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Article

Evaluation of SARS-CoV-2 in the Vaginal Secretions of Women with COVID-19: A Prospective Study

1
Wolfson Medical Center, Department of Obstetrics & Gynecology, E. Holon 5822012, Israel
2
Sackler School of Medicine, Tel Aviv University, Tel Aviv 69978, Israel
3
Wolfson Medical Center, Microbiology Laboratory, E. Holon 5822012, Israel
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Wolfson Medical Center, Department of Internal Medicine “D,” E. Holon 5822012, Israel
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Wolfson Medical Center, Department of Medical Administration, E. Holon 5822012, Israel
*
Author to whom correspondence should be addressed.
Academic Editor: Yoav Yinon
J. Clin. Med. 2021, 10(12), 2735; https://doi.org/10.3390/jcm10122735
Received: 31 March 2021 / Revised: 12 June 2021 / Accepted: 16 June 2021 / Published: 21 June 2021
(This article belongs to the Special Issue COVID-19 and Pregnancy)
Objective: We aimed to investigate the likelihood of vaginal colonization with Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in pregnant and non-pregnant women with Coronavrus Disease 2019 (COVID-19). Materials and Methods: Vaginal swabs were taken from women diagnosed with mild to moderately acute SARS-CoV-2 infection, at Wolfson Medical Center, Israel, from March 2020 through October 2020. COVID-19 was diagnosed by real-time polymerase chain reaction (RT-PCR) performed on nasopharyngeal swabs. Vaginal swabs were tested for the presence of SARS-CoV-2 by reverse transcription polymerase chain reaction (RT-PCR). Results: In total, 51 women diagnosed with COVID-19 were included in the study. Of the 51 women with COVID-19 enrolled in this study, 16 (31.4%) were pregnant at enrollment and 35 (68.6%) were non-pregnant. Mean age was 43.5 ± 15.3 years (range 21–74 years). Compared to the non-pregnant group, the pregnant group was characterized by a higher white blood cell and absolute neutrophil count (p = 0.02 and p = 0.027, respectively). The non-pregnant patients were more likely to have chronic diseases (p = 0.035) and to be hospitalized (p < 0.001). Only one patient (1.9%) aged 60 years tested positive for SARS-CoV-2 in vaginal secretions. Mean gestational age at the diagnosis of COVID-19 of the pregnant group was 32.3 ± 7.8 weeks. Thirteen patients delivered during the study period; all delivered at term without obstetric complications and all neonates were healthy. Conclusions: Detection of SARS-CoV-2 in the vaginal secretions of patients diagnosed with COVID-19 is rare. Vaginal colonization may occur during the viremia phase of the disease, although infectivity from vaginal colonization needs to be proven. View Full-Text
Keywords: COVID-19; SARS-CoV-2; vaginal secretions COVID-19; SARS-CoV-2; vaginal secretions
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MDPI and ACS Style

Barber, E.; Kovo, M.; Leytes, S.; Sagiv, R.; Weiner, E.; Schwartz, O.; Mashavi, M.; Holtzman, K.; Bar, J.; Engel, A.; Ginath, S. Evaluation of SARS-CoV-2 in the Vaginal Secretions of Women with COVID-19: A Prospective Study. J. Clin. Med. 2021, 10, 2735. https://doi.org/10.3390/jcm10122735

AMA Style

Barber E, Kovo M, Leytes S, Sagiv R, Weiner E, Schwartz O, Mashavi M, Holtzman K, Bar J, Engel A, Ginath S. Evaluation of SARS-CoV-2 in the Vaginal Secretions of Women with COVID-19: A Prospective Study. Journal of Clinical Medicine. 2021; 10(12):2735. https://doi.org/10.3390/jcm10122735

Chicago/Turabian Style

Barber, Elad, Michal Kovo, Sophia Leytes, Ron Sagiv, Eran Weiner, Orna Schwartz, Margarita Mashavi, Keren Holtzman, Jacob Bar, Anat Engel, and Shimon Ginath. 2021. "Evaluation of SARS-CoV-2 in the Vaginal Secretions of Women with COVID-19: A Prospective Study" Journal of Clinical Medicine 10, no. 12: 2735. https://doi.org/10.3390/jcm10122735

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