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Antioxidants, Volume 12, Issue 11

November 2023 - 118 articles

Cover Story: Ascorbate is a cofactor for a superfamily of enzymes that govern numerous pathways in cancer progression. The kinetics of ascorbate uptake and retention in cancer cells are unclear. Here, we show that the accumulation of ascorbate by breast cancer cells occurred within hours of supplementation, and was then depleted after 24 h if not re-supplemented. Ascorbate transporter SVCT2 was localised mainly to subcellular compartments, indicating the importance of ascorbate trafficking from the cytosol to the organelles for its cofactor function. We demonstrate that careful management of ascorbate supplementation in vitro allows for the approximation of in vivo conditions. View this paper
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Articles (118)

  • Article
  • Open Access
6 Citations
2,085 Views
12 Pages

20 November 2023

Natural flavonoids are renowned for their exceptional antioxidant properties, but their limited water solubility hampers their bioavailability. One approach to enhancing their water solubility and antioxidant activity involves the use of cyclodextrin...

  • Review
  • Open Access
11 Citations
5,786 Views
18 Pages

Melatonin in Neurodevelopmental Disorders: A Critical Literature Review

  • Cyrille Feybesse,
  • Sylvie Chokron and
  • Sylvie Tordjman

20 November 2023

The article presents a review of the relationships between melatonin and neurodevelopmental disorders. First, the antioxidant properties of melatonin and its physiological effects are considered to understand better the role of melatonin in typical a...

  • Review
  • Open Access
19 Citations
5,019 Views
27 Pages

18 November 2023

Acute respiratory distress syndrome (ARDS) is a life-threatening pulmonary condition characterized by the sudden onset of respiratory failure, pulmonary edema, dysfunction of endothelial and epithelial barriers, and the activation of inflammatory cas...

  • Review
  • Open Access
66 Citations
38,509 Views
26 Pages

18 November 2023

Ginger is an herbaceous and flowering plant renowned for its rhizome, which is widely employed as both a spice and an herb. Since ancient times, ginger has been consumed in folk medicine and traditional cuisines for its favorable health effects. Diff...

  • Review
  • Open Access
68 Citations
6,268 Views
53 Pages

Antioxidants of Non-Enzymatic Nature: Their Function in Higher Plant Cells and the Ways of Boosting Their Biosynthesis

  • Natalia N. Rudenko,
  • Daria V. Vetoshkina,
  • Tatiana V. Marenkova and
  • Maria M. Borisova-Mubarakshina

17 November 2023

Plants are exposed to a variety of abiotic and biotic stresses leading to increased formation of reactive oxygen species (ROS) in plant cells. ROS are capable of oxidizing proteins, pigments, lipids, nucleic acids, and other cell molecules, disruptin...

  • Article
  • Open Access
8 Citations
2,694 Views
20 Pages

Hepatoprotective Mechanisms Induced by Spinach Methanolic Extract in Rats with Hyperglycemia—An Immunohistochemical Analysis

  • Javier Flores-Estrada,
  • Agustina Cano-Martínez,
  • Álvaro Vargas-González,
  • Vicente Castrejón-Téllez,
  • Jorge Cornejo-Garrido,
  • Martín Martínez-Rosas,
  • Verónica Guarner-Lans and
  • María Esther Rubio-Ruíz

17 November 2023

Spinach methanolic extract (SME) has a hepatoprotective effect due to its polyphenolic antioxidants; however, its action in parenchymal (PQ) and non-parenchymal (nPQ) cells remains unknown. This study investigates the hepatoprotective effect of SME o...

  • Review
  • Open Access
19 Citations
5,603 Views
52 Pages

Phytochemicals Target Multiple Metabolic Pathways in Cancer

  • Oleg Shuvalov,
  • Yulia Kirdeeva,
  • Alexandra Daks,
  • Olga Fedorova,
  • Sergey Parfenyev,
  • Hans-Uwe Simon and
  • Nickolai A. Barlev

17 November 2023

Cancer metabolic reprogramming is a complex process that provides malignant cells with selective advantages to grow and propagate in the hostile environment created by the immune surveillance of the human organism. This process underpins cancer proli...

  • Review
  • Open Access
22 Citations
3,005 Views
12 Pages

17 November 2023

The imbalance of redox homeostasis contributes to neurodegeneration, including that related to the visual system. Mitochondria, essential in providing energy and responsible for several cell functions, are a significant source of reactive oxygen and/...

  • Article
  • Open Access
15 Citations
2,656 Views
20 Pages

Antioxidant Properties and Geroprotective Potential of Wheat Bran Extracts with Increased Content of Anthocyanins

  • Daria V. Mikhailova,
  • Oksana G. Shevchenko,
  • Denis A. Golubev,
  • Elena Y. Platonova,
  • Nadezhda V. Zemskaya,
  • Olesya Yu. Shoeva,
  • Elena I. Gordeeva,
  • Sergey A. Patov,
  • Mikhail V. Shaposhnikov and
  • Elena K. Khlestkina
  • + 1 author

17 November 2023

In recent years, there has been a focus on breeding wheat with high anthocyanin levels in order to improve food quality and human health. The objective of this study was to examine the antioxidant and geroprotective properties of wheat bran extracts...

  • Article
  • Open Access
11 Citations
2,515 Views
15 Pages

HDL-Related Parameters and COVID-19 Mortality: The Importance of HDL Function

  • Julia T. Stadler,
  • Hansjörg Habisch,
  • Florian Prüller,
  • Harald Mangge,
  • Thomas Bärnthaler,
  • Julia Kargl,
  • Anja Pammer,
  • Michael Holzer,
  • Sabine Meissl and
  • Alankrita Rani
  • + 2 authors

16 November 2023

COVID-19, caused by the SARS-CoV-2 coronavirus, emerged as a global pandemic in late 2019, resulting in significant global public health challenges. The emerging evidence suggests that diminished high-density lipoprotein (HDL) cholesterol levels are...

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Antioxidants - ISSN 2076-3921