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Signal Transduction Pathways of EMT Induced by TGF-β, SHH, and WNT and Their Crosstalks

Department of Computational and Systems Biology, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15260, USA
Author to whom correspondence should be addressed.
Academic Editor: Jane Grant-Kels
J. Clin. Med. 2016, 5(4), 41;
Received: 20 November 2015 / Revised: 31 January 2016 / Accepted: 21 March 2016 / Published: 28 March 2016
(This article belongs to the Special Issue Epithelial-Mesenchymal Transition)
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Epithelial-to-mesenchymal transition (EMT) is a key step in development, wound healing, and cancer development. It involves cooperation of signaling pathways, such as transformation growth factor-β (TGF-β), Sonic Hedgehog (SHH), and WNT pathways. These signaling pathways crosstalk to each other and converge to key transcription factors (e.g., SNAIL1) to initialize and maintain the process of EMT. The functional roles of multi-signaling pathway crosstalks in EMT are sophisticated and, thus, remain to be explored. In this review, we focused on three major signal transduction pathways that promote or regulate EMT in carcinoma. We discussed the network structures, and provided a brief overview of the current therapy strategies and drug development targeted to these three signal transduction pathways. Finally, we highlighted systems biology approaches that can accelerate the process of deconstructing complex networks and drug discovery. View Full-Text
Keywords: signaling transduction pathways; EMT; TGF-β; SHH; WNT; modeling signaling transduction pathways; EMT; TGF-β; SHH; WNT; modeling

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Zhang, J.; Tian, X.-J.; Xing, J. Signal Transduction Pathways of EMT Induced by TGF-β, SHH, and WNT and Their Crosstalks. J. Clin. Med. 2016, 5, 41.

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