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Fetal and Perinatal Outcome Following First and Second Trimester COVID-19 Infection: Evidence from a Prospective Cohort Study

Evaluation of SARS-CoV-2 in the Vaginal Secretions of Women with COVID-19: A Prospective Study

Wolfson Medical Center, Department of Obstetrics & Gynecology, E. Holon 5822012, Israel
Sackler School of Medicine, Tel Aviv University, Tel Aviv 69978, Israel
Wolfson Medical Center, Microbiology Laboratory, E. Holon 5822012, Israel
Wolfson Medical Center, Department of Internal Medicine “D,” E. Holon 5822012, Israel
Wolfson Medical Center, Department of Medical Administration, E. Holon 5822012, Israel
Author to whom correspondence should be addressed.
Academic Editor: Yoav Yinon
J. Clin. Med. 2021, 10(12), 2735;
Received: 31 March 2021 / Revised: 12 June 2021 / Accepted: 16 June 2021 / Published: 21 June 2021
(This article belongs to the Special Issue COVID-19 and Pregnancy)
Objective: We aimed to investigate the likelihood of vaginal colonization with Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in pregnant and non-pregnant women with Coronavrus Disease 2019 (COVID-19). Materials and Methods: Vaginal swabs were taken from women diagnosed with mild to moderately acute SARS-CoV-2 infection, at Wolfson Medical Center, Israel, from March 2020 through October 2020. COVID-19 was diagnosed by real-time polymerase chain reaction (RT-PCR) performed on nasopharyngeal swabs. Vaginal swabs were tested for the presence of SARS-CoV-2 by reverse transcription polymerase chain reaction (RT-PCR). Results: In total, 51 women diagnosed with COVID-19 were included in the study. Of the 51 women with COVID-19 enrolled in this study, 16 (31.4%) were pregnant at enrollment and 35 (68.6%) were non-pregnant. Mean age was 43.5 ± 15.3 years (range 21–74 years). Compared to the non-pregnant group, the pregnant group was characterized by a higher white blood cell and absolute neutrophil count (p = 0.02 and p = 0.027, respectively). The non-pregnant patients were more likely to have chronic diseases (p = 0.035) and to be hospitalized (p < 0.001). Only one patient (1.9%) aged 60 years tested positive for SARS-CoV-2 in vaginal secretions. Mean gestational age at the diagnosis of COVID-19 of the pregnant group was 32.3 ± 7.8 weeks. Thirteen patients delivered during the study period; all delivered at term without obstetric complications and all neonates were healthy. Conclusions: Detection of SARS-CoV-2 in the vaginal secretions of patients diagnosed with COVID-19 is rare. Vaginal colonization may occur during the viremia phase of the disease, although infectivity from vaginal colonization needs to be proven. View Full-Text
Keywords: COVID-19; SARS-CoV-2; vaginal secretions COVID-19; SARS-CoV-2; vaginal secretions
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MDPI and ACS Style

Barber, E.; Kovo, M.; Leytes, S.; Sagiv, R.; Weiner, E.; Schwartz, O.; Mashavi, M.; Holtzman, K.; Bar, J.; Engel, A.; Ginath, S. Evaluation of SARS-CoV-2 in the Vaginal Secretions of Women with COVID-19: A Prospective Study. J. Clin. Med. 2021, 10, 2735.

AMA Style

Barber E, Kovo M, Leytes S, Sagiv R, Weiner E, Schwartz O, Mashavi M, Holtzman K, Bar J, Engel A, Ginath S. Evaluation of SARS-CoV-2 in the Vaginal Secretions of Women with COVID-19: A Prospective Study. Journal of Clinical Medicine. 2021; 10(12):2735.

Chicago/Turabian Style

Barber, Elad, Michal Kovo, Sophia Leytes, Ron Sagiv, Eran Weiner, Orna Schwartz, Margarita Mashavi, Keren Holtzman, Jacob Bar, Anat Engel, and Shimon Ginath. 2021. "Evaluation of SARS-CoV-2 in the Vaginal Secretions of Women with COVID-19: A Prospective Study" Journal of Clinical Medicine 10, no. 12: 2735.

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