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Vaccines, Volume 11, Issue 12
December 2023 - 134 articles
Cover Story: The efficacy of primary vaccination, boosters, and Omicron-adapted mRNA vaccines in preventing severe SARS-CoV-2 infections, hospitalizations, and deaths has been well established. However, long-term follow up data on the immune response following repeated SARS-CoV-2 vaccinations are limited. In previously infected individuals, the immune response could be affected by immune imprinting. Waning immunity after vaccination and the emergence of immune-evading variants results in breakthrough infections; the repeated exposure of vaccinated individuals to SARS-CoV-2 antigens through breakthrough infections and/or additional vaccines could modulate the immune response against the antigenic RBD domain of new variants through hybrid immune damping. This Vaccines issue publishes long-term analyses of humoral and T cell responses in healthy adults receiving multiple SARS-CoV-2 mRNA vaccines. View this paper
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Vaccines - ISSN 2076-393X