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Vaccines, Volume 12, Issue 5

May 2024 - 116 articles

Cover Story: This study demonstrates that chronic opioid intake upregulates a distinct profile of plasma TNF superfamily (SF) molecules that are associated with immune cell interactions between Dendritic cells and T and B cells, which are important for antibody responses. In a study of people with HIV (PWH), those with associated opioid use disorder (OUD) exhibited higher post-flu vaccine antibody responses than PWH without OUD. The plasma profile in PWH+OUD was dominant in co-stimulatory TNF SF molecules, including 4-1BB, OX-40, CD40, CD30, and 4-1BBL and positively correlated with Flu Ab titers. In PWH without OUD, Ig SF molecules, including PDL-2, CTLA-4, and Perforin were dominant, with PDL-2 showing a negative correlation with Flu Ab titers. The role of opioid receptors and SF signaling pathways may reveal novel therapeutic strategies for immune-deficient states. View this paper
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Articles (116)

  • Article
  • Open Access
7 Citations
3,113 Views
28 Pages

Healthcare Providers’ and Pregnant People’s Preferences for a Preventive to Protect Infants from Serious Illness Due to Respiratory Syncytial Virus

  • Kathleen M. Beusterien,
  • Amy W. Law,
  • Martine C. Maculaitis,
  • Oliver Will,
  • Lewis Kopenhafer,
  • Patrick Olsen,
  • Brett Hauber,
  • Jeffrey T. Vietri,
  • Joseph C. Cappelleri and
  • Joshua R. Coulter
  • + 1 author

We assessed the impact of respiratory syncytial virus (RSV) preventive characteristics on the intentions of pregnant people and healthcare providers (HCPs) to protect infants with a maternal vaccine or monoclonal antibodies (mAbs). Pregnant people an...

  • Article
  • Open Access
7,263 Views
25 Pages

The Biodistribution of the Spike Protein after Ad26.COV2.S Vaccination Is Unlikely to Play a Role in Vaccine-Induced Immune Thrombotic Thrombocytopenia

  • Sonia Marquez-Martinez,
  • Selina Khan,
  • Joan van der Lubbe,
  • Laura Solforosi,
  • Lea M. M. Costes,
  • Ying Choi,
  • Satish Boedhoe,
  • Mieke Verslegers,
  • Marjolein van Heerden and
  • Wendy Roosen
  • + 8 authors

Ad26.COV2.S vaccination can lead to vaccine-induced immune thrombotic thrombocytopenia (VITT), a rare but severe adverse effect, characterized by thrombocytopenia and thrombosis. The mechanism of VITT induction is unclear and likely multifactorial, p...

  • Article
  • Open Access
2,044 Views
14 Pages

Accuracy of Anti-SARS-CoV-2 Antibody in Comparison with Surrogate Viral Neutralization Test in Persons Living with HIV, Systemic Lupus Erythematosus, and Chronic Kidney Disease

  • Marita Restie Tiara,
  • Chrisan Bimo Prayuda,
  • Tara Titian Maulidya,
  • Hofiya Djauhari,
  • Dadang Suhendar,
  • Rudi Wisaksana,
  • Laniyati Hamijoyo,
  • Rudi Supriyadi,
  • Agnes Rengga Indrati and
  • Bachti Alisjahbana

The presence of the anti-SARS-CoV-2-RBD antibody (anti-RBD) prevents severe COVID-19. We aimed to determine the accuracy of a point-of-care anti-RBD testing implemented in persons living with HIV (PLWH), systemic lupus erythematosus (SLE), and chroni...

  • Review
  • Open Access
7 Citations
4,114 Views
36 Pages

Porcine epidemic diarrhea virus (PEDV) is the etiology of porcine epidemic diarrhea (PED), a highly contagious digestive disease in pigs and especially in neonatal piglets, in which a mortality rate of up to 100% will be induced. Immunizing pregnant...

  • Brief Report
  • Open Access
2 Citations
2,707 Views
8 Pages

Analysis of Acute Phase Response Using Acute Phase Proteins Following Simultaneous Vaccination of Lumpy Skin Disease and Foot-and-Mouth Disease

  • Jiyeon Kim,
  • Danil Kim,
  • Hyoeun Noh,
  • Leegon Hong,
  • Eunwoo Chun,
  • Eunkyung Kim,
  • Younghye Ro and
  • Woojae Choi

Since 2011, South Korea has implemented biannual vaccinations against foot-and-mouth disease (FMD) and recently, lumpy skin disease (LSD), to mitigate the spread of transboundary animal diseases. However, due to past adverse reactions, potentially li...

  • Opinion
  • Open Access
2 Citations
3,492 Views
10 Pages

The author believes that the principles of statistical methods for vaccine safety can be divided into three categories: comparison of adverse event incidence rates between vaccinated and unvaccinated groups, analysis of incidentality in the vaccinate...

  • Review
  • Open Access
10 Citations
10,319 Views
24 Pages

SARS-CoV-2 Neutralization Assays Used in Clinical Trials: A Narrative Review

  • Yeqing Sun,
  • Weijin Huang,
  • Hongyu Xiang and
  • Jianhui Nie

Since the emergence of COVID-19, extensive research efforts have been undertaken to accelerate the development of multiple types of vaccines to combat the pandemic. These include inactivated, recombinant subunit, viral vector, and nucleic acid vaccin...

  • Article
  • Open Access
2 Citations
2,296 Views
15 Pages

COVID-19 vaccination is vital in reducing illness, hospitalization, and mortality in the face of this global pandemic. However, COVID-19 vaccination rates worldwide remain below WHO public health targets, and persistent structural inequities reduce v...

  • Article
  • Open Access
1 Citations
1,778 Views
17 Pages

A Low Number of Baselines γδ T Cells Increases the Risk of SARS-CoV-2 Post-Vaccination Infection

  • Juan Carlos Andreu-Ballester,
  • Lorena Galindo-Regal,
  • Carmen Cuéllar,
  • Francisca López-Chuliá,
  • Carlos García-Ballesteros,
  • Leonor Fernández-Murga,
  • Antonio Llombart-Cussac and
  • María Victoria Domínguez-Márquez

Background: The COVID-19 pandemic is the biggest global health problem in the last hundred years. The efficacy of the vaccine to protect against severe disease is estimated to be 70–95% according to the studies carried out, although there are a...

  • Article
  • Open Access
2 Citations
3,166 Views
11 Pages

Vaccine Acceptance in Patients with Inflammatory Bowel Disease: Lessons Learned from the COVID-19 Pandemic

  • Giada Mastrangeli,
  • Filippo Vernia,
  • Stefano Necozione,
  • Mario Muselli,
  • Sara Frassino,
  • Nicola Cesaro,
  • Giovanni Latella and
  • Leila Fabiani

Background: Immunomodulating therapies, which are commonly used in patients with Crohn’s disease (CD) and ulcerative colitis (UC), have been linked to an increased risk of contracting opportunistic infectious diseases, the majority of which are...

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Vaccines - ISSN 2076-393X