J. Clin. Med. 2016, 5(4), 48; https://doi.org/10.3390/jcm5040048
Long-Term Weight Change after Initiating Second-Generation Antidepressants
David Arterburn 1,†,*
, Tamar Sofer 2,†, Denise M. Boudreau 1,†, Andy Bogart 1,†, Emily O. Westbrook 1,†, Mary Kay Theis 1,†, Greg Simon 1,† and Sebastien Haneuse 3,†
, Tamar Sofer 2,†, Denise M. Boudreau 1,†, Andy Bogart 1,†, Emily O. Westbrook 1,†, Mary Kay Theis 1,†, Greg Simon 1,† and Sebastien Haneuse 3,†1
Group Health Research Institute, 1730 Minor Ave, Suite 1600, Seattle, WA 98101, USA
2
University of Washington, UW Tower, 15th Floor, 4333 Brooklyn Ave NE, Seattle, WA 98105, USA
3
Harvard T.H. Chan School of Public Health, 677 Huntington Ave, Boston, MA 02115, USA
†
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Academic Editor: Nuri B. Farber
Received: 31 December 2015 / Revised: 1 April 2016 / Accepted: 6 April 2016 / Published: 13 April 2016
Abstract
(1) Objective: To examine the relationship between the choice of second-generation antidepressant drug treatment and long-term weight change; (2) Methods: We conducted a retrospective cohort study to investigate the relationship between choice of antidepressant medication and weight change at two years among adult patients with a new antidepressant treatment episode between January, 2006 and October, 2009 in a large health system in Washington State. Medication use, encounters, diagnoses, height, and weight were collected from electronic databases. We modeled change in weight and BMI at two years after initiation of treatment using inverse probability weighted linear regression models that adjusted for potential confounders. Fluoxetine was the reference treatment; (3) Results: In intent-to-treat analyses, non-smokers who initiated bupropion treatment on average lost 7.1 lbs compared to fluoxetine users who were non-smokers (95% CI: −11.3, −2.8; p-value < 0.01); smokers who initiated bupropion treatment gained on average 2.2 lbs compared to fluoxetine users who were smokers (95% CI: −2.3, 6.8; p-value = 0.33). Changes in weight associated with all other antidepressant medications were not significantly different than fluoxetine, except for sertraline users, who gained an average of 5.9 lbs compared to fluoxetine users (95% CI: 0.8, 10.9; p-value = 0.02); (4) Conclusion: Antidepressant drug therapy is significantly associated with long-term weight change at two years. Bupropion may be considered as the first-line drug of choice for overweight and obese patients unless there are other existing contraindications. View Full-TextKeywords:
obesity; antidepressant; depression; adverse effects; weight gain
▼
Figures
Figure 1a
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).
Share & Cite This Article
MDPI and ACS Style
Arterburn, D.; Sofer, T.; Boudreau, D.M.; Bogart, A.; Westbrook, E.O.; Theis, M.K.; Simon, G.; Haneuse, S. Long-Term Weight Change after Initiating Second-Generation Antidepressants. J. Clin. Med. 2016, 5, 48.
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.
Related Articles
Article Metrics
Comments
[Return to top]
J. Clin. Med.
EISSN 2077-0383
Published by MDPI AG, Basel, Switzerland
RSS
E-Mail Table of Contents Alert