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EMT Involved in Migration of Stem/Progenitor Cells for Pituitary Development and Regeneration

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Organization for the Strategic Coordination of Research and Intellectual Property, Meiji University, Kanagawa 214-8571, Japan
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Institute of Reproduction and Endocrinology, Meiji University, Kanagawa 214-8571, Japan
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Division of Life Science, Graduate School of Agriculture, Meiji University, Kanagawa 214-8571, Japan
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Department of Life Science, School of Agriculture, Meiji University, Kanagawa 214-8571, Japan
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Author to whom correspondence should be addressed.
Academic Editors: David A. Brenner, Tatiana Kisseleva and Jonas Fuxe
J. Clin. Med. 2016, 5(4), 43; https://doi.org/10.3390/jcm5040043
Received: 4 December 2015 / Revised: 24 March 2016 / Accepted: 29 March 2016 / Published: 6 April 2016
(This article belongs to the Special Issue Epithelial-Mesenchymal Transition)
Epithelial–mesenchymal transition (EMT) and cell migration are important processes in embryonic development of many tissues as well as oncogenesis. The pituitary gland is a master endocrine tissue and recent studies indicate that Sox2-expressing stem/progenitor cells actively migrate and develop this tissue during embryogenesis. Notably, although migration activity of stem/progenitor cells in the postnatal period seems to be reduced compared to that in the embryonic period, it is hypothesized that stem/progenitor cells in the adult pituitary re-migrate from their microenvironment niche to contribute to the regeneration system. Therefore, elucidation of EMT in the pituitary stem/progenitor cells will promote understanding of pituitary development and regeneration, as well as diseases such as pituitary adenoma. In this review, so as to gain more insights into the mechanisms of pituitary development and regeneration, we summarize the EMT in the pituitary by focusing on the migration of pituitary stem/progenitor cells during both embryonic and postnatal organogenesis. View Full-Text
Keywords: pituitary development; stem/progenitor cell niche; cell regeneration; EMT; migration pituitary development; stem/progenitor cell niche; cell regeneration; EMT; migration
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MDPI and ACS Style

Yoshida, S.; Kato, T.; Kato, Y. EMT Involved in Migration of Stem/Progenitor Cells for Pituitary Development and Regeneration. J. Clin. Med. 2016, 5, 43.

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