwang Zhang,
  • Zhiyong Mi and
  • Paul C. Kuo

Osteopontin (OPN) plays an important functional role in both physiologic and pathologic states. OPN is implicated in the progression of fibrosis, cancer, and metastatic disease in several organ systems. The epithelial-mesenchymal transition (EMT), fi...

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J. Clin. Med. - ISSN 2077-0383