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Article

Therapeutic Efficacy of Autologous Platelet Concentrate Injection on Macular Holes with High Myopia, Large Macular Holes, or Recurrent Macular Holes: A Multicenter Randomized Controlled Trial

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Department of Ophthalmology and Visual Science, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul 06591, Korea
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Department of Ophthalmology and Visual Science, Eunpyeong St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul 03312, Korea
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Department of Ophthalmology, Dankook University Hospital, Dankook University College of Medicine, Cheonan 31116, Korea
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Department of Ophthalmology and Visual Science, Yeoido St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul 07345, Korea
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Department of Ophthalmology and Visual Science, Bucheon St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Bucheon 14647, Korea
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Department of Ophthalmology and Visual Science, St. Vincent’s Hospital, College of Medicine, The Catholic University of Korea, Suwon 16247, Korea
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Department of Ophthalmology and Visual Science, Incheon St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Incheon 21431, Korea
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Department of Ophthalmology and Visual Science, Daejeon St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Daejeon 34943, Korea
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Department of Preventive Medicine, College of Medicine, The Catholic University of Korea, Seoul 06591, Korea
*
Author to whom correspondence should be addressed.
Academic Editors: Michele Lanza and Tunde Peto
J. Clin. Med. 2021, 10(12), 2727; https://doi.org/10.3390/jcm10122727
Received: 16 May 2021 / Revised: 7 June 2021 / Accepted: 17 June 2021 / Published: 21 June 2021
(This article belongs to the Section Ophthalmology)
We aimed to evaluate the anatomical and functional outcomes of pars-plana vitrectomy (PPV) with or without autologous platelet concentrate (APC) injection in patients with recurrent macular holes (MHs), large MHs, or MHs with high myopia. This multicenter, prospective, interventional randomized controlled trial was conducted from March 2017 to April 2020. Participants were randomly allocated to a PPV group or a PPV+APC group. All participants underwent standard 25-gauge PPV, and eyes in the PPV+APC group underwent PPV with intravitreal APC injection before air-gas exchange. A total of 117 patients were enrolled (PPV group: n = 59, PPV+APC group: n = 58). Hole closure was achieved in 47 participants (79.7%) in the PPV group and 52 participants (89.7%) in the PPV+APC group. There were no between-group differences in the anatomical closure rate or functional outcomes including best-corrected visual acuity, metamorphopsia, pattern-reversal visual evoked potential, or Visual Function Questionnaire-25 score. The use of APC injection does not improve the anatomical and functional outcomes of surgery for large MHs, recurrent MHs, or MHs with high myopia. The adjunctive use of APC can be considered in selected cases because it is not inferior to conventional MH surgery, is relatively simple to perform, and is not affected by the surgeon’s skill. View Full-Text
Keywords: autologous platelet concentration; macular hole; pars plana vitrectomy autologous platelet concentration; macular hole; pars plana vitrectomy
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MDPI and ACS Style

Kim, M.; Won, J.-Y.; Choi, S.-Y.; Kim, M.; Ra, H.; Jee, D.; Kwon, J.-W.; Kang, K.-D.; Roh, Y.-J.; Park, Y.-G.; Kang, S.; Shin, J.-A.; Yim, H.-W.; Park, Y.-H. Therapeutic Efficacy of Autologous Platelet Concentrate Injection on Macular Holes with High Myopia, Large Macular Holes, or Recurrent Macular Holes: A Multicenter Randomized Controlled Trial. J. Clin. Med. 2021, 10, 2727. https://doi.org/10.3390/jcm10122727

AMA Style

Kim M, Won J-Y, Choi S-Y, Kim M, Ra H, Jee D, Kwon J-W, Kang K-D, Roh Y-J, Park Y-G, Kang S, Shin J-A, Yim H-W, Park Y-H. Therapeutic Efficacy of Autologous Platelet Concentrate Injection on Macular Holes with High Myopia, Large Macular Holes, or Recurrent Macular Holes: A Multicenter Randomized Controlled Trial. Journal of Clinical Medicine. 2021; 10(12):2727. https://doi.org/10.3390/jcm10122727

Chicago/Turabian Style

Kim, Mirinae, Jae-Yon Won, Seung-Yong Choi, Minhee Kim, Ho Ra, Donghyun Jee, Jin-Woo Kwon, Kui-Dong Kang, Young-Jung Roh, Young-Gun Park, Seungbum Kang, Jeong-Ah Shin, Hyeon-Woo Yim, and Young-Hoon Park. 2021. "Therapeutic Efficacy of Autologous Platelet Concentrate Injection on Macular Holes with High Myopia, Large Macular Holes, or Recurrent Macular Holes: A Multicenter Randomized Controlled Trial" Journal of Clinical Medicine 10, no. 12: 2727. https://doi.org/10.3390/jcm10122727

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