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Journal of Clinical Medicine, Volume 10, Issue 12

2021 June-2 - 207 articles

Cover Story: Beyond the optimal management of the traditional Atherosclerotic cardiovascular diseases (ASCVD) risk factors, infections should be considered as an important non-classical risk factor to enable early diagnosis and appropriate treatment. We summarized the currently available evidence regarding the role of inflammation in ASCVD and the association between the particular infections and pathogens on the development and progression of ASCVD. We also speculated about the potential therapeutic implications of the anti-inflammatory and anti-infective drugs on ASCVD outcomes, including drugs routinely administered in patients with ASCVD and novel strategies aiming at residual risk reduction. Considering the emerging association between infections and ASCVD, it is crucial to determine the possible advantages of infection prevention and treatment in patients with ASCVD. View this paper
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Articles (207)

  • Article
  • Open Access
6 Citations
2,939 Views
11 Pages

In Vitro Development of a New Sponge-Based Delivery System for Intracanal Antimicrobial Administration in Endodontic Treatment

  • Ruíz-Piñón Manuel,
  • Gancedo-Gancedo Tania,
  • Seoane-Prado Rafael,
  • Pérez-Estévez Antonio,
  • Blanco-Méndez José,
  • Luzardo-Álvarez Asteria,
  • Castelo-Baz Pablo,
  • Lorenzo-Pouso Alejandro,
  • Álvarez-Novoa Pablo and
  • Martín-Biedma Benjamín

21 June 2021

This study aimed to evaluate the in vitro performance of collagen-based sponges as a drug delivery system for intracanal antimicrobial administration. Four groups of loaded collagen-based sponges (A, 0.3% w/v amoxicillin trihydrate: potassium clavula...

(This article belongs to the Section Dentistry, Oral Surgery and Oral Medicine)
  • Article
  • Open Access
16 Citations
3,138 Views
10 Pages

Therapeutic Efficacy of Autologous Platelet Concentrate Injection on Macular Holes with High Myopia, Large Macular Holes, or Recurrent Macular Holes: A Multicenter Randomized Controlled Trial

  • Mirinae Kim,
  • Jae-Yon Won,
  • Seung-Yong Choi,
  • Minhee Kim,
  • Ho Ra,
  • Donghyun Jee,
  • Jin-Woo Kwon,
  • Kui-Dong Kang,
  • Young-Jung Roh and
  • Young-Hoon Park
  • + 4 authors

21 June 2021

We aimed to evaluate the anatomical and functional outcomes of pars-plana vitrectomy (PPV) with or without autologous platelet concentrate (APC) injection in patients with recurrent macular holes (MHs), large MHs, or MHs with high myopia. This multic...

(This article belongs to the Section Ophthalmology)
  • Article
  • Open Access
12 Citations
2,953 Views
7 Pages

B-Type Natriuretic Peptides and High-Sensitive Troponin I as COVID-19 Survival Factors: Which One Is the Best Performer?

  • Renato de Falco,
  • Maria Vargas,
  • Daniela Palma,
  • Marcella Savoia,
  • Anna Miscioscia,
  • Biagio Pinchera,
  • Martina Vano,
  • Giuseppe Servillo,
  • Ivan Gentile and
  • Giuliana Fortunato

21 June 2021

Increased concentrations of B-type natriuretic peptide (BNP), N-terminal pro-B-type natriuretic peptide (NT-proBNP) and high-sensitivity troponin I (HsTnI) in COVID-19 patients have already been reported. The aim of this study is to evaluate which of...

(This article belongs to the Section Epidemiology & Public Health)
  • Article
  • Open Access
12 Citations
3,060 Views
6 Pages

21 June 2021

Antiphospholipid syndrome (APS) is associated with thrombotic events (tAPS) and/or obstetrical morbidity (oAPS), with persisting antiphospholipid antibodies (aPL). Despite an update of aPL in 2006, several patients had typical clinical events without...

(This article belongs to the Special Issue Management, Diagnosis and Pathophysiology of Antiphospholipid Syndrome: Current Updates and Future Approaches)
  • Article
  • Open Access
8 Citations
2,544 Views
13 Pages

21 June 2021

Early allograft dysfunction (EAD) is a postoperative complication that may cause graft failure and mortality after liver transplantation. The objective of this study was to examine whether the preoperative serum uric acid (SUA) level may predict EAD....

(This article belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
  • Article
  • Open Access
9 Citations
3,838 Views
8 Pages

Carboxyhemoglobinemia in Critically Ill Coronavirus Disease 2019 Patients

  • Hina Faisal,
  • Syeda T. Ali,
  • Jiaqiong Xu,
  • Tariq Nisar,
  • Mahmoud Sabawi,
  • Eric Salazar and
  • Faisal N. Masud

21 June 2021

Carboxyhemoglobinemia is a common but a serious disorder, defined as an increase in carboxyhemoglobin level. Unfortunately, there are few data on carboxyhemoglobinemia in coronavirus disease 2019 (COVID-19) patients. Therefore, our study aimed to eva...

(This article belongs to the Section Intensive Care)
  • Article
  • Open Access
14 Citations
3,582 Views
12 Pages

The Addition of Transarterial Chemoembolization to Palliative Chemotherapy Extends Survival in Intrahepatic Cholangiocarcinoma

  • Simon Johannes Gairing,
  • Felix Thol,
  • Lukas Müller,
  • Felix Hahn,
  • Thomas Thomaidis,
  • Carolin Czauderna,
  • Fabian Bartsch,
  • Michael Bernhard Pitton,
  • Jens Uwe Marquardt and
  • Friedrich Foerster
  • + 5 authors

21 June 2021

Incidence and mortality of intrahepatic cholangiocarcinoma (iCCA) have been increasing continuously. Recent studies suggest that the combination of palliative chemotherapy (pCTX) and transarterial chemoembolization (TACE) improves overall survival (O...

(This article belongs to the Special Issue Management of Intrahepatic Cholangiocarcinoma)
  • Review
  • Open Access
42 Citations
13,059 Views
15 Pages

Incidence of Fat Embolism Syndrome in Femur Fractures and Its Associated Risk Factors over Time—A Systematic Review

  • Maximilian Lempert,
  • Sascha Halvachizadeh,
  • Prasad Ellanti,
  • Roman Pfeifer,
  • Jakob Hax,
  • Kai O. Jensen and
  • Hans-Christoph Pape

21 June 2021

Background: Fat embolism (FE) continues to be mentioned as a substantial complication following acute femur fractures. The aim of this systematic review was to test the hypotheses that the incidence of fat embolism syndrome (FES) has decreased since...

(This article belongs to the Section Orthopedics)
  • Review
  • Open Access
15 Citations
7,294 Views
12 Pages

Erectile Dysfunction in Men with Chronic Obstructive Pulmonary Disease

  • Lorenzo Marinelli,
  • Fabio Lanfranco,
  • Giovanna Motta and
  • Marco Zavattaro

21 June 2021

Erectile dysfunction (ED) seems to be a widespread sexual issue in men affected by chronic obstructive pulmonary disease (COPD). Multiple causes appear to be involved such as hormonal imbalance, smoking habit, chronic inflammation, endothelial dysfun...

(This article belongs to the Special Issue Erectile Dysfunction in Men with Chronic Diseases: From Pathophysiology to Clinical Management)
  • Article
  • Open Access
20 Citations
7,371 Views
8 Pages

Evaluation of SARS-CoV-2 in the Vaginal Secretions of Women with COVID-19: A Prospective Study

  • Elad Barber,
  • Michal Kovo,
  • Sophia Leytes,
  • Ron Sagiv,
  • Eran Weiner,
  • Orna Schwartz,
  • Margarita Mashavi,
  • Keren Holtzman,
  • Jacob Bar and
  • Shimon Ginath
  • + 1 author

21 June 2021

Objective: We aimed to investigate the likelihood of vaginal colonization with Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in pregnant and non-pregnant women with Coronavrus Disease 2019 (COVID-19). Materials and Methods: Vaginal swa...

(This article belongs to the Special Issue COVID-19 and Pregnancy)
  • Article
  • Open Access
22 Citations
11,410 Views
12 Pages

Computed Tomography in Adults with Bronchiectasis and Nontuberculous Mycobacterial Pulmonary Disease: Typical Imaging Findings

  • Sabine Dettmer,
  • Felix C. Ringshausen,
  • Jan Fuge,
  • Hannah Louise Maske,
  • Tobias Welte,
  • Frank Wacker and
  • Jessica Rademacher

21 June 2021

Among patients with bronchiectasis, nontuberculous mycobacterial pulmonary disease (NTM-PD) ranged between 1 and 6% and it is suspected that its prevalence is underestimated. Our aim was to evaluate differences in computed tomography (CT) features in...

(This article belongs to the Special Issue Bronchiectasis in Adults: Aetiology and New Therapies)
  • Article
  • Open Access
3 Citations
4,159 Views
11 Pages

Corticosteroid Resistance in Smokers—A Substudy Analysis of the CORTICO-COP Randomised Controlled Trial

  • Pradeesh Sivapalan,
  • Andras Bikov,
  • Charlotte Suppli Ulrik,
  • Therese Sophie Lapperre,
  • Alexander G. Mathioudakis,
  • Mats Christian Højberg Lassen,
  • Kristoffer Grundtvig Skaarup,
  • Tor Biering-Sørensen,
  • Jørgen Vestbo and
  • Jens-Ulrik S. Jensen

21 June 2021

The CORTICO-COP trial showed that eosinophil-guided corticosteroid-sparing treatment for acute exacerbation of chronic obstructive pulmonary disease was non-inferior to standard of care and decreased the accumulated dose of systemic corticosteroids t...

(This article belongs to the Special Issue Current Perspectives in Management of Chronic Obstructive Pulmonary Disease)
  • Article
  • Open Access
14 Citations
4,803 Views
9 Pages

21 June 2021

European evidence-based guidelines for the treatment and management of chronic pancreatitis (CP) have been made available following the harmonizing diagnosis and treatment of CP across Europe (HaPanEU) initiative by the United European Gastroenterolo...

(This article belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
  • Review
  • Open Access
124 Citations
14,038 Views
13 Pages

Patient-Self Inflicted Lung Injury: A Practical Review

  • Guillaume Carteaux,
  • Mélodie Parfait,
  • Margot Combet,
  • Anne-Fleur Haudebourg,
  • Samuel Tuffet and
  • Armand Mekontso Dessap

21 June 2021

Patients with severe lung injury usually have a high respiratory drive, resulting in intense inspiratory effort that may even worsen lung damage by several mechanisms gathered under the name “patient-self inflicted lung injury” (P-SILI). Even though...

(This article belongs to the Special Issue Management of Acute Respiratory Failure)
  • Article
  • Open Access
11 Citations
4,009 Views
8 Pages

Hemoglobin A1c in Patients with Diabetes Predict Long-Term Mortality Following Coronary Artery Surgery

  • Muhammad Abu Tailakh,
  • Shlomo-yaron Ishay,
  • Jenan Awesat,
  • Liat Poupko,
  • Gidon Sahar and
  • Victor Novack

21 June 2021

Objective: to estimate the association between preoperative hemoglobin A1c (HbA1c) levels below and above 7%, and the rate of all-cause mortality (ACM) in diabetes mellitus (DM) patients after coronary artery bypass grafting (CABG) within a ten-year...

(This article belongs to the Collection Current Clinical Treatments and Challenges for Coronary Artery Disease (CAD))
  • Article
  • Open Access
27 Citations
5,824 Views
7 Pages

Risk Factors of Inadequate Bowel Preparation for Screening Colonoscopy

  • Efrat L. Amitay,
  • Tobias Niedermaier,
  • Anton Gies,
  • Michael Hoffmeister and
  • Hermann Brenner

21 June 2021

The success of a colonoscopy in detecting and removing pre-cancerous and cancerous lesions depends heavily on the quality of bowel preparation. Despite efforts, 20–44% of colonoscopy participants have an inadequate bowel preparation. We aimed to asse...

(This article belongs to the Special Issue Current and Emerging Technologies & Applications of Endoscopy in Clinical Practice)
  • Article
  • Open Access
19 Citations
5,834 Views
11 Pages

Rectus Femoris Mimicking Ultrasound Phantom for Muscle Mass Assessment: Design, Research, and Training Application

  • Nobuto Nakanishi,
  • Shigeaki Inoue,
  • Rie Tsutsumi,
  • Yusuke Akimoto,
  • Yuko Ono,
  • Joji Kotani,
  • Hiroshi Sakaue and
  • Jun Oto

20 June 2021

Ultrasound has become widely used as a means to measure the rectus femoris muscle in the acute and chronic phases of critical illness. Despite its noninvasiveness and accessibility, its accuracy highly depends on the skills of the technician. However...

(This article belongs to the Section Emergency Medicine)
  • Article
  • Open Access
16 Citations
5,894 Views
14 Pages

20 June 2021

Objectives: To evaluate the effect of clopidogrel vs. aspirin monotherapy on vascular function and hemostatic measurement. Background: Monotherapy with P2Y12 receptor inhibitor vs. aspirin can be a useful alterative to optimize clinical efficacy and...

(This article belongs to the Section Cardiology)
  • Review
  • Open Access
27 Citations
4,517 Views
12 Pages

Sitafloxacin for Third-Line Helicobacter pylori Eradication: A Systematic Review

  • Toshihiro Nishizawa,
  • Munkhbayar Munkjargal,
  • Hirotoshi Ebinuma,
  • Osamu Toyoshima and
  • Hidekazu Suzuki

20 June 2021

Background and Aim: Sitafloxacin-based therapy is a potent candidate for third-line Helicobacter pylori eradication treatment. In this systematic review, we summarise current reports with sitafloxacin-based therapy as a third-line treatment. Methods:...

(This article belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
  • Review
  • Open Access
18 Citations
6,345 Views
20 Pages

20 June 2021

Total pancreatectomy is a major complex surgical procedure involving removal of the whole pancreatic parenchyma and duodenum. It leads to lifelong pancreatic exocrine and endocrine insufficiency. The control of surgery-induced diabetes (type 3) requi...

(This article belongs to the Special Issue Islet Cell Transplantation for Treatment of Pancreatic Diseases)
  • Article
  • Open Access
7 Citations
4,180 Views
12 Pages

Bariatric Surgery Affects Plasma Levels of Alanine Aminotransferase Independent of Weight Loss: A Registry-Based Study

  • Shira Azulai,
  • Ronit Grinbaum,
  • Nahum Beglaibter,
  • Shai Meron Eldar,
  • Moshe Rubin,
  • Shai Carmi,
  • Rachel Ben-Haroush Schyr,
  • Orly Romano-Zelekha and
  • Danny Ben-Zvi

20 June 2021

Patients that undergo bariatric surgery experience weight loss and a reduction in the plasma levels of the hepatic enzymes alanine aminotransferase (ALT) and aspartate aminotransferase (AST). We used the Israeli national bariatric registry, which inc...

(This article belongs to the Section Endocrinology & Metabolism)
  • Review
  • Open Access
42 Citations
9,831 Views
22 Pages

Effectiveness of Acceptance and Commitment Therapy in Central Pain Sensitization Syndromes: A Systematic Review

  • Carmen M. Galvez-Sánchez,
  • Casandra I. Montoro,
  • María Moreno-Padilla,
  • Gustavo A. Reyes del Paso and
  • Pablo de la Coba

19 June 2021

Objectives: Acceptance and commitment therapy (ACT) is considered by the American Psychological Association as an evidence-based treatment for a variety of disorders, including chronic pain. The main objective of the present systematic review was to...

(This article belongs to the Special Issue New Advances in Cognitive and Behavior Psychotherapies)
  • Article
  • Open Access
53 Citations
6,048 Views
14 Pages

Patterns of Oral Microbiota in Patients with Apical Periodontitis

  • Izabela Korona-Glowniak,
  • Dominika Piatek,
  • Emilia Fornal,
  • Anna Lukowiak,
  • Yuriy Gerasymchuk,
  • Anna Kedziora,
  • Gabriela Bugla-Płoskonska,
  • Ewelina Grywalska,
  • Teresa Bachanek and
  • Anna Malm

19 June 2021

In this study, microbial diversity of the root canal microbiota related to different endodontic infections was investigated. In total, 45 patients with endo–perio lesions (8 patients), chronic periapical periodontitis (29 patients) and pulp necrosis...

(This article belongs to the Special Issue Root Canal Treatment (RCT): Latest Advances and Prospects)
  • Article
  • Open Access
8 Citations
2,697 Views
10 Pages

Evaluating the Prognostic Value of Islet Autoantibody Monitoring in Islet Transplant Recipients with Long-Standing Type 1 Diabetes Mellitus

  • Roi Anteby,
  • Aaron Lucander,
  • Piotr J. Bachul,
  • Jordan Pyda,
  • Damian Grybowski,
  • Lindsay Basto,
  • Gabriela S. Generette,
  • Laurencia Perea,
  • Karolina Golab and
  • Piotr Witkowski
  • + 4 authors

19 June 2021

(1) Background: The correlation between titers of islet autoantibodies (IAbs) and the loss of transplanted islets remains controversial. We sought to evaluate the prognostic utility of monitoring IAbs in diabetic patients after islet transplantation...

(This article belongs to the Special Issue Islet Cell Transplantation for Treatment of Pancreatic Diseases)
  • Article
  • Open Access
10 Citations
2,887 Views
9 Pages

The Use of Virtual Reality to Reduce Stress among Inflammatory Bowel Disease Patients Treated with Vedolizumab

  • Konrad Lewandowski,
  • Magdalena Kaniewska,
  • Mariusz Rosołowski,
  • Piotr Kucha and
  • Grażyna Rydzewska

19 June 2021

(1) Background: The use of virtual reality (VR) in improving patient comfort related to medical procedures in oncology patients raised the question of whether similar benefits could be obtained by patients with inflammatory bowel disease (IBD). (2) M...

(This article belongs to the Special Issue Advances in Inflammatory Bowel Disease)
  • Article
  • Open Access
20 Citations
4,464 Views
18 Pages

Phenotypic Features and Genetic Findings in a Cohort of Italian Pseudoxanthoma Elasticum Patients and Update of the Ophthalmologic Evaluation Score

  • Federica Boraldi,
  • Vittoria Murro,
  • Francesco Demetrio Lofaro,
  • Dario Pasquale Mucciolo,
  • Sonia Costa,
  • Laura Pavese and
  • Daniela Quaglino

19 June 2021

Background: Pseudoxanthoma elasticum (PXE) is a rare ectopic calcification genetic disease mainly caused by ABCC6 rare sequence variants. The clinical phenotype is characterized by typical dermatological, ophthalmological and cardiovascular manifesta...

(This article belongs to the Special Issue Pseudoxanthoma Elasticum Pathophysiology, from Clinic to Bench Side)
  • Review
  • Open Access
23 Citations
9,650 Views
17 Pages

Pancreatic Ductal Adenocarcinoma: Relating Biomechanics and Prognosis

  • Benjamin M. MacCurtain,
  • Ned P. Quirke,
  • Stephen D. Thorpe and
  • Tom K. Gallagher

19 June 2021

Pancreatic ductal adenocarcinoma (PDAC) is the most common form of pancreatic cancer and carries a dismal prognosis. Resectable patients are treated predominantly with surgery while borderline resectable patients may receive neoadjuvant treatment (NA...

(This article belongs to the Special Issue Pancreatic Cancer: Challenges and Breakthroughs)
  • Article
  • Open Access
18 Citations
7,899 Views
9 Pages

19 June 2021

Background: Odontogenic sinusitis (ODS) is frequently encountered in ENT practice; however, there are no guidelines regarding its management. This study aims to analyse the results of endoscopic sinus surgery versus dental treatment in ODS. Additiona...

(This article belongs to the Section Otolaryngology)
  • Review
  • Open Access
13 Citations
9,813 Views
13 Pages

Safety and Efficacy of SGLT2 Inhibitors: A Multiple-Treatment Meta-Analysis of Clinical Decision Indicators

  • Vicente Martínez-Vizcaíno,
  • Ana Díez-Fernández,
  • Celia Álvarez-Bueno,
  • Julia Martínez-Alfonso and
  • Iván Cavero-Redondo

19 June 2021

To jointly assess the safety and effectiveness of sodium-glucose cotransporter 2 inhibitors (SGLT2i) on cardiorenal outcomes and all-cause mortality in type 2 diabetes mellitus (T2DM) with or at high risk of cardiovascular disease (CVD). We performed...

(This article belongs to the Section Pharmacology)
  • Article
  • Open Access
4 Citations
5,822 Views
15 Pages

Altered Cardiovascular Reactivity to and Recovery from Cold Face Test-Induced Parasympathetic Stimulation in Essential Hypertension

  • Lisa-Marie Walther,
  • Roland von Känel,
  • Nadja Heimgartner,
  • Claudia Zuccarella-Hackl,
  • Ulrike Ehlert and
  • Petra H. Wirtz

19 June 2021

Essential hypertension is associated with increased sympathetic and diminished parasympathetic activity as well as impaired reactivity to sympathetic stimulation. However, reactivity and recovery from parasympathetic stimulation in hypertension are u...

(This article belongs to the Special Issue Effects of Stress and Psychological Trauma on the Development and Progression of Cardiovascular Diseases)
  • Article
  • Open Access
9 Citations
3,863 Views
18 Pages

Chemokine/Cytokine Levels Correlate with Organ Involvement in PR3-ANCA-Associated Vasculitis

  • Janina Müller-Deile,
  • Christian Jaremenko,
  • Hermann Haller,
  • Mario Schiffer,
  • Marion Haubitz,
  • Silke Christiansen,
  • Christine Falk and
  • Lena Schiffer

19 June 2021

Background: ANCA-associated vasculitis (AAV) is a rare small vessel disease characterized by multi-organ involvement. Biomarkers that can measure specific organ involvement are missing. Here, we ask whether certain circulating cytokines and chemokine...

(This article belongs to the Section Vascular Medicine)
  • Article
  • Open Access
10 Citations
6,337 Views
12 Pages

Long-Term Effectiveness and Safety of Tafluprost, Travoprost, and Latanoprost in Korean Patients with Primary Open-Angle Glaucoma or Normal-Tension Glaucoma: A Multicenter Retrospective Cohort Study (LOTUS Study)

  • Joon-Mo Kim,
  • Kyung-Rim Sung,
  • Hwang-Ki Kim,
  • Sang-Woo Park,
  • Eun-Ji Lee,
  • Jin-Wook Jeoung,
  • Hae-Young Lopilly Park,
  • Jaehong Ahn,
  • Chungkwon Yoo and
  • Chan-Yun Kim

19 June 2021

This multicenter retrospective cohort study compared the effectiveness and safety of long-term tafluprost, travoprost, or latanoprost in patients with primary open-angle glaucoma (POAG) or normal-tension glaucoma (NTG). Data were extracted from elect...

(This article belongs to the Section Ophthalmology)
  • Article
  • Open Access
6 Citations
3,424 Views
8 Pages

Realistic Advantages of Early Surgical Drain Removal after Pancreatoduodenectomy: A Single-Institution Retrospective Study

  • So-Jeong Yoon,
  • So-Kyung Yoon,
  • Ji-Hye Jung,
  • In-Woong Han,
  • Dong-Wook Choi,
  • Jin-Seok Heo and
  • Sang-Hyun Shin

19 June 2021

The latest guidelines from the Enhanced Recovery After Surgery (ERAS®) Society stated that early drain removal after pancreatoduodenectomy (PD) is beneficial in decreasing complications including postoperative pancreatic fistulas (POPFs). This study...

(This article belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
  • Article
  • Open Access
6 Citations
2,751 Views
12 Pages

Increased Serum Levels of Activated Caspases in Murine and Human Biliary Atresia

  • Omid Madadi-Sanjani,
  • Gunnar Bohlen,
  • Fabian Wehrmann,
  • Julia Andruszkow,
  • Karim Khelif,
  • Reinhard von Wasielewski,
  • Heike Bantel and
  • Claus Petersen

19 June 2021

In biliary atresia (BA), apoptosis is part of the pathomechanism, which results in progressive liver fibrosis. There is increasing evidence suggesting that apoptotic liver injury can be non-invasively detected by measuring the caspase activity in the...

(This article belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
  • Article
  • Open Access
15 Citations
4,344 Views
20 Pages

Impact of Bundle Branch Block on Permanent Pacemaker Implantation after Transcatheter Aortic Valve Implantation: A Meta-Analysis

  • Justine M. Ravaux,
  • Michele Di Mauro,
  • Kevin Vernooy,
  • Silvia Mariani,
  • Daniele Ronco,
  • Jorik Simons,
  • Arnoud W. Van't Hof,
  • Leo Veenstra,
  • Suzanne Kats and
  • Roberto Lorusso
  • + 1 author

19 June 2021

Data regarding the impact of infra-Hisian conduction disturbances leading to permanent pacemaker implantation (PPI) after transcatheter aortic valve implantation (TAVI) remain limited. The aim of this study was to determine the impact of right and/or...

(This article belongs to the Special Issue Advances in the Management of Cardiovascular Disease)
  • Article
  • Open Access
14 Citations
3,526 Views
21 Pages

Methylation Status of Corticotropin-Releasing Factor (CRF) Receptor Genes in Colorectal Cancer

  • Maria Panagopoulou,
  • Antonia Cheretaki,
  • Makrina Karaglani,
  • Ioanna Balgkouranidou,
  • Eirini Biziota,
  • Kyriakos Amarantidis,
  • Nikolaos Xenidis,
  • Stylianos Kakolyris,
  • Stavroula Baritaki and
  • Ekaterini Chatzaki

18 June 2021

The corticotropin-releasing factor (CRF) system has been strongly associated with gastrointestinal pathophysiology, including colorectal cancer (CRC). We previously showed that altered expression of CRF receptors (CRFRs) in the colon critically affec...

(This article belongs to the Special Issue Novel Biomarkers and Therapeutic Targets for Human Cancers)
  • Article
  • Open Access
13 Citations
3,086 Views
10 Pages

18 June 2021

Computer-assisted analysis is expected to improve the reliability of videofluoroscopic swallowing studies (VFSSs), but its usefulness is limited. Previously, we proposed a deep learning model that can detect laryngeal penetration or aspiration fully...

(This article belongs to the Special Issue Advances in Management of Voice and Swallowing Disorders)
  • Article
  • Open Access
21 Citations
4,507 Views
13 Pages

18 June 2021

Background: Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is a small vessel vasculitis, most frequently presenting as microscopic polyangiitis (MPA) or granulomatosis with polyangiitis (GPA). Acute tubular injury with the pre...

(This article belongs to the Special Issue The New Therapeutic Targets in Acute Kidney Injury)
  • Article
  • Open Access
8 Citations
3,820 Views
10 Pages

The CRBN, CUL4A and DDB1 Expression Predicts the Response to Immunomodulatory Drugs and Survival of Multiple Myeloma Patients

  • Joanna Barankiewicz,
  • Anna Szumera-Ciećkiewicz,
  • Aleksander Salomon-Perzyński,
  • Paulina Wieszczy,
  • Agata Malenda,
  • Filip Garbicz,
  • Monika Prochorec-Sobieszek,
  • Irena Misiewicz-Krzemińska,
  • Przemysław Juszczyński and
  • Ewa Lech-Marańda

18 June 2021

Immunomodulatory drugs (IMiDs) are effective in the treatment of multiple myeloma (MM), myelodysplastic syndrome with deletion of chromosome 5q and other haematological malignancies. Recent studies showed that IMiDs bind to cereblon (CRBN), a substra...

(This article belongs to the Section Oncology)
  • Article
  • Open Access
9 Citations
3,035 Views
6 Pages

A Retrospective Study of Herpetic Keratitis in Patients with Keratoconus after Crosslinking Surgery

  • Ewa Wróblewska-Czajka,
  • Anna Nowińska,
  • Dariusz Dobrowolski,
  • Dominika Szkodny and
  • Edward Wylęgała

18 June 2021

Background: The aim of this study was to perform a retrospective analysis of patients who underwent cross-linking for keratoconus, in the Department of Ophthalmology of the Medical University of Silesia in Katowice, between 2011 and 2020, regarding t...

(This article belongs to the Special Issue Novel Medical Approach to Diagnostic and Therapeutic Algorithms in Ophthalmology)
  • Article
  • Open Access
6 Citations
3,504 Views
18 Pages

Validation of the Center of Applied Psychology Female Sexuality Questionnaire (CAPFS-Q)

  • Sonia Tirado-González,
  • Antonio Navarro-Sánchez,
  • Antonio Compañ-Rosique,
  • Paloma Luri-Prieto,
  • Jesús Rodríguez-Marín,
  • Carlos J. Van-der Hofstadt-Román,
  • María Berenguer Soler,
  • Felipe Navarro-Cremades,
  • Vicente F. Gil-Guillén and
  • Virtudes Pérez-Jover
  • + 2 authors

18 June 2021

Instruments for the measurement of human sexuality include self-report measures used to assess sexual functioning, but many of them have not yet been validated. The Center of Applied Psychology Female Sexual Questionnaire (CAPFS-Q) is an original sel...

(This article belongs to the Special Issue Sexuality and Sexual Dysfunctions)
  • Article
  • Open Access
8 Citations
3,131 Views
9 Pages

18 June 2021

Olfactory neuroblastoma (ONB) is a rare neuroepithelial-derived malignancy that usually presents in the nasal cavity. The rarity of ONB has led to conflicting reports regarding associations of patient age and ONB survival and outcome. Moreover, long-...

(This article belongs to the Section Oncology)
  • Review
  • Open Access
24 Citations
8,426 Views
31 Pages

18 June 2021

Retrieving spermatozoa from the testicles has been a great hope for patients with non-obstructive azoospermia (NOA), but relevant methods have not yet been developed to the level necessary to provide resolutions for all cases of NOA. Although perform...

(This article belongs to the Special Issue Update on the Management of Non-Obstructive Azoospermia: Current Evidence and Unmet Needs)
  • Article
  • Open Access
15 Citations
4,276 Views
10 Pages

Polycystic Ovary Syndrome Susceptibility Loci Inform Disease Etiological Heterogeneity

  • Yanfei Zhang,
  • Vani C. Movva,
  • Marc S. Williams and
  • Ming Ta Michael Lee

18 June 2021

Polycystic ovary syndrome (PCOS) is a complex disorder with heterogenous phenotypes and unclear etiology. A recent phenotypic clustering study identified metabolic and reproductive subtypes of PCOS. We hypothesize that the heterogeneity of PCOS manif...

(This article belongs to the Section Obstetrics & Gynecology)
  • Review
  • Open Access
72 Citations
6,772 Views
14 Pages

Obesity and Multiple Sclerosis—A Multifaceted Association

  • Thomas-Gabriel Schreiner and
  • Tudor-Marcel Genes

18 June 2021

Background: Given the common elements in the pathophysiological theories that try to explain the appearance and evolution of obesity and multiple sclerosis, the association between the two pathologies has become an increasingly researched topic in re...

(This article belongs to the Special Issue Clinical Advances in Multiple Sclerosis)
  • Article
  • Open Access
11 Citations
3,222 Views
7 Pages

Interest of Follow-Up Radiological Imaging in Patients with Pyogenic Vertebral Osteomyelitis

  • Sophie Hecquet,
  • Frank Verhoeven,
  • Sébastien Aubry,
  • Clément Prati,
  • Daniel Wendling,
  • Catherine Chirouze and
  • Kévin Bouiller

18 June 2021

No recommendations are established for monitoring pyogenic vertebral osteomyelitis (PVO). Thus, the realization of systematic follow-up radiological imaging is controversial. The objective of this study was to evaluate the interest in follow-up radio...

(This article belongs to the Section Orthopedics)
  • Article
  • Open Access
5 Citations
3,787 Views
11 Pages

Characteristics, Location, and Clinical Outcomes of Gastrointestinal Bleeding in Patients Taking New Oral Anticoagulants Compared to Vitamin K Antagonists

  • A Reum Choe,
  • Chang Mo Moon,
  • Chung Hyun Tae,
  • Jaeyoung Chun,
  • Ki Bae Bang,
  • Yoo Jin Lee,
  • Hyun Seok Lee,
  • Yunho Jung,
  • Sung Chul Park and
  • Hoon Sup Koo

18 June 2021

New oral anticoagulants (NOACs) are commonly used in clinical practice as alternatives to vitamin K antagonists (VKA). However, the etiology, clinical course, and risk of gastrointestinal (GI) bleeding remain unclear. We aimed to evaluate the clinica...

(This article belongs to the Special Issue Gastrointestinal Tract Disorders)
  • Article
  • Open Access
6 Citations
2,745 Views
15 Pages

Predictors of Early-Recurrence Atrial Fibrillation after Catheter Ablation in Women and Men with Abnormal Body Weight

  • Jan Budzianowski,
  • Jarosław Hiczkiewicz,
  • Katarzyna Łojewska,
  • Edyta Kawka,
  • Rafał Rutkowski and
  • Katarzyna Korybalska

18 June 2021

Our study aimed to select factors that affect the rate of early recurrence (up to 3 months) of atrial fibrillation (AF) (ERAF) following pulmonary veins isolation (PVI) in obese women and men. The study comprised 114 patients: 54 women (age: 63.8 ± 6...

(This article belongs to the Special Issue Advances in the Management of Cardiovascular Disease)
  • Article
  • Open Access
43 Citations
6,094 Views
7 Pages

18 June 2021

(1) Background: Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) excretion in stools is well documented by RT-PCR, but evidences that stools contain infectious particles are scarce. (2) Methods: After observing a Corona Virus 2019 Disease...

(This article belongs to the Special Issue Global Public Health in COVID-19: Pandemic Research from University Hospital Institute Méditerranée Infection)
  • Review
  • Open Access
53 Citations
7,903 Views
17 Pages

18 June 2021

The pathophysiology of asthma has been intensively studied, but its underlying mechanisms such as airway inflammation, control of airway tone, and bronchial reactivity are still not completely explained. There is an urgent need to implement novel, no...

(This article belongs to the Section Respiratory Medicine)

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J. Clin. Med. - ISSN 2077-0383